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Chemical Compound Review

hydroxyazanium     hydroxyazanium

Synonyms: AG-L-18721, AC1L1ACQ, CTK7F3165, hydroxyammonium
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Disease relevance of hydroxyazanium


High impact information on hydroxyazanium

  • The exposure of the stomach to 15-60 mmol/L ammonium hydroxide induced both a reduction in transmucosal potential difference and microscopic damage to the gastric mucosa in normotensive rats [1].
  • Whereas ammonium hydroxide or hypotonic lysis resulted in relatively high levels of matrix-associated TF, virtually no TF was found on the matrix after mild enzymatic detachment of stimulated ECs [4].
  • Extracellular matrix derived from TNF-treated endothelium, prepared after removing the cells by hypotonic lysis or ammonium hydroxide (0.1 N), also had similarly enhanced TF activity [5].
  • PI10-containing complexes are dissociated with conditions known to separate classical protease-serpin complexes (i.e., 1.5 m ammonium hydroxide in the presence of SDS) [6].
  • After removal of the cells in culture adherent to glass with 25 mM ammonium hydroxide, indirect immunofluorescence demonstrated an exuberant residual extracellular residue enriched with fibronectin, laminin, collagen type IV, and procollagen type III [7].

Biological context of hydroxyazanium


Anatomical context of hydroxyazanium


Associations of hydroxyazanium with other chemical compounds


Gene context of hydroxyazanium

  • The total activity of LPL, measured in ammonium hydroxide extracts of acetone ether tissue powders, was in the low normal range in the hypothyroid patients (0.68 +/- 0.42), but not significantly different from normal (1.10 +/- 0.58) and did not increase significantly (92 +/- 105%), with treatment [23].
  • METHODS: Confluent first-to third-passage human RPE were harvested from tissue culture and plated onto RPE-derived extracellular matrix or human Bruch's membrane exoplants denuded of cells by treatment with 0.02 N ammonium hydroxide [24].
  • We conclude that vagal afferents transmit physiological stimuli (gastrin) and pathological events (backdiffusion of luminal HCl or NH(4)OH) from the stomach to the brain stem [22].
  • For concentrated ammonium hydroxide, an on-line electrochemical neutralizer (SP10 AutoNeutralization module) was used to neutralize the base prior to the IC analysis [25].
  • 1. Ammonium hydroxide treatment of [des-Asn1]-EGF (beta-EGF) did not produce conversion to EGF-I [26].

Analytical, diagnostic and therapeutic context of hydroxyazanium


  1. Gastric ammonia has a potent ulcerogenic action on the rat stomach. Murakami, M., Saita, H., Teramura, S., Dekigai, H., Asagoe, K., Kusaka, S., Kita, T. Gastroenterology (1993) [Pubmed]
  2. Comparison of topical antibiotic ointments, a wound protectant, and antiseptics for the treatment of human blister wounds contaminated with Staphylococcus aureus. Leyden, J.J., Bartelt, N.M. The Journal of family practice. (1987) [Pubmed]
  3. Chemical compositions of cell walls and polysaccharide fractions of spirochetes. Yanagihara, Y., Kamisango, K., Yasuda, S., Kobayashi, S., Mifuchi, I., Azuma, I., Yamamura, Y., Johnson, R.C. Microbiol. Immunol. (1984) [Pubmed]
  4. Tumor necrosis factor alpha-induced endothelial tissue factor is located on the cell surface rather than in the subendothelial matrix. Mulder, A.B., Hegge-Paping, K.S., Magielse, C.P., Blom, N.R., Smit, J.W., van der Meer, J., Hallie, M.R., Bom, V.J. Blood (1994) [Pubmed]
  5. Tumor necrosis factor-induced endothelial tissue factor is associated with subendothelial matrix vesicles but is not expressed on the apical surface. Ryan, J., Brett, J., Tijburg, P., Bach, R.R., Kisiel, W., Stern, D. Blood (1992) [Pubmed]
  6. Protease inhibitor 10 inhibits tumor necrosis factor alpha -induced cell death. Evidence for the formation of intracellular high M(r) protease inhibitor 10-containing complexes. Schleef, R.R., Chuang, T.L. J. Biol. Chem. (2000) [Pubmed]
  7. An ultrastructural and immunocytochemical analysis of leptomeningeal and meningioma cultures. Rutka, J.T., Giblin, J., Dougherty, D.V., McCulloch, J.R., DeArmond, S.J., Rosenblum, M.L. J. Neuropathol. Exp. Neurol. (1986) [Pubmed]
  8. Ammonium hydroxide hydrolysis: a valuable support in the MALDI-TOF mass spectrometry analysis of Lipid A fatty acid distribution. Silipo, A., Lanzetta, R., Amoresano, A., Parrilli, M., Molinaro, A. J. Lipid Res. (2002) [Pubmed]
  9. Determination of antrafenine and its main acid metabolite, 2-(17-(trifluoromethyl)-4-quinolinyl]amino)-benzoic acid, in biological fluids using high-performance liquid chromatography with large volume automatic injection and gas-liquid chromatography with derivative formation. Guinebault, P.R., Broquaire, M., Sanjuan, M., Rovei, V., Braithwaite, R.A. J. Chromatogr. (1981) [Pubmed]
  10. Differential sensitivity of chromium-mediated DNA interstrand crosslinks and DNA-protein crosslinks to disruption by alkali and EDTA. Singh, J., Bridgewater, L.C., Patierno, S.R. Toxicol. Sci. (1998) [Pubmed]
  11. Tear fluid content of electrochemically active components including water soluble antioxidants. Gogia, R., Richer, S.P., Rose, R.C. Curr. Eye Res. (1998) [Pubmed]
  12. Kinetics of phthalate reactions with ammonium hydroxide in aqueous matrix. Patnaik, P., Yang, M., Powers, E. Water Res. (2001) [Pubmed]
  13. The translaminal fibrils of the human amnion basement membrane. Campbell, S., Allen, T.D., Moser, B.B., Aplin, J.D. J. Cell. Sci. (1989) [Pubmed]
  14. Improved negative staining of microfilament arrangements in detergent-extracted Physarum amoeboflagellates. Pagh, K.I., Vergara, J.A., Adelman, M.R. Exp. Cell Res. (1985) [Pubmed]
  15. Fate of human retinal pigment epithelial cells seeded onto layers of human Bruch's membrane. Tezel, T.H., Kaplan, H.J., Del Priore, L.V. Invest. Ophthalmol. Vis. Sci. (1999) [Pubmed]
  16. Concentration of ammonium hydroxide is critical in chromatographic solvents for amniotic fluid phospholipids. Glick, J.H., Crocker, C.L. Clin. Chem. (1982) [Pubmed]
  17. Efficacy of common laboratory disinfectants on the infectivity of Cryptosporidium parvum oocysts in cell culture. Weir, S.C., Pokorny, N.J., Carreno, R.A., Trevors, J.T., Lee, H. Appl. Environ. Microbiol. (2002) [Pubmed]
  18. Atmospheric pressure photoionization mass spectrometry. Ionization mechanism and the effect of solvent on the ionization of naphthalenes. Kauppila, T.J., Kuuranne, T., Meurer, E.C., Eberlin, M.N., Kotiaho, T., Kostiainen, R. Anal. Chem. (2002) [Pubmed]
  19. LC/MS/MS method for quantitative determination of long-chain fatty acyl-CoAs. Magnes, C., Sinner, F.M., Regittnig, W., Pieber, T.R. Anal. Chem. (2005) [Pubmed]
  20. Multiply charged negative ions by electrospray ionization of polypeptides and proteins. Loo, J.A., Loo, R.R., Light, K.J., Edmonds, C.G., Smith, R.D. Anal. Chem. (1992) [Pubmed]
  21. The stability of uric acid in ammonium hydroxide. Ellerbe, P., Cohen, A., Welch, M.J., White, E. Clin. Chem. (1988) [Pubmed]
  22. Stomach-brain communication by vagal afferents in response to luminal acid backdiffusion, gastrin, and gastric acid secretion. Danzer, M., Jocic, M., Samberger, C., Painsipp, E., Bock, E., Pabst, M.A., Crailsheim, K., Schicho, R., Lippe, I.T., Holzer, P. Am. J. Physiol. Gastrointest. Liver Physiol. (2004) [Pubmed]
  23. Reversal of decreased human adipose tissue lipoprotein lipase and hypertriglyceridemia after treatment of hypothyroidism. Pykälistö, O., Goldberg, A.P., Brunzell, J.D. J. Clin. Endocrinol. Metab. (1976) [Pubmed]
  24. Reattachment of cultured human retinal pigment epithelium to extracellular matrix and human Bruch's membrane. Ho, T.C., Del Priore, L.V. Invest. Ophthalmol. Vis. Sci. (1997) [Pubmed]
  25. Ion chromatographic analysis of anions in ammonium hydroxide, hydrofluoric acid, and slurries, used in semiconductor processing. Wang, K., Lei, Y., Eitel, M., Tan, S. Journal of chromatography. A. (2002) [Pubmed]
  26. Evidence for isoaspartyl (deamidated) forms of mouse epidermal growth factor. DiAugustine, R.P., Gibson, B.W., Aberth, W., Kelly, M., Ferrua, C.M., Tomooka, Y., Brown, C.F., Walker, M. Anal. Biochem. (1987) [Pubmed]
  27. Revision of the structure for an endo-beta-N-acetylglucosaminidase H substrate using a novel modification of the Smith degradation. Maley, F., Trimble, R.B. J. Biol. Chem. (1981) [Pubmed]
  28. Selective activation of mitomycin A by thiols to form DNA cross-links and monoadducts: biochemical basis for the modulation of mitomycin cytotoxicity by the quinone redox potential. Paz, M.M., Das, A., Palom, Y., He, Q.Y., Tomasz, M. J. Med. Chem. (2001) [Pubmed]
  29. High-performance liquid chromatography separation and light-scattering detection of phospholipids from cooked beef. Caboni, M.F., Menotta, S., Lercker, G. Journal of chromatography. A. (1994) [Pubmed]
  30. Effect of ammonium hydroxide concentration on the recoveries of amino acids during preparation for gas-liquid chromatography. Boila, R.J., Milligan, L.P. J. Chromatogr. (1980) [Pubmed]
  31. Determination of water-soluble acid distribution in poly(lactide-co-glycolide). Ding, A.G., Schwendeman, S.P. Journal of pharmaceutical sciences. (2004) [Pubmed]
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