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Chemical Compound Review

Tabtoxin     (2S,3R)-2-[[(2S)-2-amino-4- [(3S)-3-hydroxy...

Synonyms: AC1Q5QOD, AR-1K4320, AC1L32SX, 40957-90-2
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Disease relevance of Tabtoxin


High impact information on Tabtoxin


Biological context of Tabtoxin

  • As part of our investigation of the self-protection mechanism(s) used by these pathovars, we have determined that GS becomes adenylylated after toxin production is initiated and that the serine released from the zinc-activated hydrolysis of tabtoxin is a factor in the initiation of this adenylylation [7].
  • The biosynthetic gene cluster for the beta-lactam antibiotic tabtoxin in Pseudomonas syringae [8].
  • Tabtoxin resistance protein (TTR) is an enzyme that catalyzes the acetylation of tabtoxin rendering tabtoxin-producing pathogens tolerant to their own phytotoxins [9].

Analytical, diagnostic and therapeutic context of Tabtoxin


  1. Pseudomonas syringae phytotoxins: mode of action, regulation, and biosynthesis by peptide and polyketide synthetases. Bender, C.L., Alarcón-Chaidez, F., Gross, D.C. Microbiol. Mol. Biol. Rev. (1999) [Pubmed]
  2. Regulation of tabtoxin production by the lemA gene in Pseudomonas syringae. Barta, T.M., Kinscherf, T.G., Willis, D.K. J. Bacteriol. (1992) [Pubmed]
  3. Effects of nutritional factors on production of tabtoxin, a phytotoxin, by Pseudomonas syringae pv. tabaci. Dehbi, F., Harzallah, D., Larous, L. Mededelingen (Rijksuniversiteit te Gent. Fakulteit van de Landbouwkundige en Toegepaste Biologische Wetenschappen) (2001) [Pubmed]
  4. DNA sequence and transcriptional analysis of the tblA gene required for tabtoxin biosynthesis by Pseudomonas syringae. Barta, T.M., Kinscherf, T.G., Uchytil, T.F., Willis, D.K. Appl. Environ. Microbiol. (1993) [Pubmed]
  5. Cloning and expression of the tabtoxin biosynthetic region from Pseudomonas syringae. Kinscherf, T.G., Coleman, R.H., Barta, T.M., Willis, D.K. J. Bacteriol. (1991) [Pubmed]
  6. Cloning and characterization of Saccharomyces cerevisiae genes that confer L-methionine sulfoximine and tabtoxin resistance. Marek, E.T., Dickson, R.C. J. Bacteriol. (1987) [Pubmed]
  7. Role of glutamine synthetase adenylylation in the self-protection of Pseudomonas syringae subsp. "tabaci" from its toxin, tabtoxinine-beta-lactam. Knight, T.J., Durbin, R.D., Langston-Unkefer, P.J. J. Bacteriol. (1986) [Pubmed]
  8. The biosynthetic gene cluster for the beta-lactam antibiotic tabtoxin in Pseudomonas syringae. Kinscherf, T.G., Willis, D.K. J. Antibiot. (2005) [Pubmed]
  9. Site-directed mutagenesis and preliminary x-ray crystallographic studies of the tabtoxin resistance protein. Ding, Y., Li, S., Li, X., Sun, F., Liu, J., Zhao, N., Rao, Z. Protein Pept. Lett. (2003) [Pubmed]
  10. Detection of tabtoxin-producing strains of Pseudomonas syringae by PCR. Lydon, J., Patterson, C.D. Lett. Appl. Microbiol. (2001) [Pubmed]
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