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Chemical Compound Review

GSSeSG     (2S)-2-amino-4-[[(1S)-2- [(2S)-2-[[(4S)-4...

Synonyms: GS-Se-SG, CHEBI:26634, KST-1A4092, LS-71933, AR-1A3612, ...
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Disease relevance of Selenodiglutathione


High impact information on Selenodiglutathione


Biological context of Selenodiglutathione


Anatomical context of Selenodiglutathione


Associations of Selenodiglutathione with other chemical compounds


Gene context of Selenodiglutathione


Analytical, diagnostic and therapeutic context of Selenodiglutathione

  • The liquid chromatography - mass spectrometry (LC-MS) data showed that, in the ionic condition of incubation medium, GSH promptly reduced SeO3(2-) (< or = 2 min) in its elemental form Se0, which cannot ascribe to selenodiglutathione a direct role in the effect of GSH [19].


  1. The selenium metabolite selenodiglutathione induces cell death by a mechanism distinct from H2O2 toxicity. Wu, L., Lanfear, J., Harrison, P.R. Carcinogenesis (1995) [Pubmed]
  2. The activity of methylated and non-methylated selenium species in lymphoma cell lines and primary tumours. Last, K., Maharaj, L., Perry, J., Strauss, S., Fitzgibbon, J., Lister, T.A., Joel, S. Ann. Oncol. (2006) [Pubmed]
  3. Inhibition by selenium of DNA and RNA synthesis in normal and malignant human cells in vitro. Abdullaev, F.I., MacVicar, C., Frenkel, G.D. Cancer Lett. (1992) [Pubmed]
  4. Toxic effects of selenodiglutathione on pregnant mice. Yonemoto, J., Hongo, T., Suzuki, T., Naganuma, A., Imura, N. Toxicol. Lett. (1984) [Pubmed]
  5. Characterization of potential selenium-binding proteins in the selenophosphate synthetase system. Ogasawara, Y., Lacourciere, G.M., Ishii, K., Stadtman, T.C. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  6. Selenite and selenate inhibit human lymphocyte growth via different mechanisms. Spyrou, G., Björnstedt, M., Skog, S., Holmgren, A. Cancer Res. (1996) [Pubmed]
  7. Differential effects of selenium on normal and neoplastic canine mammary cells. Fico, M.E., Poirier, K.A., Watrach, A.M., Watrach, M.A., Milner, J.A. Cancer Res. (1986) [Pubmed]
  8. Similarities between the abiotic reduction of selenite with glutathione and the dissimilatory reaction mediated by Rhodospirillum rubrum and Escherichia coli. Kessi, J., Hanselmann, K.W. J. Biol. Chem. (2004) [Pubmed]
  9. The selenium metabolite selenodiglutathione induces p53 and apoptosis: relevance to the chemopreventive effects of selenium? Lanfear, J., Fleming, J., Wu, L., Webster, G., Harrison, P.R. Carcinogenesis (1994) [Pubmed]
  10. Role of glutathione and methylation in the biliary excretion of selenium. The paradoxical effect of sulfobromophthalein. Gyurasics, A., Perjési, P., Gregus, Z. Biochem. Pharmacol. (1998) [Pubmed]
  11. Studies on the inhibition of protein synthesis by selenodiglutathione. Vernie, L.N., Collard, J.G., Eker, A.P., de Wildt, A., Wilders, I.T. Biochem. J. (1979) [Pubmed]
  12. Selenite incubated with NADPH and mammalian thioredoxin reductase yields selenide, which inhibits lipoxygenase and changes the electron spin resonance spectrum of the active site iron. Björnstedt, M., Odlander, B., Kuprin, S., Claesson, H.E., Holmgren, A. Biochemistry (1996) [Pubmed]
  13. Properties of the cadmium and selenium complex formed in rat plasma in vivo and in vitro. Gasiewicz, T.A., Smith, J.C. Chem. Biol. Interact. (1978) [Pubmed]
  14. Elongation factor 2 as the target of the reaction product between sodium selenite and glutathione (GSSeSG) in the inhibiting of amino acid incorporation in vitro. Vernie, L.N., Bont, W.S., Ginjaar, H.B., Emmelot, P. Biochim. Biophys. Acta (1975) [Pubmed]
  15. Metabolism of subtoxic levels of selenium in animals and humans. Whanger, P., Vendeland, S., Park, Y.C., Xia, Y. Ann. Clin. Lab. Sci. (1996) [Pubmed]
  16. AP-1 DNA-binding activity is inhibited by selenite and selenodiglutathione. Spyrou, G., Björnstedt, M., Kumar, S., Holmgren, A. FEBS Lett. (1995) [Pubmed]
  17. Selenodiglutathione is a highly efficient oxidant of reduced thioredoxin and a substrate for mammalian thioredoxin reductase. Björnstedt, M., Kumar, S., Holmgren, A. J. Biol. Chem. (1992) [Pubmed]
  18. Amino acid incorporation in a cell-free system derived from rat liver studied with the aid of selenodiglutathione. Vernie, L.N., Ginjaar, H.B., Wilders, I.T., Bont, W.S. Biochim. Biophys. Acta (1978) [Pubmed]
  19. Transport measurements across Caco-2 monolayers of different organic and inorganic selenium: influence of sulfur compounds. Leblondel, G., Mauras, Y., Cailleux, A., Allain, P. Biological trace element research. (2001) [Pubmed]
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