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Chemical Compound Review

CHEMBL399906     seleninomethane

Synonyms: AG-E-90634, LS-90052, CTK1A6305, AR-1J4068, AR-1J4069, ...
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Disease relevance of Methylselenic acid


High impact information on Methylselenic acid


Chemical compound and disease context of Methylselenic acid


Biological context of Methylselenic acid


Associations of Methylselenic acid with other chemical compounds


Gene context of Methylselenic acid


Analytical, diagnostic and therapeutic context of Methylselenic acid


  1. Diverse effects of methylseleninic acid on the transcriptional program of human prostate cancer cells. Zhao, H., Whitfield, M.L., Xu, T., Botstein, D., Brooks, J.D. Mol. Biol. Cell (2004) [Pubmed]
  2. Intracellular glutathione is a cofactor in methylseleninic acid-induced apoptotic cell death of human hepatoma HEPG(2) cells. Shen, H.M., Ding, W.X., Ong, C.N. Free Radic. Biol. Med. (2002) [Pubmed]
  3. Cell cycle arrest biomarkers in human lung cancer cells after treatment with selenium in culture. Swede, H., Dong, Y., Reid, M., Marshall, J., Ip, C. Cancer Epidemiol. Biomarkers Prev. (2003) [Pubmed]
  4. Synergy between selenium and vitamin E in apoptosis induction is associated with activation of distinctive initiator caspases in human prostate cancer cells. Zu, K., Ip, C. Cancer Res. (2003) [Pubmed]
  5. Mechanisms of cell cycle arrest by methylseleninic acid. Zhu, Z., Jiang, W., Ganther, H.E., Thompson, H.J. Cancer Res. (2002) [Pubmed]
  6. Antimitogenic and proapoptotic activities of methylseleninic acid in vascular endothelial cells and associated effects on PI3K-AKT, ERK, JNK and p38 MAPK signaling. Wang, Z., Jiang, C., Ganther, H., Lü, J. Cancer Res. (2001) [Pubmed]
  7. Caspases as key executors of methyl selenium-induced apoptosis (anoikis) of DU-145 prostate cancer cells. Jiang, C., Wang, Z., Ganther, H., Lu, J. Cancer Res. (2001) [Pubmed]
  8. Augmented suppression of androgen receptor signaling by a combination of alpha-tocopheryl succinate and methylseleninic acid. Zhang, H., Wu, Y., Malewicz, B., Lu, J., Li, S., Marshall, J., Ip, C., Dong, Y. Cancer (2006) [Pubmed]
  9. Inhibition of androgen receptor signaling by selenite and methylseleninic acid in prostate cancer cells: two distinct mechanisms of action. Husbeck, B., Bhattacharyya, R.S., Feldman, D., Knox, S.J. Mol. Cancer Ther. (2006) [Pubmed]
  10. Methyl selenium metabolites decrease prostate-specific antigen expression by inducing protein degradation and suppressing androgen-stimulated transcription. Cho, S.D., Jiang, C., Malewicz, B., Dong, Y., Young, C.Y., Kang, K.S., Lee, Y.S., Ip, C., Lü, J. Mol. Cancer Ther. (2004) [Pubmed]
  11. Distribution and reuse of (76)Se-selenosugar in selenium-deficient rats. Suzuki, K.T., Somekawa, L., Suzuki, N. Toxicol. Appl. Pharmacol. (2006) [Pubmed]
  12. Evidence of a field effect associated with mammary cancer chemoprevention by methylseleninic acid. Dong, Y., Ip, C., Ganther, H. Anticancer Res. (2002) [Pubmed]
  13. In vitro and in vivo studies of methylseleninic acid: evidence that a monomethylated selenium metabolite is critical for cancer chemoprevention. Ip, C., Thompson, H.J., Zhu, Z., Ganther, H.E. Cancer Res. (2000) [Pubmed]
  14. Selenomethionine induced transcriptional programs in human prostate cancer cells. Zhao, H., Brooks, J.D. J. Urol. (2007) [Pubmed]
  15. Allium chemistry: synthesis, natural occurrence, biological activity, and chemistry of Se-alk(en)ylselenocysteines and their gamma-glutamyl derivatives and oxidation products. Block, E., Birringer, M., Jiang, W., Nakahodo, T., Thompson, H.J., Toscano, P.J., Uzar, H., Zhang, X., Zhu, Z. J. Agric. Food Chem. (2001) [Pubmed]
  16. Monomethyl selenium--specific inhibition of MMP-2 and VEGF expression: implications for angiogenic switch regulation. Jiang, C., Ganther, H., Lu, J. Mol. Carcinog. (2000) [Pubmed]
  17. Monomethylated selenium inhibits growth of LNCaP human prostate cancer xenograft accompanied by a decrease in the expression of androgen receptor and prostate-specific antigen (PSA). Lee, S.O., Yeon Chun, J., Nadiminty, N., Trump, D.L., Ip, C., Dong, Y., Gao, A.C. Prostate (2006) [Pubmed]
  18. Androgen receptor signaling intensity is a key factor in determining the sensitivity of prostate cancer cells to selenium inhibition of growth and cancer-specific biomarkers. Dong, Y., Zhang, H., Gao, A.C., Marshall, J.R., Ip, C. Mol. Cancer Ther. (2005) [Pubmed]
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