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Chemical Compound Review

Lealgin     ethyl1-(3-hydroxy-3-phenyl- propyl)-4...

Synonyms: Fenoperidina, Fenoperidine, Phenoperidin, PHENOPERIDINE, Phenoperidinum, ...
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Disease relevance of R 1406


High impact information on R 1406


Chemical compound and disease context of R 1406


Biological context of R 1406

  • Therefore, the antagonism of phenoperidine action by morphine appeared not to occur at the opiate receptor site; the mechanism of the pika's natural tolerance to morphine may reside in molecular events that normally preceed (metabolism?) or follow (enzyme activation?) the interaction between the drug and its specific recognition sites [11].

Associations of R 1406 with other chemical compounds

  • The effects of bolus doses of phenoperidine 1-2 mg i.v. either alone, or combined with pancuronium 2-4 mg, were investigated in seven patients in traumatic coma [6].
  • Mean blood loss in patients who received phenoperidine was 1065 +/- 316 ml and in patients who received extradural analgesia with 0.5% bupivacaine with adrenaline 1:200 000 it was 650 +/- 277 ml (p less than 0.001) [12].
  • Although many anaesthetic techniques including regional analgesia may be used successfully in these patients caution with most drugs, especially pethidine, phenoperidine, suxamethonium and all non-depolarising neuromuscular relaxants is recommended [13].

Gene context of R 1406

  • These findings suggest that the bolus administration of phenoperidine and probably other opiates should be avoided in traumatic coma [6].
  • A survey of sedation techniques for ventilated patients was performed by visiting 34 Intensive Care Units in Great Britain and Northern Ireland. The opiates in frequent used were phenoperidine (21 units - 62% of units), papaveretum (11 - 32%) and morphine (9-26%) [14].

Analytical, diagnostic and therapeutic context of R 1406


  1. Elimination of phenoperidine in liver disease. Isherwood, C.N., Calvey, T.N., Williams, N.E., Chan, K., Murray, G.R. British journal of anaesthesia. (1984) [Pubmed]
  2. Intracranial pressure after phenoperidine. Grummitt, R.M., Goat, V.A. Anaesthesia. (1984) [Pubmed]
  3. Influence of anaesthetic technique on postoperative pain. A comparison of anaesthetic supplementation with halothane and with phenoperidine. Henderson, J.J., Parbrook, G.D. British journal of anaesthesia. (1976) [Pubmed]
  4. The antagonist effect of naloxone hydrochloride after neuroleptanaesthesia during neurosurgery. Arnér, S., Gordon, E. Acta anaesthesiologica Scandinavica. (1976) [Pubmed]
  5. A comparison of diazepam and phenoperidine in premedication for upper gastrointestinal endoscopy: a randomized double blind controlled study. Werner, D., Ratnaike, R.N., Lawson, M.J., Barrie, J., Streeter, J., Read, T., Grant, A.K. Eur. J. Clin. Pharmacol. (1982) [Pubmed]
  6. Influence of bolus doses of phenoperidine on intracranial pressure and systemic arterial pressure in traumatic coma. Bingham, R.M., Hinds, C.J. British journal of anaesthesia. (1987) [Pubmed]
  7. Pharmacokinetics of phenoperidine. Calvey, T.N., Williams, N.E. British journal of anaesthesia. (1986) [Pubmed]
  8. Pharmacokinetics of phenoperidine in patients undergoing cardiopulmonary bypass. Fischler, M., Levron, J.C., Trang, H., Brodaty, D., Dubois, C., Guilmet, D., Vourc'h, G. British journal of anaesthesia. (1985) [Pubmed]
  9. Effect of antacids on the plasma concentration of phenoperidine. Calvey, T.N., Milne, L.A., Williams, N.E., Chan, K., Murray, G.R. British journal of anaesthesia. (1983) [Pubmed]
  10. Hypotensive effect of propranolol and phenoperidine in tetanus. Woods, K.L. British medical journal. (1978) [Pubmed]
  11. The natural tolerance of the afghan pika (Ochotona rufescens) to morphine. Puget, A., Cros, J., Meunier, J.C. Eur. J. Pharmacol. (1979) [Pubmed]
  12. Blood loss in total hip replacement: extradural v. phenoperidine analgesia. Chin, S.P., Abou-Madi, M.N., Eurin, B., Witvoët, J., Montagne, J. British journal of anaesthesia. (1982) [Pubmed]
  13. Anaesthesia for the patient with impaired renal function. Maddern, P.J. Anaesthesia and intensive care. (1983) [Pubmed]
  14. The techniques used to sedate ventilated patients. A survey of methods used in 34 ICUs in Great Britain. Merriman, H.M. Intensive care medicine. (1981) [Pubmed]
  15. Serum morphine levels. A comparison between continuous subcutaneous infusion and continuous intravenous infusion in postoperative patients. Waldmann, C.S., Eason, J.R., Rambohul, E., Hanson, G.C. Anaesthesia. (1984) [Pubmed]
  16. Double-blind comparison of the efficacy of extradural diamorphine, extradural phenoperidine and i.m. diamorphine following caesarean section. Macrae, D.J., Munishankrappa, S., Burrow, L.M., Milne, M.K., Grant, I.S. British journal of anaesthesia. (1987) [Pubmed]
  17. Early extubation after coronary artery surgery in efficiently rewarmed patients: a postoperative comparison of opioid anesthesia versus inhalational anesthesia and thoracic epidural analgesia. Joachimsson, P.O., Nyström, S.O., Tydén, H. Journal of cardiothoracic anesthesia. (1989) [Pubmed]
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