Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

AC1L1XPX acetyloxymethylimino-methyl- oxido-azanium

Synonyms: acetyloxymethylimino-methyl-oxidoazanium

Borenfreund, E. et al., Imray, C.H. et al., Pollard, M. et al., Kawaura, A. et al., Reddy, B.S. et al., et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of METHYLAZOXYMETHANOL ACETATE

Four weeks after the start of the experimental diets, the animals were given a weekly SC injection of MAM acetate, 25 mg/kg body weight, for a total of 5 times [1].
Induction of cholangiocarcinoma in the Golden Syrian hamster using methylazoxymethyl acetate [2].
Also, the aglycone of cycasin, MAM acetate, induced a variety of tumors, but primarily hepatocellular and renal cell carcinomas [3].
Carcinomas and adenomas of the perianal sebaceous gland were induced in 23 of 24 male (96%) and 16 of 30 female (53%) mice and keratoacanthoma developed in one of 24 male mice within 30 weeks after treatment with MAM acetate [4].

High impact information on METHYLAZOXYMETHANOL ACETATE

Intraocular neoplasms developed in the Japanese medaka, a small fish species, following a single brief exposure to methylazoxymethanol acetate [(MAM-Ac) CAS: 592-62-1] [5].
The influence of diet restriction on induction of intestinal tumors in Sprague-Dawley rats by two unique carcinogenic agents was investigated: methylazoxymethanol acetate [(MAM) CAS: 592-62-1], which requires metabolic activation, and N-methylnitrosourea [(MNU) CAS: 684-93-5], which is a direct-acting carcinogen [6].
The effect of dietary butylated hydroxyanisole (BHA) on methylazoxymethanol acetate [(MAM AC) CAS: 592-62-1; methyl-ONN-azoxy)methanol acetate]-induced intestinal carcinogenesis was studied in female CF1 mice [7].
In the present study, we describe the development of cholangiocarcinoma associated with precursor lesions of bile duct proliferation and dysplasia which occurred following a single i.v. dose of methylazoxymethyl acetate (10, 20 or 40 mg/kg body weight) [2].
An epithelioid cell line derived from fin tissue of bluegill sunfish (designated BG/F) exhibited early indications of cell transformation upon exposure to methylazoxymethanol acetate (MAM acetate) [8].

Biological context of METHYLAZOXYMETHANOL ACETATE

Differential susceptibility of rat and guinea pig colon mucosa DNA to methylation by methylazoxymethyl acetate in vivo [9].

Gene context of METHYLAZOXYMETHANOL ACETATE

CF1 mice were given 10 weekly subcutaneous injections of methylazoxymethyl acetate (MAM) and killed between 16 and 39 weeks after delivery of the first carcinogen treatment [10].

Analytical, diagnostic and therapeutic context of METHYLAZOXYMETHANOL ACETATE

The controls of a fibroblastic cell culture derived from gill tissue of bluegill sunfish showed spontaneous transformation after 6 months of passage, similar to the transformation observed in the experimental MAM acetate treated gill cultures [8].

References

Effect of a marginally lipotrope-deficient diet on methylazoxymethanol acetate carcinogenesis. Kato, K., Mori, H., Takahashi, M., Hirono, I. Nutrition and cancer. (1982) [Pubmed]
Induction of cholangiocarcinoma in the Golden Syrian hamster using methylazoxymethyl acetate. Imray, C.H., Newbold, K.M., Davis, A., Lavelle-Jones, M., Neoptolemos, J.P. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. (1992) [Pubmed]
Tumor incidence in a chemical carcinogenesis study of nonhuman primates. Thorgeirsson, U.P., Dalgard, D.W., Reeves, J., Adamson, R.H. Regulatory toxicology and pharmacology : RTP. (1994) [Pubmed]
Tumors of the anal region induced in mice painted with methylazoxymethanol acetate. Kawaura, A., Kumagai, H., Shibata, M., Izumi, K., Otsuka, H. Gann = Gan. (1981) [Pubmed]
Intraocular neoplasms induced by methylazoxymethanol acetate in Japanese medaka (Oryzias latipes). Hawkins, W.E., Fournie, J.W., Overstreet, R.M., Walker, W.W. J. Natl. Cancer Inst. (1986) [Pubmed]
Tumorigenic effects of direct- and indirect-acting chemical carcinogens in rats on a restricted diet. Pollard, M., Luckert, P.H. J. Natl. Cancer Inst. (1985) [Pubmed]
Dose-response studies of the effect of dietary butylated hydroxyanisole on colon carcinogenesis induced by methylazoxymethanol acetate in female CF1 mice. Reddy, B.S., Maeura, Y. J. Natl. Cancer Inst. (1984) [Pubmed]
Effect of methylazoxymethanol acetate on bluegill sunfish cell cultures in vitro. Borenfreund, E., Babich, H., Martin-Alguacil, N. Ecotoxicol. Environ. Saf. (1989) [Pubmed]
Differential susceptibility of rat and guinea pig colon mucosa DNA to methylation by methylazoxymethyl acetate in vivo. Sohn, O.S., Puz, C., Caswell, N., Fiala, E.S. Cancer Lett. (1985) [Pubmed]
The antitumoral activity of 4'-deoxydoxorubicin compared to doxorubicin and 5-fluorouracil on methylazoxymethanol acetate-induced colon tumors in CF1 mice. Pratesi, G., Deschner, E.E. Cancer (1984) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.