Chemical Compound Review:
Inostamycin (2S)-2-[(2R,3S,4R,5R,6S)-5- ethyl-6-[(2R,3R...
Synonyms:
LS-88495, NSC 638478, AC1L3V66, 129905-10-8
- Inostamycin, an inhibitor of cytidine 5'-diphosphate 1,2-diacyl-sn-glycerol (CDP-DG): inositol transferase, suppresses invasion ability by reducing productions of matrix metalloproteinase-2 and -9 and cell motility in HSC-4 tongue carcinoma cell line. Baba, Y., Tsukuda, M., Mochimatsu, I., Furukawa, S., Kagata, H., Yoji, n.u.l.l., Nagashima, n.u.l.l., Sakai, N., Koshika, S., Imoto, M., Kato, Y. Clin. Exp. Metastasis (2000)
- Cytostatic effect of inostamycin, an inhibitor of cytidine 5'-diphosphate 1,2-diacyl-sn-glycerol (CDP-DG): inositol transferase, on oral squamous cell carcinoma cell lines. Baba, Y., Tsukuda, M., Mochimatsu, I., Furukawa, S., Kagata, H., Nagashima, Y., Koshika, S., Imoto, M., Kato, Y. Cell Biol. Int. (2001)
- Requirement of caspase-3(-like) protease-mediated hydrogen peroxide production for apoptosis induced by various anticancer drugs. Simizu, S., Takada, M., Umezawa, K., Imoto, M. J. Biol. Chem. (1998)
- Transmembrane domain of Bcl-2 is required for inhibition of ceramide synthesis, but not cytochrome c release in the pathway of inostamycin-induced apoptosis. Kawatani, M., Uchi, M., Simizu, S., Osada, H., Imoto, M. Exp. Cell Res. (2003)
- Involvement of protein kinase C-regulated ceramide generation in inostamycin-induced apoptosis. Kawatani, M., Simizu, S., Osada, H., Takada, M., Arber, N., Imoto, M. Exp. Cell Res. (2000)
- Involvement of phosphatidylinositol synthesis in the regulation of S phase induction. Imoto, M., Morii, T., Deguchi, A., Umezawa, K. Exp. Cell Res. (1994)
- Inhibition of cyclin D1 expression and induction of apoptosis by inostamycin in small cell lung carcinoma cells. Imoto, M., Tanabe, K., Simizu, S., Tashiro, E., Takada, M., Umezawa, K. Jpn. J. Cancer Res. (1998)
- Long-lasting accumulation of vinblastine in inostamycin-treated multidrug-resistant KB cells. Kawada, M., Umezawa, K. Jpn. J. Cancer Res. (1991)
- Potentiation of paclitaxel cytotoxicity by inostamycin in human small cell lung carcinoma, Ms-1 cells. Simizu, S., Tanabe, K., Tashiro, E., Takada, M., Umezawa, K., Imoto, M. Jpn. J. Cancer Res. (1998)
- Inostamycin, an inhibitor of P-glycoprotein function, interacts specifically with phosphatidylethanolamine. Kawada, M., Umezawa, K. Jpn. J. Cancer Res. (1995)
- Inostamycin suppresses vascular endothelial growth factor-stimulated growth and migration of human umbilical vein endothelial cells. Baba, Y., Kato, Y., Mochimatsu, I., Nagashima, Y., Kurihara, M., Kawano, T., Taguchi, T., Hata, R., Tsukuda, M. Clin. Exp. Metastasis (2004)
- Inhibition of G1 cyclin expression in normal rat kidney cells by inostamycin, a phosphatidylinositol synthesis inhibitor. Deguchi, A., Imoto, M., Umezawa, K. J. Biochem. (1996)