Disease relevance of methane

• 2'-Fluoro-5-methyl-l-beta-D-arabinosyluracil (FMAU) labeled with carbon-14 was used to image herpes simplex virus type 1-infected regions of rat brain by quantitative autoradiography [1].
• Results of initial experiments with carbon-14-labeled acetate (14C-acetate) indicated that the steady-state extraction fraction of acetate averaged 61.5 +/- 4.0% in control hearts (n = 4), 93.6 +/- 0.9% in hearts rendered ischemic (n = 4), and 54.8 +/- 4.0% in hearts reperfused after 60 min of ischemia (n = 3) [2].
• Regional blood-to-tissue transport, expressed as a unidirectional transfer rate constant (K), was measured in experimental brain tumors using alpha-aminoisobutyric acid (AIB) labeled with carbon 14 and quantitative autoradiography [3].
• To develop a new approach to the diagnosis of herpes simplex encephalitis, we used a radiolabeled antiviral drug, 2'-fluoro-5-methyl-1-beta-D-arabinosyluracil labeled with carbon 14 ([14C]FMAU), as a probe for selectively imaging brain infection in a rat model by quantitative autoradiography [4].
• A total of 160 patients with dyspepsia and a Glasgow Dyspepsia Severity Score of at least 3 had a urea breath test labeled with carbon 14 [5].

Psychiatry related information on methane

• Use of bomb pulse carbon-14 to age senile plaques and neurofibrillary tangles in Alzheimer's disease [6].

High impact information on methane

• The evidence comes from a close correlation between inferred changes in production rates of the cosmogenic nuclides carbon-14 and beryllium-10 and centennial to millennial time scale changes in proxies of drift ice measured in deep-sea sediment cores [7].
• The rate of phosphorylation as determined by 31P NMR was consistent with results achieved by tracer methods using carbon-14-labeled 2-deoxyglucose [8].
• Barbiturate-enhanced detection of brain lesions by carbon-14-labeled 2-deoxyglucose autoradiography [9].
• In this experiment, vaginocervical stimulation produced statistically significant increases in the metabolic uptake of carbon-14-labeled 2-deoxy-D-glucose in the following brain areas (ordered by magnitude of uptake): medial preoptic, mesencephalic reticular formation, bed nucleus of stria terminalis, dorsal raphe, and globus pallidus [10].
• Kinetic analysis of the uptake of carbon-14-labeled oleate in a single-pass perfusion of rat liver and saturable and specific binding of iodine-125-labeled albumin to hepatocytes in suspension suggest the existence of a receptor for albumin on the liver cell surface [11].

Chemical compound and disease context of methane

• To determine the applicability of the tracer to measurement of permeability in the airways the diffusion and binding characteristics of 99mTc DTPA and the chemically related ethylenediaminetetra-acetic acid labelled with carbon-14 (14C EDTA) was studied in purified respiratory tract mucus glycoprotein from patients with chronic bronchitis [12].
• Regional CBF was measured with carbon-14-labeled iodoantipyrine autoradiography in normotensive baboons, in hypotensive animals, and in hypotensive animals with carotid artery occlusion or stenosis [13].
• Reduction of polychlorinated biphenyl toxicity and uptake of carbon-14 activity by plants through the use of activated carbon [14].

Biological context of methane

• Studies of the effect of the dopamine agonist apomorphine on local cerebral glucose utilization by means of the carbon-14-labeled deoxyglucose method demonstrate a dose-dependent metabolic activation in the superficial layer of the superior colliculus in the rat [15].
• Radioactive carbon dioxide (14CO2) exhalation was measured two hours after oral administration of a trace dose of carbon-14 labeled aminopyrine [16].
• Accelerator mass spectrometry is uniquely suited for assessing absorption and kinetics of carbon-14 ((14)C)-labeled substances after oral ingestion because it is more sensitive than decay counting and can measure levels of (14)C in microliter volumes of biological samples with negligible exposure of subjects to radioactivity [17].
• Evidence was obtained for a slower rate of alkylation at the alpha-position (carbon 14) of the ester group [18].
• Radionuclide-labelled solid meals were used to calculate gastric emptying times (GETs) and carbon-14 urea breath tests (14C UBTs) were used to measure the HP colonies quantitatively [19].

Anatomical context of methane

• We used the leukemic cell line CCRFCEM and its drug-resistant subline VBL(100) to measure the uptake of carbon 14 ((14)C)-labeled imatinib [20].
• The ESR hyperfine splittings of spin-labeled phospholipid probes revealed that alpha-synuclein induces chain ordering at carbon 14 of the acyl chains below the chain melting phase transition temperature but not in the liquid crystalline state of electroneutral vesicle membranes [21].
• Results showed that intact rabbit hearts and homogenates of rabbit left ventricle incorporate carbon-14-labeled ethanol at 20 and 59 nmol/g/h, respectively, into a neutral lipid species that co-migrates with triacylglycerides in standard chromatographic solvent systems [22].
• To investigate the relationships of local cerebral glucose utilization (lCMRgl) and blood flow (lCBF) during physiologic activation, awake Wistar rats received unilateral stimulation of the large facial whiskers (vibrissae) and were studied by carbon-14 double-label autoradiography [23].
• Quantitative autoradiography of parathyroid glands in rats with carbon-14-labeled amino acids [24].

Associations of methane with other chemical compounds

• Bile acid metabolism was also characterized by the breath test for deconjugation using carbon dioxide labeled with radioactive carbon 14 [25].
• Regional cerebral pH was determined autoradiographically using carbon 14-labeled dimethyloxazolidinedione in normal rats, following various durations of thiamine deficiency and replenishment with thiamine when the clinical sequelae of the deficiency appeared [26].
• Postwash retention of iodoantipyrine in carbon-14 double-label autoradiography [27].
• Quantitative double-tracer autoradiography with tritium and carbon-14 using imaging plates: application to myocardial metabolic studies in rats [28].
• Colestipol hydrochloride, a polymeric, ion-exchange type, hypocholesterolemic agent, acting by sequestering bile acids, was labeled with carbon-14 [29].

Gene context of methane

• INTERVENTIONS: Cytochrome P450 3A4 activity was estimated using the carbon-14 [14C]erythromycin breath test (ERMBT) before surgery and 24, 48, and 72 hrs after surgery [30].
• LTRvc was determined from the specific activity of carbon-14 [14C]lactate in aortic blood during a constant infusion of [14C]lactate into the inferior vena cava [31].
• Measurement of metabolite distribution was obtained using carbon-14-labeled deoxy-d-glucose and multiple strips of CR-39 (a solid nuclear track detector) placed sequentially in the catheter to measure the low energy beta emissions from the carbon-14 [32].
• Arginase activity was measured under physiologic conditions by the conversion carbon 14-labeled guanidino-L-arginine to carbon 14-labeled urea [33].
• Carbon-14 specific activity was similar in all particle sizes, and in indigestible and digestible NDF [34].

Analytical, diagnostic and therapeutic context of methane

• High-pressure liquid chromatography coupled with a radioactivity detector: investigation into the biotransformations of tritium and carbon-14 labeled compounds [35].
• Secondary ion mass spectrometry using in situ mass discrimination is proposed here as a very sensitive method which permits rapid imaging of the subcellular distribution of molecules labeled with carbon 14 [36].
• The disposition of carbon-14-labeled diethylene glycol (DEG) was determined in rats after oral, iv, and dermal administration, and in dogs after oral administration [37].
• Gamma-labeled microspheres were separated by a special technique from carbon-14 ([14C])-lidocaine in the same tissue sample [38].
• Following gel filtration chromatography of B fragilis culture filtrate, the fractions containing succinic acid labeled with carbon 14 inhibited PMN migration [39].

References