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Chemical Compound Review

carbane     methane

Synonyms: Carbon-14, CHEBI:36927, AC1L1C2B, (14)C, (14)6C, ...
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Disease relevance of methane

  • 2'-Fluoro-5-methyl-l-beta-D-arabinosyluracil (FMAU) labeled with carbon-14 was used to image herpes simplex virus type 1-infected regions of rat brain by quantitative autoradiography [1].
  • Results of initial experiments with carbon-14-labeled acetate (14C-acetate) indicated that the steady-state extraction fraction of acetate averaged 61.5 +/- 4.0% in control hearts (n = 4), 93.6 +/- 0.9% in hearts rendered ischemic (n = 4), and 54.8 +/- 4.0% in hearts reperfused after 60 min of ischemia (n = 3) [2].
  • Regional blood-to-tissue transport, expressed as a unidirectional transfer rate constant (K), was measured in experimental brain tumors using alpha-aminoisobutyric acid (AIB) labeled with carbon 14 and quantitative autoradiography [3].
  • To develop a new approach to the diagnosis of herpes simplex encephalitis, we used a radiolabeled antiviral drug, 2'-fluoro-5-methyl-1-beta-D-arabinosyluracil labeled with carbon 14 ([14C]FMAU), as a probe for selectively imaging brain infection in a rat model by quantitative autoradiography [4].
  • A total of 160 patients with dyspepsia and a Glasgow Dyspepsia Severity Score of at least 3 had a urea breath test labeled with carbon 14 [5].

Psychiatry related information on methane


High impact information on methane


Chemical compound and disease context of methane


Biological context of methane


Anatomical context of methane

  • We used the leukemic cell line CCRFCEM and its drug-resistant subline VBL(100) to measure the uptake of carbon 14 ((14)C)-labeled imatinib [20].
  • The ESR hyperfine splittings of spin-labeled phospholipid probes revealed that alpha-synuclein induces chain ordering at carbon 14 of the acyl chains below the chain melting phase transition temperature but not in the liquid crystalline state of electroneutral vesicle membranes [21].
  • Results showed that intact rabbit hearts and homogenates of rabbit left ventricle incorporate carbon-14-labeled ethanol at 20 and 59 nmol/g/h, respectively, into a neutral lipid species that co-migrates with triacylglycerides in standard chromatographic solvent systems [22].
  • To investigate the relationships of local cerebral glucose utilization (lCMRgl) and blood flow (lCBF) during physiologic activation, awake Wistar rats received unilateral stimulation of the large facial whiskers (vibrissae) and were studied by carbon-14 double-label autoradiography [23].
  • Quantitative autoradiography of parathyroid glands in rats with carbon-14-labeled amino acids [24].

Associations of methane with other chemical compounds


Gene context of methane

  • INTERVENTIONS: Cytochrome P450 3A4 activity was estimated using the carbon-14 [14C]erythromycin breath test (ERMBT) before surgery and 24, 48, and 72 hrs after surgery [30].
  • LTRvc was determined from the specific activity of carbon-14 [14C]lactate in aortic blood during a constant infusion of [14C]lactate into the inferior vena cava [31].
  • Measurement of metabolite distribution was obtained using carbon-14-labeled deoxy-d-glucose and multiple strips of CR-39 (a solid nuclear track detector) placed sequentially in the catheter to measure the low energy beta emissions from the carbon-14 [32].
  • Arginase activity was measured under physiologic conditions by the conversion carbon 14-labeled guanidino-L-arginine to carbon 14-labeled urea [33].
  • Carbon-14 specific activity was similar in all particle sizes, and in indigestible and digestible NDF [34].

Analytical, diagnostic and therapeutic context of methane


  1. Quantitative autoradiographic mapping of herpes simplex virus encephalitis with a radiolabeled antiviral drug. Saito, Y., Price, R.W., Rottenberg, D.A., Fox, J.J., Su, T.L., Watanabe, K.A., Philips, F.S. Science (1982) [Pubmed]
  2. Delineation of myocardial oxygen utilization with carbon-11-labeled acetate. Brown, M., Marshall, D.R., Sobel, B.E., Bergmann, S.R. Circulation (1987) [Pubmed]
  3. Regional blood-to-tissue transport in ethylnitrosourea-induced brain tumors. Blasberg, R.G., Kobayashi, T., Horowitz, M., Rice, J.M., Groothuis, D., Molnar, P., Fenstermacher, J.D. Ann. Neurol. (1983) [Pubmed]
  4. Diagnostic imaging of herpes simplex virus encephalitis using a radiolabeled antiviral drug: autoradiographic assessment in an animal model. Saito, Y., Rubenstein, R., Price, R.W., Fox, J.J., Watanabe, K.A. Ann. Neurol. (1984) [Pubmed]
  5. One-day quadruple therapy compared with 7-day triple therapy for Helicobacter pylori infection. Lara, L.F., Cisneros, G., Gurney, M., Van Ness, M., Jarjoura, D., Moauro, B., Polen, A., Rutecki, G., Whittier, F. Arch. Intern. Med. (2003) [Pubmed]
  6. Use of bomb pulse carbon-14 to age senile plaques and neurofibrillary tangles in Alzheimer's disease. Lovell, M.A., Robertson, J.D., Buchholz, B.A., Xie, C., Markesbery, W.R. Neurobiol. Aging (2002) [Pubmed]
  7. Persistent solar influence on North Atlantic climate during the Holocene. Bond, G., Kromer, B., Beer, J., Muscheler, R., Evans, M.N., Showers, W., Hoffmann, S., Lotti-Bond, R., Hajdas, I., Bonani, G. Science (2001) [Pubmed]
  8. Monitoring the time course of cerebral deoxyglucose metabolism by 31P nuclear magnetic resonance spectroscopy. Deuel, R.K., Yue, G.M., Sherman, W.R., Schickner, D.J., Ackerman, J.J. Science (1985) [Pubmed]
  9. Barbiturate-enhanced detection of brain lesions by carbon-14-labeled 2-deoxyglucose autoradiography. Frey, K.A., Agranoff, B.W. Science (1983) [Pubmed]
  10. Vaginocervical stimulation selectively increases metabolic activity in the rat brain. Allen, T.O., Adler, N.T., Greenberg, J.H., Reivich, M. Science (1981) [Pubmed]
  11. Receptor for albumin on the liver cell surface may mediate uptake of fatty acids and other albumin-bound substances. Weisiger, R., Gollan, J., Ockner, R. Science (1981) [Pubmed]
  12. Binding and diffusion characteristics of 14C EDTA and 99mTc DTPA in respiratory tract mucus glycoprotein from patients with chronic bronchitis. Cheema, M.S., Groth, S., Marriott, C. Thorax (1988) [Pubmed]
  13. The hemodynamic effects of internal carotid artery stenosis and occlusion. Mendelow, A.D., Graham, D.I., Tuor, U.I., Fitch, W. J. Neurosurg. (1987) [Pubmed]
  14. Reduction of polychlorinated biphenyl toxicity and uptake of carbon-14 activity by plants through the use of activated carbon. Strek, H.J., Weber, J.B., Shea, P.J., Mrozek, E., Overcash, M.R. J. Agric. Food Chem. (1981) [Pubmed]
  15. Retina-dependent activation by apomorphine of metabolic activity in the superficial layer of the superior colliculus. McCulloch, J., Savaki, H.E., McCulloch, M.C., Sokoloff, L. Science (1980) [Pubmed]
  16. Abnormal aminopyrine metabolism in patients with hepatic neoplasm. Detection by breath test. Hepner, G.W., Uhlin, S.R., Lipton, A., Harvey, H.A., Rohrer, V. JAMA (1976) [Pubmed]
  17. Human vitamin B12 absorption measurement by accelerator mass spectrometry using specifically labeled (14)C-cobalamin. Carkeet, C., Dueker, S.R., Lango, J., Buchholz, B.A., Miller, J.W., Green, R., Hammock, B.D., Roth, J.R., Anderson, P.J. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  18. Cancer chemopreventive 3-substituted-4-oxoretinoic acids. Shealy, Y.F., Hosmer, C.A., Riordan, J.M., Wille, J.W., Rogers, T.S., Hill, D.L. J. Med. Chem. (1994) [Pubmed]
  19. The relationship between Helicobacter pylori-associated gastritis or ulcer disease and gastric emptying. Kao, C.H., Wang, S.J., Chen, G.H., Yeh, S.H. European journal of nuclear medicine. (1994) [Pubmed]
  20. Active transport of imatinib into and out of cells: implications for drug resistance. Thomas, J., Wang, L., Clark, R.E., Pirmohamed, M. Blood (2004) [Pubmed]
  21. Binding of alpha-synuclein affects the lipid packing in bilayers of small vesicles. Kamp, F., Beyer, K. J. Biol. Chem. (2006) [Pubmed]
  22. Identification of fatty acid ethyl esters as products of rabbit myocardial ethanol metabolism. Lange, L.G., Bergmann, S.R., Sobel, B.E. J. Biol. Chem. (1981) [Pubmed]
  23. Coupled forebrain increases of local cerebral glucose utilization and blood flow during physiologic stimulation of a somatosensory pathway in the rat: demonstration by double-label autoradiography. Ginsberg, M.D., Dietrich, W.D., Busto, R. Neurology (1987) [Pubmed]
  24. Quantitative autoradiography of parathyroid glands in rats with carbon-14-labeled amino acids. Wortman, J.A., Alavi, A., Attie, M., Yudd, A.P., Johnston, S.A., Greenberg, J. J. Nucl. Med. (1987) [Pubmed]
  25. Effect of chenodiol on the small intestine. Unimpaired structure and function during therapy for gallstone dissolution. Casanova, S., Roda, A., Festi, D., Mazzella, G., Aldini, R., Bazzoli, F., Sama, C., Morselli, A.M., Barbara, L., Roda, E. JAMA (1981) [Pubmed]
  26. The induction and reversibility of cerebral acidosis in thiamine deficiency. Hakim, A.M. Ann. Neurol. (1984) [Pubmed]
  27. Postwash retention of iodoantipyrine in carbon-14 double-label autoradiography. Tanaka, K., Gotoh, F., Gomi, S., Takashima, S., Mihara, B. J. Cereb. Blood Flow Metab. (1987) [Pubmed]
  28. Quantitative double-tracer autoradiography with tritium and carbon-14 using imaging plates: application to myocardial metabolic studies in rats. Yamane, Y., Ishide, N., Kagaya, Y., Takeyama, D., Shiba, N., Chida, M., Sekiguchi, Y., Nozaki, T., Ido, T., Shirato, K. J. Nucl. Med. (1995) [Pubmed]
  29. Preparation of [14C]colestipol hydrochloride and its disposition in the human, dog and rat. Thomas, R.C., Hsi, R.S., Harpootlian, H., Johnson, T.D., Judy, R.W. Atherosclerosis (1978) [Pubmed]
  30. Cytochrome P450 3A4 activity after surgical stress. Haas, C.E., Kaufman, D.C., Jones, C.E., Burstein, A.H., Reiss, W. Crit. Care Med. (2003) [Pubmed]
  31. Endotoxin-induced hyperlactatemia results from decreased lactate clearance in hemodynamically stable rats. Severin, P.N., Uhing, M.R., Beno, D.W., Kimura, R.E. Crit. Care Med. (2002) [Pubmed]
  32. Monitoring substrate uptake and distribution by tumors using percutaneous catheters and solid nuclear track detectors. Gatenby, R.A. Investigative radiology. (1994) [Pubmed]
  33. Myometrial arginase activity increases with advancing pregnancy in the guinea pig. Weiner, C.P., Knowles, R.G., Stegink, L.D., Dawson, J., Moncada, S. Am. J. Obstet. Gynecol. (1996) [Pubmed]
  34. A review of the use of intrinsically 14C and rare earth-labeled neutral detergent fiber to estimate particle digestion and passage. Smith, L.W. J. Anim. Sci. (1989) [Pubmed]
  35. High-pressure liquid chromatography coupled with a radioactivity detector: investigation into the biotransformations of tritium and carbon-14 labeled compounds. Dugger, H.A., Orwig, B.A. Drug Metab. Rev. (1979) [Pubmed]
  36. Rapid localization of carbon 14-labeled molecules in biological samples by ion mass microscopy. Hindie, E., Escaig, F., Coulomb, B., Lebreton, C., Galle, P. J. Histochem. Cytochem. (1989) [Pubmed]
  37. Metabolism and disposition of diethylene glycol in rat and dog. Mathews, J.M., Parker, M.K., Matthews, H.B. Drug Metab. Dispos. (1991) [Pubmed]
  38. Spatial distribution of [14C]-lidocaine and blood flow in transmural and lateral border zones of ischemic canine myocardium. Patterson, R.E., Weintraub, W.S., Halgash, D.A., Miao, J., Rogers, J.R., Kupersmith, J. Am. J. Cardiol. (1982) [Pubmed]
  39. Succinic acid production by Bacteroides fragilis. A potential bacterial virulence factor. Rotstein, O.D., Wells, C.L., Pruett, T.L., Sorenson, J.J., Simmons, R.L. Archives of surgery (Chicago, Ill. : 1960) (1987) [Pubmed]
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