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Chemical Compound Review:

YIGSR (2S)-2-[[(2S)-2-[2-[[(2S,3S)- 2-[[(2S)-2...

Synonyms: SureCN2182807, T7154_SIGMA, AC1L3XNS, LS-172131, C26H42N8O8, ...

Massia, S.P. et al., Bauvois, B. et al., Kim, W.H. et al., Miyata, K. et al., Yamamoto, S. et al., et al.

Kouzi-Koliakos, Koliakos, Trontzos, Papageorgiou, Iliadis, Triantos, Dimitriadou, Kanellaki,

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Disease relevance of Tyr-ile-gly-ser-arg

Multimeric forms of Tyr-Ile-Gly-Ser-Arg (YIGSR) peptide enhance the inhibition of tumor growth and metastasis [1].
Apoptosis in human fibrosarcoma cells is induced by a multimeric synthetic Tyr-Ile-Gly-Ser-Arg (YIGSR)-containing polypeptide from laminin [2].
The laminin-derived peptide YIGSR (Tyr-Ile-Gly-Ser-Arg) inhibits human pre-B leukaemic cell growth and dissemination to organs in SCID mice [3].
Tyr-Ile-Gly-Ser-Arg (YIGSR), a laminin-derived peptide, conjugated with amino-PEG (YIGSR-aPEG) inhibited lung metastasis of B16-BL6 melanoma cells more effectively than unconjugated YIGSR peptide [4].

High impact information on Tyr-ile-gly-ser-arg

A synthetic peptide from the B1 chain of laminin, cyclic-YIGSR (Tyr-Ile-Gly-Ser-Arg), inhibited laminin-induced SCLC cell adhesion and migration in vitro and reduced the size of the tumors they formed when coinjected with matrigel and YIGSR [5].
The YIGSR (Tyr-Ile-Gly-Ser-Arg) peptide, derived from the laminin beta 1 chain, decreases tumor metastasis and growth in experimental animals [2].
The Tyr-Ile-Gly-Ser-Arg (YIGSR) peptide derived from the laminin B1 chain has been shown to decrease tumor growth and metastasis [1].
Covalently immobilized laminin peptide Tyr-Ile-Gly-Ser-Arg (YIGSR) supports cell spreading and co-localization of the 67-kilodalton laminin receptor with alpha-actinin and vinculin [6].
Anti-beta 1, anti-alpha 6, anti-alpha 2, and anti-alpha v mAb, as well as Tyr-Ile-Gly-Ser-Arg and Arg-Gly-Asp synthetic peptides from LM, had no effect on adhesion of PMA-stimulated cells on LM, implying that U937 cell adherence to LM is mediated through hitherto distinct receptors [7].

Chemical compound and disease context of Tyr-ile-gly-ser-arg

The Tyr-Ile-Gly-Ser-Arg (YIGSR) sequence on the B1 chain in laminin can decrease tumor growth and metastasis, whereas another sequence containing Ser-Ile-Lys-Val-Ala-Val (SIKVAV) on the A chain can increase tumor growth and metastasis [8].

Biological context of Tyr-ile-gly-ser-arg

The pentapeptide, Tyr-Ile-Gly-Ser-Arg, (YIGSR), an amino acid sequence from the B1 chain of laminin, was found to compete with laminin for binding to the laminin receptor [9].

Anatomical context of Tyr-ile-gly-ser-arg

In contrast, interaction of HT 29 cell membranes with the pentapeptide YIGSR (tyr-ile-gly-ser-arg), a sequence domain of the B1-chain of the laminin molecule, thought to be responsible for cell adhesion, was significantly weaker [10].
The attachment, spreading, spreading rate, focal contact formation, and cytoskeletal organization of human umbilical vein endothelial cells (HUVECs) were investigated on substrates that had been covalently grafted with the cell adhesion peptides Arg-Gly-Asp (RGD) and Tyr-Ile-Gly-Ser-Arg (YIGSR) [11].
It has been reported that metastatic melanoma cell lines selectively bind in vitro with the synthetic laminin pentapeptide tyrosyl-isoleucyl-glycyl-seryl-arginine (YIGSR) [12].

Associations of Tyr-ile-gly-ser-arg with other chemical compounds

Laminin-binding to germinating blastoconidia was inhibited by non-labelled laminin or fibrinogen but not by fibronectin, a fibronectin peptide (Gly-Arg-Gly-Asp-Ser), or a laminin peptide (Tyr-Ile-Gly-Ser-Arg) [13].

Gene context of Tyr-ile-gly-ser-arg

The synthetic laminin pentapeptide tyrosyl-isoleucyl-glycyl-seryl-arginine (YIGSR) binds to a metastasis associated high-affinity laminin receptor [14].
Inhibition of angiogenesis, tumour growth and experimental metastasis of human fibrosarcoma cells HT1080 by a multimeric form of the laminin sequence Tyr-Ile-Gly-Ser-Arg (YIGSR) [15].
We prepared three peptides derived from the type III connecting segment domain (IIICS) of fibronectin: Glu-Ile-Leu-Asp-Val (EILDV), Glu-Ile-Leu-Asp-Val-Pro-Ser-Thr (EILDVPST), Arg-Glu-Asp-Val (REDV), and a laminin-related peptide, Tyr-Ile-Gly-Ser-Arg (YIGSR) [16].
This binding can be inhibited competitively by a specific pentapeptide sequence (Tyr-Ile-Gly-Ser-Arg) of the laminin B1 chain, and this peptide can prevent metastasis formation in vivo [17].
In contrast, a mutein of TNF-alpha, designated as F4236, having the cell-adhesive sequence (Tyr-Ile-Gly-Ser-Arg) at the N-terminus of the TNF molecule did not enhance metastasis, but rather exhibited similar antitumor activity to wild-type TNF-alpha in fibrosarcoma-bearing mice [18].

References

Multimeric forms of Tyr-Ile-Gly-Ser-Arg (YIGSR) peptide enhance the inhibition of tumor growth and metastasis. Nomizu, M., Yamamura, K., Kleinman, H.K., Yamada, Y. Cancer Res. (1993) [Pubmed]
Apoptosis in human fibrosarcoma cells is induced by a multimeric synthetic Tyr-Ile-Gly-Ser-Arg (YIGSR)-containing polypeptide from laminin. Kim, W.H., Schnaper, H.W., Nomizu, M., Yamada, Y., Kleinman, H.K. Cancer Res. (1994) [Pubmed]
The laminin-derived peptide YIGSR (Tyr-Ile-Gly-Ser-Arg) inhibits human pre-B leukaemic cell growth and dissemination to organs in SCID mice. Yoshida, N., Ishii, E., Nomizu, M., Yamada, Y., Mohri, S., Kinukawa, N., Matsuzaki, A., Oshima, K., Hara, T., Miyazaki, S. Br. J. Cancer (1999) [Pubmed]
Synthetic cell-adhesive laminin peptide YIGSR conjugated with polyethylene glycol has improved antimetastatic activity due to a longer half-life in blood. Kaneda, Y., Yamamoto, S., Kihira, T., Tsutsumi, Y., Nakagawa, S., Miyake, M., Kawasaki, K., Mayumi, T. Invasion Metastasis (1995) [Pubmed]
Reconstituted basement membrane (matrigel) and laminin can enhance the tumorigenicity and the drug resistance of small cell lung cancer cell lines. Fridman, R., Giaccone, G., Kanemoto, T., Martin, G.R., Gazdar, A.F., Mulshine, J.L. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
Covalently immobilized laminin peptide Tyr-Ile-Gly-Ser-Arg (YIGSR) supports cell spreading and co-localization of the 67-kilodalton laminin receptor with alpha-actinin and vinculin. Massia, S.P., Rao, S.S., Hubbell, J.A. J. Biol. Chem. (1993) [Pubmed]
IFN-gamma and transforming growth factor-beta 1 differently regulate fibronectin and laminin receptors of human differentiating monocytic cells. Bauvois, B., Rouillard, D., Sanceau, J., Wietzerbin, J. J. Immunol. (1992) [Pubmed]
Melanoma cells selected for adhesion to laminin peptides have different malignant properties. Yamamura, K., Kibbey, M.C., Kleinman, H.K. Cancer Res. (1993) [Pubmed]
A CHARMM analysis of the conformations of the metastasis-inhibiting laminin pentapeptide. McKelvey, D.R., Brooks, C.L., Mokotoff, M. J. Protein Chem. (1991) [Pubmed]
Identification of laminin binding proteins in cell membranes of a human colon adenocarcinoma cell line. Stallmach, A., Schuppan, D., Dax, J., Hanski, C., Riecken, E.O. Gut (1990) [Pubmed]
Human endothelial cell interactions with surface-coupled adhesion peptides on a nonadhesive glass substrate and two polymeric biomaterials. Massia, S.P., Hubbell, J.A. J. Biomed. Mater. Res. (1991) [Pubmed]
In vivo binding of the radioiodinated peptide YIGSR on B16 melanoma cells. Kouzi-Koliakos, K., Koliakos, G., Trontzos, C., Papageorgiou, A., Iliadis, S., Triantos, A., Dimitriadou, A., Kanellaki, M. Invasion Metastasis (1996) [Pubmed]
Identification of a 21 kDa laminin-binding component of Candida albicans. Sakata, N., Yamazaki, K., Kogure, T. Zentralbl. Bakteriol. (1999) [Pubmed]
Lung carcinoma imaging using a synthetic laminin derivative radioiodinated peptide YIGSR. Koliakos, G., Trontzos, C., Kouzi-Koliakos, K., Kanellaki, M., Grammaticos, P. J. Nucl. Med. (1997) [Pubmed]
Inhibition of angiogenesis, tumour growth and experimental metastasis of human fibrosarcoma cells HT1080 by a multimeric form of the laminin sequence Tyr-Ile-Gly-Ser-Arg (YIGSR). Iwamoto, Y., Nomizu, M., Yamada, Y., Ito, Y., Tanaka, K., Sugioka, Y. Br. J. Cancer (1996) [Pubmed]
Antimetastatic effects of synthetic peptides containing the core sequence of the type III connecting segment domain (IIICS) of fibronectin. Yamamoto, S., Kaneda, Y., Okada, N., Nakagawa, S., Kubo, K., Inoue, S., Maeda, M., Yamashiro, Y., Kawasaki, K., Mayumi, T. Anticancer Drugs (1994) [Pubmed]
Conformation of the metastasis-inhibiting laminin pentapeptide. Brandt-Rauf, P.W., Pincus, M.R., Carty, R.P., Lubowsky, J., Avitable, M., Carucci, J., Murphy, R.B. J. Protein Chem. (1989) [Pubmed]
A YIGSR-containing novel mutein without the detrimental effect of human TNF-alpha of enhancing experimental pulmonary metastasis. Miyata, K., Kato, M., Shikama, H., Nishimura, K., Sakae, N., Kawagoe, K., Nishikawa, T., Kuroda, K., Yamaguchi, K., Aoyama, Y. Clin. Exp. Metastasis (1992) [Pubmed]

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