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Chemical Compound Review

YIGSR     (2S)-2-[[(2S)-2-[2-[[(2S,3S)- 2-[[(2S)-2...

Synonyms: SureCN2182807, T7154_SIGMA, AC1L3XNS, LS-172131, C26H42N8O8, ...
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Disease relevance of Tyr-ile-gly-ser-arg


High impact information on Tyr-ile-gly-ser-arg


Chemical compound and disease context of Tyr-ile-gly-ser-arg


Biological context of Tyr-ile-gly-ser-arg


Anatomical context of Tyr-ile-gly-ser-arg


Associations of Tyr-ile-gly-ser-arg with other chemical compounds


Gene context of Tyr-ile-gly-ser-arg


  1. Multimeric forms of Tyr-Ile-Gly-Ser-Arg (YIGSR) peptide enhance the inhibition of tumor growth and metastasis. Nomizu, M., Yamamura, K., Kleinman, H.K., Yamada, Y. Cancer Res. (1993) [Pubmed]
  2. Apoptosis in human fibrosarcoma cells is induced by a multimeric synthetic Tyr-Ile-Gly-Ser-Arg (YIGSR)-containing polypeptide from laminin. Kim, W.H., Schnaper, H.W., Nomizu, M., Yamada, Y., Kleinman, H.K. Cancer Res. (1994) [Pubmed]
  3. The laminin-derived peptide YIGSR (Tyr-Ile-Gly-Ser-Arg) inhibits human pre-B leukaemic cell growth and dissemination to organs in SCID mice. Yoshida, N., Ishii, E., Nomizu, M., Yamada, Y., Mohri, S., Kinukawa, N., Matsuzaki, A., Oshima, K., Hara, T., Miyazaki, S. Br. J. Cancer (1999) [Pubmed]
  4. Synthetic cell-adhesive laminin peptide YIGSR conjugated with polyethylene glycol has improved antimetastatic activity due to a longer half-life in blood. Kaneda, Y., Yamamoto, S., Kihira, T., Tsutsumi, Y., Nakagawa, S., Miyake, M., Kawasaki, K., Mayumi, T. Invasion Metastasis (1995) [Pubmed]
  5. Reconstituted basement membrane (matrigel) and laminin can enhance the tumorigenicity and the drug resistance of small cell lung cancer cell lines. Fridman, R., Giaccone, G., Kanemoto, T., Martin, G.R., Gazdar, A.F., Mulshine, J.L. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  6. Covalently immobilized laminin peptide Tyr-Ile-Gly-Ser-Arg (YIGSR) supports cell spreading and co-localization of the 67-kilodalton laminin receptor with alpha-actinin and vinculin. Massia, S.P., Rao, S.S., Hubbell, J.A. J. Biol. Chem. (1993) [Pubmed]
  7. IFN-gamma and transforming growth factor-beta 1 differently regulate fibronectin and laminin receptors of human differentiating monocytic cells. Bauvois, B., Rouillard, D., Sanceau, J., Wietzerbin, J. J. Immunol. (1992) [Pubmed]
  8. Melanoma cells selected for adhesion to laminin peptides have different malignant properties. Yamamura, K., Kibbey, M.C., Kleinman, H.K. Cancer Res. (1993) [Pubmed]
  9. A CHARMM analysis of the conformations of the metastasis-inhibiting laminin pentapeptide. McKelvey, D.R., Brooks, C.L., Mokotoff, M. J. Protein Chem. (1991) [Pubmed]
  10. Identification of laminin binding proteins in cell membranes of a human colon adenocarcinoma cell line. Stallmach, A., Schuppan, D., Dax, J., Hanski, C., Riecken, E.O. Gut (1990) [Pubmed]
  11. Human endothelial cell interactions with surface-coupled adhesion peptides on a nonadhesive glass substrate and two polymeric biomaterials. Massia, S.P., Hubbell, J.A. J. Biomed. Mater. Res. (1991) [Pubmed]
  12. In vivo binding of the radioiodinated peptide YIGSR on B16 melanoma cells. Kouzi-Koliakos, K., Koliakos, G., Trontzos, C., Papageorgiou, A., Iliadis, S., Triantos, A., Dimitriadou, A., Kanellaki, M. Invasion Metastasis (1996) [Pubmed]
  13. Identification of a 21 kDa laminin-binding component of Candida albicans. Sakata, N., Yamazaki, K., Kogure, T. Zentralbl. Bakteriol. (1999) [Pubmed]
  14. Lung carcinoma imaging using a synthetic laminin derivative radioiodinated peptide YIGSR. Koliakos, G., Trontzos, C., Kouzi-Koliakos, K., Kanellaki, M., Grammaticos, P. J. Nucl. Med. (1997) [Pubmed]
  15. Inhibition of angiogenesis, tumour growth and experimental metastasis of human fibrosarcoma cells HT1080 by a multimeric form of the laminin sequence Tyr-Ile-Gly-Ser-Arg (YIGSR). Iwamoto, Y., Nomizu, M., Yamada, Y., Ito, Y., Tanaka, K., Sugioka, Y. Br. J. Cancer (1996) [Pubmed]
  16. Antimetastatic effects of synthetic peptides containing the core sequence of the type III connecting segment domain (IIICS) of fibronectin. Yamamoto, S., Kaneda, Y., Okada, N., Nakagawa, S., Kubo, K., Inoue, S., Maeda, M., Yamashiro, Y., Kawasaki, K., Mayumi, T. Anticancer Drugs (1994) [Pubmed]
  17. Conformation of the metastasis-inhibiting laminin pentapeptide. Brandt-Rauf, P.W., Pincus, M.R., Carty, R.P., Lubowsky, J., Avitable, M., Carucci, J., Murphy, R.B. J. Protein Chem. (1989) [Pubmed]
  18. A YIGSR-containing novel mutein without the detrimental effect of human TNF-alpha of enhancing experimental pulmonary metastasis. Miyata, K., Kato, M., Shikama, H., Nishimura, K., Sakae, N., Kawagoe, K., Nishikawa, T., Kuroda, K., Yamaguchi, K., Aoyama, Y. Clin. Exp. Metastasis (1992) [Pubmed]
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