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Gene Review

LAMB1  -  laminin, beta 1

Homo sapiens

Synonyms: CLM, LIS5, Laminin B1 chain, Laminin subunit beta-1, Laminin-1 subunit beta, ...
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Disease relevance of LAMB1

  • These results suggested that alteration of LAMB1 expression is associated with the genesis and development of uterine leiomyoma [1].
  • On the basis of these results we suggested that one of the eight genome RNA segments of influenza virus codes for two polypeptides [Lamb, R.A., Etkind, P.R. & Choppin, P.W. (1978) Virology 91, 60-78] [2].
  • Genes of laminin B1 chain, alpha 1 (IV) chain of type IV collagen, and 72-kd type IV collagenase are mainly expressed by the stromal cells of lung carcinomas [3].
  • In this study, we analyzed the expression of messenger (m)RNAs for laminin B1 chain, alpha 1 (IV) chain of type IV collagen, and 72-kd type IV collagenase in 15 primary lung carcinomas and in two metastatic adenocarcinomas to the lung [3].
  • This suggests that the RSV F glycoprotein contains a domain that closely resembles the core structure of the simian parainfluenza virus 5 fusion protein (K. A. Baker, R. E. Dutch, R. A. Lamb, and T. S. Jardetzky, Mol. Cell 3:309-319, 1999) [4].

Psychiatry related information on LAMB1

  • The stability of individual differences in infant attachment: comments on the Thompson, Lamb, and Estes contribution [5].
  • Recently, differential UCS expectancies were found for high- and low-predatory fear-relevant animals [Davey, G. C. L., Cavanagh, K., & Lamb, A. (2003). Differential aversive outcome expectancies for high- and low-predation fear-relevant animals. Journal of Behavior Therapy and Experimental Psychiatry, 34, 117-128] [6].
  • A possible answer to these problems is to establish institutionalized outpatient facilities in the "hybrid" gap between the legal and mental health system (Lamb, Weinberger, & Gross, 1988) [7].

High impact information on LAMB1


Chemical compound and disease context of LAMB1

  • Unexpectedly, a mutation of glycine residues in the FP of the fusion (F) protein from the paramyxovirus simian parainfluenza virus 5 (SV5) resulted in mutant F proteins with hyperactive fusion phenotypes (C. M. Horvath and R. A. Lamb, J. Virol. 66:2443-2455, 1992) [13].
  • This binding can be inhibited competitively by a specific pentapeptide sequence (Tyr-Ile-Gly-Ser-Arg) of the laminin B1 chain, and this peptide can prevent metastasis formation in vivo [14].

Biological context of LAMB1


Anatomical context of LAMB1

  • In a proportion of tumors, mRNAs for laminin B1 chain and 72-kd type IV collagenase could also be observed in carcinoma cells, but the amount of mRNAs was considerably lower in them than in the stromal cells [3].
  • In the case of viral antigen presentation to class II MHC-restricted T lymphocytes, there is strong, albeit indirect, evidence for processing of antigen and recognition of fragments of viral polypeptides (Lamb et al. 1982, Hackett et al. 1983).(ABSTRACT TRUNCATED AT 400 WORDS)[19]
  • Previously we determined that the transferrin-independent transport system was present on a wide variety of cultured cells (Sturrock, A., Alexander, J., Lamb, J., Craven, C. M., and Kaplan, J. (1990) J. Biol. Chem. 265, 3139-3145) [20].
  • In this study we investigated the mRNA expressions of 72 kD and 92 kD type IV collagenases, alpha 1(IV) chain of type IV collagen, and laminin B1 chain mRNAs in a set of malignant and benign salivary gland tumours and compared the results with non-neoplastic salivary gland tissue [21].
  • RESULTS: The reduction of laminin B1 chain and the overexpression of the S chain, a homologue of B1, in the extrajunctional basal lamina were observed in the five patients who had advanced clinical symptoms and histopathologic changes [22].

Associations of LAMB1 with chemical compounds

  • Quantum electrodynamics in strong electric fields: the ground-state Lamb shift in hydrogenlike uranium [23].
  • In this issue of Chemistry & Biology, the identification and application of a glycopeptide-specific sulfotransferase by Lamb et al. expands the tool box of biocombinatorial synthesis [24].
  • Mammalian cells accumulate iron from ferric citrate or ferric nitrilotriacetate through the activity of a transferrin-independent iron transport system [Sturrock, Alexander, Lamb, Craven and Kaplan (1990) J. Biol. Chem. 265, 3139-3145] [25].
  • The suggestion that the ethanol regulatory protein from Aspergillus has its evolutionary origin in a gene fusion between aldehyde and alcohol dehydrogenase genes (Hawkins AR, Lamb HK, Radford A, Moore JD, 1994, Gene 146:145-158) has been tested by profile analysis with aldehyde and alcohol dehydrogenase family profiles [26].
  • These antibodies, which did not react with the laminin E8 fragment, were directed against epitopes in the NH2-terminus of the laminin B1-chain and in the central region of laminin [27].

Other interactions of LAMB1


Analytical, diagnostic and therapeutic context of LAMB1

  • Richard Lamb has proposed a program of aggressive outreach and psychiatric hospitalization for the homeless mentally ill [31].
  • This modeling technique enabled studying the influence of the transducer characteristics on the Lamb waves propagating in orthotropic plates [32].
  • First, the water loading effects on the free plate Lamb modes in acrylic and human cortical bone plates were examined [33].
  • This article describes two potentially practical implementations of Lamb wave tomographic imaging techniques that can be optimized for in-the-field testing of large-area aircraft structures [34].
  • Jack pine (Pinus banksiana Lamb.), hybrid poplar (Populus deltoides Bartr. ex Marsh. xPopulus nigra L.) and red clover (Trifolium pratense L.) plants were used in an 8-week greenhouse bioassay to evaluate the mycorrhizal inoculum potential of CT [35].


  1. Genes associated with the genesis of leiomyoma of the uterus in a commonly deleted chromosomal region at 7q22. Saito, E., Okamoto, A., Saito, M., Shinozaki, H., Takakura, S., Yanaihara, N., Ochiai, K., Tanaka, T. Oncol. Rep. (2005) [Pubmed]
  2. Segment 8 of the influenza virus genome is unique in coding for two polypeptides. Lamb, R.A., Choppin, P.W. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  3. Genes of laminin B1 chain, alpha 1 (IV) chain of type IV collagen, and 72-kd type IV collagenase are mainly expressed by the stromal cells of lung carcinomas. Soini, Y., Pääkkö, P., Autio-Harmainen, H. Am. J. Pathol. (1993) [Pubmed]
  4. The core of the respiratory syncytial virus fusion protein is a trimeric coiled coil. Matthews, J.M., Young, T.F., Tucker, S.P., Mackay, J.P. J. Virol. (2000) [Pubmed]
  5. The stability of individual differences in infant attachment: comments on the Thompson, Lamb, and Estes contribution. Waters, E. Child development. (1983) [Pubmed]
  6. Differential UCS expectancy bias in spider fearful individuals: evidence toward an association between spiders and disgust-relevant outcomes. van Overveld, M., de Jong, P.J., Peters, M.L. Journal of behavior therapy and experimental psychiatry. (2006) [Pubmed]
  7. Outpatient treatment of mentally disordered offenders in Austria. Knecht, G., Schanda, H., Berner, W., Morawitz, I., Haubenstock, E. International journal of law and psychiatry. (1996) [Pubmed]
  8. Type 1 neurofibromatosis: selective expression of extracellular matrix genes by Schwann cells, perineurial cells, and fibroblasts in mixed cultures. Jaakkola, S., Peltonen, J., Riccardi, V., Chu, M.L., Uitto, J. J. Clin. Invest. (1989) [Pubmed]
  9. Role of laminin and basement membrane in the morphological differentiation of human endothelial cells into capillary-like structures. Kubota, Y., Kleinman, H.K., Martin, G.R., Lawley, T.J. J. Cell Biol. (1988) [Pubmed]
  10. Isolation of a cDNA clone for the human laminin-B1 chain and its gene localization. Jaye, M., Modi, W.S., Ricca, G.A., Mudd, R., Chiu, I.M., O'Brien, S.J., Drohan, W.N. Am. J. Hum. Genet. (1987) [Pubmed]
  11. Human myofibroblastlike cells obtained by outgrowth are representative of the fibrogenic cells in the liver. Blazejewski, S., Preaux, A.M., Mallat, A., Brocheriou, I., Mavier, P., Dhumeaux, D., Hartmann, D., Schuppan, D., Rosenbaum, J. Hepatology (1995) [Pubmed]
  12. Influenza virus M2 protein slows traffic along the secretory pathway. pH perturbation of acidified compartments affects early Golgi transport steps. Henkel, J.R., Weisz, O.A. J. Biol. Chem. (1998) [Pubmed]
  13. Conserved glycine residues in the fusion peptide of the paramyxovirus fusion protein regulate activation of the native state. Russell, C.J., Jardetzky, T.S., Lamb, R.A. J. Virol. (2004) [Pubmed]
  14. Conformation of the metastasis-inhibiting laminin pentapeptide. Brandt-Rauf, P.W., Pincus, M.R., Carty, R.P., Lubowsky, J., Avitable, M., Carucci, J., Murphy, R.B. J. Protein Chem. (1989) [Pubmed]
  15. Human laminin B1 chain. A multidomain protein with gene (LAMB1) locus in the q22 region of chromosome 7. Pikkarainen, T., Eddy, R., Fukushima, Y., Byers, M., Shows, T., Pihlajaniemi, T., Saraste, M., Tryggvason, K. J. Biol. Chem. (1987) [Pubmed]
  16. Examination of NRCAM, LRRN3, KIAA0716, and LAMB1 as autism candidate genes. Hutcheson, H.B., Olson, L.M., Bradford, Y., Folstein, S.E., Santangelo, S.L., Sutcliffe, J.S., Haines, J.L. BMC Med. Genet. (2004) [Pubmed]
  17. A novel locus for autosomal-dominant dilated cardiomyopathy maps to chromosome 7q22.3-31.1. Schönberger, J., Kühler, L., Martins, E., Lindner, T.H., Silva-Cardoso, J., Zimmer, M. Hum. Genet. (2005) [Pubmed]
  18. A novel laminin B1 chain variant in avian eye. O'Rear, J.J. J. Biol. Chem. (1992) [Pubmed]
  19. Antigen presentation pathways to class I and class II MHC-restricted T lymphocytes. Braciale, T.J., Morrison, L.A., Sweetser, M.T., Sambrook, J., Gething, M.J., Braciale, V.L. Immunol. Rev. (1987) [Pubmed]
  20. Regulation of the transferrin-independent iron transport system in cultured cells. Kaplan, J., Jordan, I., Sturrock, A. J. Biol. Chem. (1991) [Pubmed]
  21. Synthesis and degradation of basement membranes in benign and malignant salivary gland tumours. A study by in situ hybridization. Soini, Y., Autio-Harmainen, H. J. Pathol. (1993) [Pubmed]
  22. Laminin abnormality in severe childhood autosomal recessive muscular dystrophy. Yamada, H., Tomé, F.M., Higuchi, I., Kawai, H., Azibi, K., Chaouch, M., Roberds, S.L., Tanaka, T., Fujita, S., Mitsui, T. Lab. Invest. (1995) [Pubmed]
  23. Quantum electrodynamics in strong electric fields: the ground-state Lamb shift in hydrogenlike uranium. Gumberidze, A., Stöhlker, T., Banaś, D., Beckert, K., Beller, P., Beyer, H.F., Bosch, F., Hagmann, S., Kozhuharov, C., Liesen, D., Nolden, F., Ma, X., Mokler, P.H., Steck, M., Sierpowski, D., Tashenov, S. Phys. Rev. Lett. (2005) [Pubmed]
  24. Sulfation: a new biocombinatorial tool. Pelzer, S., Dziarnowski, A. Chem. Biol. (2006) [Pubmed]
  25. The mammalian transferrin-independent iron transport system may involve a surface ferrireductase activity. Jordan, I., Kaplan, J. Biochem. J. (1994) [Pubmed]
  26. Ethanol utilization regulatory protein: profile alignments give no evidence of origin through aldehyde and alcohol dehydrogenase gene fusion. Nicholas, H.B., Persson, B., Jörnvall, H., Hempel, J. Protein Sci. (1995) [Pubmed]
  27. Heterotrimeric configuration is essential to the adhesive function of laminin. Lissitzky, J.C., Cantau, P., Martin, P.M. J. Cell. Biochem. (1992) [Pubmed]
  28. Cloning of the beta 3 chain gene (LAMB3) of human laminin 5, a candidate gene in junctional epidermolysis bullosa. Pulkkinen, L., Gerecke, D.R., Christiano, A.M., Wagman, D.W., Burgeson, R.E., Uitto, J. Genomics (1995) [Pubmed]
  29. A new nomenclature for the laminins. Burgeson, R.E., Chiquet, M., Deutzmann, R., Ekblom, P., Engel, J., Kleinman, H., Martin, G.R., Meneguzzi, G., Paulsson, M., Sanes, J. Matrix Biol. (1994) [Pubmed]
  30. Structure of the human laminin B2 chain gene reveals extensive divergence from the laminin B1 chain gene. Kallunki, T., Ikonen, J., Chow, L.T., Kallunki, P., Tryggvason, K. J. Biol. Chem. (1991) [Pubmed]
  31. Psychiatry and the homeless mentally ill: a reply to Dr. Lamb. Mossman, D., Perlin, M.L. The American journal of psychiatry. (1992) [Pubmed]
  32. Design of optimal configuration for generating A0 Lamb mode in a composite plate using piezoceramic transducers. Grondel, S., Paget, C., Delebarre, C., Assaad, J., Levin, K. The Journal of the Acoustical Society of America. (2002) [Pubmed]
  33. Ultrasonic propagation in cortical bone mimics. Dodd, S.P., Cunningham, J.L., Miles, A.W., Gheduzzi, S., Humphrey, V.F. Physics in medicine and biology. (2006) [Pubmed]
  34. Fan beam and double crosshole Lamb wave tomography for mapping flaws in aging aircraft structures. Malyarenko, E.V., Hinders, M.K. The Journal of the Acoustical Society of America. (2000) [Pubmed]
  35. Mycorrhizal inoculum potentials of pure reclamation materials and revegetated tailing sands from the Canadian oil sand industry. Bois, G., Piché, Y., Fung, M.Y., Khasa, D.P. Mycorrhiza (2005) [Pubmed]
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