Disease relevance of LAMB1

• These results suggested that alteration of LAMB1 expression is associated with the genesis and development of uterine leiomyoma [1].
• On the basis of these results we suggested that one of the eight genome RNA segments of influenza virus codes for two polypeptides [Lamb, R.A., Etkind, P.R. & Choppin, P.W. (1978) Virology 91, 60-78] [2].
• Genes of laminin B1 chain, alpha 1 (IV) chain of type IV collagen, and 72-kd type IV collagenase are mainly expressed by the stromal cells of lung carcinomas [3].
• In this study, we analyzed the expression of messenger (m)RNAs for laminin B1 chain, alpha 1 (IV) chain of type IV collagen, and 72-kd type IV collagenase in 15 primary lung carcinomas and in two metastatic adenocarcinomas to the lung [3].
• This suggests that the RSV F glycoprotein contains a domain that closely resembles the core structure of the simian parainfluenza virus 5 fusion protein (K. A. Baker, R. E. Dutch, R. A. Lamb, and T. S. Jardetzky, Mol. Cell 3:309-319, 1999) [4].

Psychiatry related information on LAMB1

• The stability of individual differences in infant attachment: comments on the Thompson, Lamb, and Estes contribution [5].
• Recently, differential UCS expectancies were found for high- and low-predatory fear-relevant animals [Davey, G. C. L., Cavanagh, K., & Lamb, A. (2003). Differential aversive outcome expectancies for high- and low-predation fear-relevant animals. Journal of Behavior Therapy and Experimental Psychiatry, 34, 117-128] [6].
• A possible answer to these problems is to establish institutionalized outpatient facilities in the "hybrid" gap between the legal and mental health system (Lamb, Weinberger, & Gross, 1988) [7].

High impact information on LAMB1

• In situ hybridizations revealed that all three cell types expressed pro alpha 1 (I), pro alpha 2 (VI), and laminin B1 chain genes [8].
• Preincubation of endothelial cells with synthetic peptides derived from the laminin B1 chain that bind to the laminin cell surface receptor or incorporation of these peptides into the gel matrix blocked tubule formation, whereas control peptides did not [9].
• With use of this probe and a panel of rodent/human somatic-cell hybrids and in situ hybridization, the gene for the human laminin-B1 chain has been localized to chromosome 7, band q31 [10].
• They also expressed mRNAs for laminin B1 chain and for cellular and plasma fibronectin [11].
• Recombinant M2 slows protein traffic through the Golgi complex (Sakaguchi, T., Leser, G. P)., and Lamb, R [12].

Chemical compound and disease context of LAMB1

• Unexpectedly, a mutation of glycine residues in the FP of the fusion (F) protein from the paramyxovirus simian parainfluenza virus 5 (SV5) resulted in mutant F proteins with hyperactive fusion phenotypes (C. M. Horvath and R. A. Lamb, J. Virol. 66:2443-2455, 1992) [13].
• This binding can be inhibited competitively by a specific pentapeptide sequence (Tyr-Ile-Gly-Ser-Arg) of the laminin B1 chain, and this peptide can prevent metastasis formation in vivo [14].

Biological context of LAMB1

• Using somatic cell hybrid methodology and in situ hybridization to metaphase chromosomes it was established that the human laminin B1 gene (LAMB1) is located in the q22 region of chromosome 7 [15].
• However, with LAMB1, the allelic association analysis revealed suggestive evidence for a positive association, including one individual SNP (p = 0.02) and three separate two-SNP haplotypes across the gene (p = 0.007, 0.012, and 0.012) [16].
• Coding exons of the candidate genes LAMB1, LAMB4 and PIK3CG were screened but no mutations were identified [17].
• We report the isolation and characterization of six overlapping cDNA clones that provide the first and complete amino acid sequence of the human laminin B1 chain [15].
• DNA sequence analysis identified one cDNA as the chicken homologue of the prototypic EHS laminin B1 chain [18].

Anatomical context of LAMB1

• In a proportion of tumors, mRNAs for laminin B1 chain and 72-kd type IV collagenase could also be observed in carcinoma cells, but the amount of mRNAs was considerably lower in them than in the stromal cells [3].
• In the case of viral antigen presentation to class II MHC-restricted T lymphocytes, there is strong, albeit indirect, evidence for processing of antigen and recognition of fragments of viral polypeptides (Lamb et al. 1982, Hackett et al. 1983).(ABSTRACT TRUNCATED AT 400 WORDS)[19]
• Previously we determined that the transferrin-independent transport system was present on a wide variety of cultured cells (Sturrock, A., Alexander, J., Lamb, J., Craven, C. M., and Kaplan, J. (1990) J. Biol. Chem. 265, 3139-3145) [20].
• In this study we investigated the mRNA expressions of 72 kD and 92 kD type IV collagenases, alpha 1(IV) chain of type IV collagen, and laminin B1 chain mRNAs in a set of malignant and benign salivary gland tumours and compared the results with non-neoplastic salivary gland tissue [21].
• RESULTS: The reduction of laminin B1 chain and the overexpression of the S chain, a homologue of B1, in the extrajunctional basal lamina were observed in the five patients who had advanced clinical symptoms and histopathologic changes [22].

Associations of LAMB1 with chemical compounds

• Quantum electrodynamics in strong electric fields: the ground-state Lamb shift in hydrogenlike uranium [23].
• In this issue of Chemistry & Biology, the identification and application of a glycopeptide-specific sulfotransferase by Lamb et al. expands the tool box of biocombinatorial synthesis [24].
• Mammalian cells accumulate iron from ferric citrate or ferric nitrilotriacetate through the activity of a transferrin-independent iron transport system [Sturrock, Alexander, Lamb, Craven and Kaplan (1990) J. Biol. Chem. 265, 3139-3145] [25].
• The suggestion that the ethanol regulatory protein from Aspergillus has its evolutionary origin in a gene fusion between aldehyde and alcohol dehydrogenase genes (Hawkins AR, Lamb HK, Radford A, Moore JD, 1994, Gene 146:145-158) has been tested by profile analysis with aldehyde and alcohol dehydrogenase family profiles [26].
• These antibodies, which did not react with the laminin E8 fragment, were directed against epitopes in the NH2-terminus of the laminin B1-chain and in the central region of laminin [27].

Other interactions of LAMB1

• Comparison of the LAMB3 gene structure with the previously characterized LAMB1 gene revealed that LAMB3 was considerably more compact [28].
• The genes for these chains are LAMA1, LAMB1 and LAMC1, respectively [29].
• Structure of the human laminin B2 chain gene reveals extensive divergence from the laminin B1 chain gene [30].

Analytical, diagnostic and therapeutic context of LAMB1

• Richard Lamb has proposed a program of aggressive outreach and psychiatric hospitalization for the homeless mentally ill [31].
• This modeling technique enabled studying the influence of the transducer characteristics on the Lamb waves propagating in orthotropic plates [32].
• First, the water loading effects on the free plate Lamb modes in acrylic and human cortical bone plates were examined [33].
• This article describes two potentially practical implementations of Lamb wave tomographic imaging techniques that can be optimized for in-the-field testing of large-area aircraft structures [34].
• Jack pine (Pinus banksiana Lamb.), hybrid poplar (Populus deltoides Bartr. ex Marsh. xPopulus nigra L.) and red clover (Trifolium pratense L.) plants were used in an 8-week greenhouse bioassay to evaluate the mycorrhizal inoculum potential of CT [35].

References