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Chemical Compound Review

Sikvav     (2S)-6-amino-N-[(1S)-1- [[(1S)-1-[[(1S)-1...

Synonyms: AC1NUPJX, AG-D-90356, CTK4C4834, 146163-06-6, Ser-ile-lys-val-ala-val, ...
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Disease relevance of Sikvav


High impact information on Sikvav

  • PURPOSE: Our purpose was to use an in vivo murine model system to study the angiogenic activity of a synthetic peptide derived from the laminin A protein chain and containing the SIKVAV amino acid sequence [1].
  • METHODS: The SIKVAV-containing peptide was mixed with Matrigel, a reconstituted basement membrane extract used to assay stimulation of angiogenesis [1].
  • We show that synthetic cell-adhesion peptide sequences present in laminin 1 (RGD and YIGSR) or an antibody to the cell-binding domain (SIKVAV) of the alpha 1 chain do not prevent hepatocyte adhesion to LBP [6].
  • Peptides derived from the beta1 chain of laminin had no effect on macrophage uPA expression, whereas SIKVAV, derived from alpha1 chain, stimulated uPA expression 20-fold [7].
  • Peptides that contained either the Drosophila sequence SIKVGV or the murine homologue, SIKVAV, provided support for neurite extension [8].

Biological context of Sikvav

  • Coating the culture dishes with the laminin peptides RGD, YIGSR, and SIKVAV supported the attachment of HUVECs that was unaffected by glycosylation [9].
  • These data suggest that neutrophils are induced to migrate to the Matrigel plugs, at least in part, by SIKVAV peptide, where they may release their own angiogenic factors and degrade the matrix, thus physically facilitating cell migration and liberating additional angiogenic matrix fragments and/or cytokines [10].
  • In vitro experiments utilizing human neutrophils demonstrated that these cells migrate to the SIKVAV peptide and possess a specific cell surface SIKVAV binding protein of approximately 56 kD [10].
  • Since implants serve as recording sensors in prosthetic neuroscience, we investigated whether coating electrodes with certain laminin derivatives containing the peptide sequences SIKVAV, CDPGYIGSR, PDSGR, YFQRYLI, and RNIAEIIKDA influences neuronal adhesion and neurite outgrowth in vitro [11].

Anatomical context of Sikvav

  • If adherent monocytes were exposed to SIKVAV in the presence of ConA, this peptide enhanced the ConA induced production of these mediators [12].
  • We found that neutrophils are continuously recruited to the SIKVAV-containing plugs between 4 hours to 3 days following the initial injection [10].
  • These cells also produced factors in response to SIKVAV peptide which induced proliferation of human umbilical vein endothelial cells relative to a control peptide [10].
  • In cells cultured on the peptides derived from laminin (RGD and SIKVAV), FSH increased the uptake of 45Ca significantly, whereas on YIGSR, also a laminin-derived peptide, it did not have any effect [13].
  • When small GC pins were implanted into the brain of E17 chicken after coating with the 18-mer SIKVAV peptide, nerve cell attachment was observed in vivo [11].

Associations of Sikvav with other chemical compounds

  • Laminin SIKVAV peptide induction of monocyte/macrophage prostaglandin E2 and matrix metalloproteinases [12].
  • Repeating this experiment with medium containing equivalent amounts of purified laminin, a major component of Matrigel, or with YIGSR or SIKVAV, two peptides known to mimic various activities of laminin, similarly restored phenobarbital responsiveness to hepatocytes cultured on Vitrogen [14].
  • Embryonic (E18) hippocampal neurons were cultured in serum-free medium for up to 1 week on FEP film surfaces that were modified with either one or both of GYIGSR and SIKVAV or GGGGGGYIGSR and compared to control surfaces of FEP-[N/O] and poly(L-lysine)/laminin-coated tissue culture polystyrene [15].

Gene context of Sikvav

  • Laminin peptides YIGRS and SIKVAV, which impaired tubule formation on Matrigel without inducing cell spreading or monolayer formation, partially impaired cell spreading upon Trx-treated Matrigel without restoring tubule formation, consistent with a potential role for laminin in Trx-mediated effects [16].
  • Its murine counterpart carries the sequence SIKVAV by which the interaction of laminin and cells is mediated [17].
  • Revascularization of ischemic tissues with SIKVAV and neuropeptide Y (NPY) [18].
  • Immunohistochemistry and zymography suggested that SIKVAV enhanced the secretion of MMP-2 and MMP-9 in CAC2 cells [19].
  • Interaction of endothelial cells with a laminin A chain peptide (SIKVAV) in vitro and induction of angiogenic behavior in vivo [20].

Analytical, diagnostic and therapeutic context of Sikvav

  • Western blot analysis of lung CM revealed the presence of some laminin fragments containing the sequence SIKVAV [21].
  • Both compounds (500 micrograms SIKVAV and 10 ng of NPY) were embedded in the rat hind limb following unilateral ligation of the femoral artery 1 cm proximal to the adductor hiatus [18].


  1. Role of the SIKVAV site of laminin in promotion of angiogenesis and tumor growth: an in vivo Matrigel model. Kibbey, M.C., Grant, D.S., Kleinman, H.K. J. Natl. Cancer Inst. (1992) [Pubmed]
  2. Melanoma cells selected for adhesion to laminin peptides have different malignant properties. Yamamura, K., Kibbey, M.C., Kleinman, H.K. Cancer Res. (1993) [Pubmed]
  3. The laminins: a family of basement membrane glycoproteins important in cell differentiation and tumor metastases. Kleinman, H.K., Weeks, B.S., Schnaper, H.W., Kibbey, M.C., Yamamura, K., Grant, D.S. Vitam. Horm. (1993) [Pubmed]
  4. The effect of laminin and its peptide SIKVAV on a human salivary gland myoepithelioma cell line. Capuano, A.C., Jaeger, R.G. Oral Oncol. (2004) [Pubmed]
  5. SIKVAV, a laminin alpha1-derived peptide, interacts with integrins and increases protease activity of a human salivary gland adenoid cystic carcinoma cell line through the ERK 1/2 signaling pathway. Freitas, V.M., Vilas-Boas, V.F., Pimenta, D.C., Loureiro, V., Juliano, M.A., Carvalho, M.R., Pinheiro, J.J., Camargo, A.C., Moriscot, A.S., Hoffman, M.P., Jaeger, R.G. Am. J. Pathol. (2007) [Pubmed]
  6. Rat hepatocytes attach to laminin present in liver biomatrix proteins by an Mg(++)-dependent mechanism. Ponce, M.L., Rojkind, M. Hepatology (1995) [Pubmed]
  7. Role of laminin in matrix induction of macrophage urokinase-type plasminogen activator and 92-kDa metalloproteinase expression. Khan, K.M., Falcone, D.J. J. Biol. Chem. (1997) [Pubmed]
  8. Conserved neuron promoting activity in Drosophila and vertebrate laminin alpha1. Takagi, Y., Nomizu, M., Gullberg, D., MacKrell, A.J., Keene, D.R., Yamada, Y., Fessler, J.H. J. Biol. Chem. (1996) [Pubmed]
  9. Inhibition of endothelial cell differentiation on a glycosylated reconstituted basement membrane complex. Kuzuya, M., Satake, S., Miura, H., Hayashi, T., Iguchi, A. Exp. Cell Res. (1996) [Pubmed]
  10. Laminin SIKVAV peptide-induced angiogenesis in vivo is potentiated by neutrophils. Kibbey, M.C., Corcoran, M.L., Wahl, L.M., Kleinman, H.K. J. Cell. Physiol. (1994) [Pubmed]
  11. Modification of glassy carbon surfaces with synthetic laminin-derived peptides for nerve cell attachment and neurite growth. Huber, M., Heiduschka, P., Kienle, S., Pavlidis, C., Mack, J., Walk, T., Jung, G., Thanos, S. J. Biomed. Mater. Res. (1998) [Pubmed]
  12. Laminin SIKVAV peptide induction of monocyte/macrophage prostaglandin E2 and matrix metalloproteinases. Corcoran, M.L., Kibbey, M.C., Kleinman, H.K., Wahl, L.M. J. Biol. Chem. (1995) [Pubmed]
  13. Rat Sertoli cell calcium response to basement membrane and follicle-stimulating hormone. Ravindranath, N., Papadopoulos, V., Brooker, G., Dym, M. Biol. Reprod. (1996) [Pubmed]
  14. Critical role of extracellular matrix on induction by phenobarbital of cytochrome P450 2B1/2 in primary cultures of adult rat hepatocytes. Brown, S.E., Guzelian, C.P., Schuetz, E., Quattrochi, L.C., Kleinman, H.K., Guzelian, P.S. Lab. Invest. (1995) [Pubmed]
  15. Enhancing the neuronal interaction on fluoropolymer surfaces with mixed peptides or spacer group linkers. Tong, Y.W., Shoichet, M.S. Biomaterials (2001) [Pubmed]
  16. Thioredoxin inhibits microvascular endothelial capillary tubule formation. Farina, A.R., Tacconelli, A., Cappabianca, L., DeSantis, G., Gulino, A., Mackay, A.R. Exp. Cell Res. (2003) [Pubmed]
  17. Active sites in the carboxyl-terminal region of the laminin alpha chain in Drosophila neuronal cell spreading. Takagi, Y., Nomizu, M., Ui-Tei, K., Tokushige, N., Hirohashi, S. Arch. Insect Biochem. Physiol. (2004) [Pubmed]
  18. Revascularization of ischemic tissues with SIKVAV and neuropeptide Y (NPY). Grant, D.S., Zukowska, Z. Adv. Exp. Med. Biol. (2000) [Pubmed]
  19. Laminin-1 and SIKVAV a laminin-1-derived peptide, regulate the morphology and protease activity of a human salivary gland adenoid cystic carcinoma cell line. Freitas, V.M., Scheremeta, B., Hoffman, M.P., Jaeger, R.G. Oral Oncol. (2004) [Pubmed]
  20. Interaction of endothelial cells with a laminin A chain peptide (SIKVAV) in vitro and induction of angiogenic behavior in vivo. Grant, D.S., Kinsella, J.L., Fridman, R., Auerbach, R., Piasecki, B.A., Yamada, Y., Zain, M., Kleinman, H.K. J. Cell. Physiol. (1992) [Pubmed]
  21. Soluble factors from the target organ enhance tumor cell angiogenesis: role of laminin SIKVAV sequence. Davel, L.E., Puricelli, L.I., Del Carmen C Vidal, M., De Lorenzo, M.S., Sacerdote de Lustig, E., Bal de Kier Joffe, E.D. Oncol. Rep. (1999) [Pubmed]
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