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Chemical Compound Review

AC1Q5WHI     2-[methyl-[(4R)-4- [(3R,5S,7R,10S,12S,13R...

Synonyms: AR-1K7719, 93790-70-6, Cholylsarcosine
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Disease relevance of Cholylsarcosine

  • When a [3H]triolein emulsion with either cholylsarcosine or cholyltaurine was infused intraduodenally in biliary fistula rats, recovery of 3H in lymph was 52 +/- 10% (mean +/- SD) for cholylsarcosine and 52 +/- 11% for cholyltaurine [1].
  • This study compared the effect of a natural conjugated bile acid mixture from ox bile with that of cholylsarcosine, a synthetic conjugated bile acid, on fat absorption and diarrhea in a patient with the short-bowel syndrome [2].
  • Endotoxemia was decreased in cirrhotic rats by conjugated bile acid feeding (cholylsarcosine, 0.098 +/- 0.002; cholylglycine 0.101 +/- 0.007 EU/mL) compared with placebo (0.282 +/- 0.124, P <.001) [3].
  • Rats with CCl(4)-induced cirrhosis and ascites were fed cholylsarcosine, cholylglycine (both at 70 mg/kg/d), or placebo for 2 weeks [3].
  • Cholylsarcosine, a new conjugated bile acid analogue that has been developed as a bile acid replacement agent, improves lipid absorption in animals with steatorrhea caused by bile acid malabsorption and intestinal resection [4].

High impact information on Cholylsarcosine


Chemical compound and disease context of Cholylsarcosine


Biological context of Cholylsarcosine


Anatomical context of Cholylsarcosine

  • Absorption of cholylsarcosine was much greater from the ileal segment (28-fold that of the duodenum under control conditions) and was enhanced with 1,25(OH)(2)D(3) treatment [10].

Gene context of Cholylsarcosine

  • The physiological relevance of ASBT induction by 1,25(OH)(2)D(3) was assessed by measuring absorption of cholylsarcosine, a non-metabolized synthetic bile acid analog, from duodenal or ileal closed loops of the perfused rat small intestine preparation [10].
  • Treatment with cholylsarcosine increased absorption of C14:0 by 23%-29%, of C16:0 by 59%-74%, of C18:0 by 125%-138%, and of unsaturated C18-fatty acids by 36%-45% [7].

Analytical, diagnostic and therapeutic context of Cholylsarcosine


  1. Physicochemical and physiological properties of cholylsarcosine. A potential replacement detergent for bile acid deficiency states in the small intestine. Lillienau, J., Schteingart, C.D., Hofmann, A.F. J. Clin. Invest. (1992) [Pubmed]
  2. Conjugated bile acid replacement therapy for short-bowel syndrome. Gruy-Kapral, C., Little, K.H., Fordtran, J.S., Meziere, T.L., Hagey, L.R., Hofmann, A.F. Gastroenterology (1999) [Pubmed]
  3. Oral bile acids reduce bacterial overgrowth, bacterial translocation, and endotoxemia in cirrhotic rats. Lorenzo-Zúñiga, V., Bartolí, R., Planas, R., Hofmann, A.F., Viñado, B., Hagey, L.R., Hernández, J.M., Mañé, J., Alvarez, M.A., Ausina, V., Gassull, M.A. Hepatology (2003) [Pubmed]
  4. Defective biliary secretion during total parenteral nutrition: probable mechanisms and possible solutions. Hofmann, A.F. J. Pediatr. Gastroenterol. Nutr. (1995) [Pubmed]
  5. Cholylsarcosine, a new bile acid analogue: metabolism and effect on biliary secretion in humans. Schmassmann, A., Fehr, H.F., Locher, J., Lillienau, J., Schteingart, C.D., Rossi, S.S., Hofmann, A.F. Gastroenterology (1993) [Pubmed]
  6. Transport, metabolism, and effect of chronic feeding of cholylsarcosine, a conjugated bile acid resistant to deconjugation and dehydroxylation. Schmassmann, A., Angellotti, M.A., Ton-Nu, H.T., Schteingart, C.D., Marcus, S.N., Rossi, S.S., Hofmann, A.F. Gastroenterology (1990) [Pubmed]
  7. Bile acid replacement therapy with cholylsarcosine for short-bowel syndrome. Heydorn, S., Jeppesen, P.B., Mortensen, P.B. Scand. J. Gastroenterol. (1999) [Pubmed]
  8. Adjuvant cholylsarcosine during ursodeoxycholic acid treatment of primary biliary cirrhosis. Ricci, P., Hofmann, A.F., Hagey, L.R., Jorgensen, R.A., Rolland Dickson, E., Lindor, K.D. Dig. Dis. Sci. (1998) [Pubmed]
  9. Improvement of intestinal peptide absorption by a synthetic bile acid derivative, cholylsarcosine. Michael, S., Thöle, M., Dillmann, R., Fahr, A., Drewe, J., Fricker, G. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. (2000) [Pubmed]
  10. Transactivation of rat apical sodium-dependent bile acid transporter and increased bile acid transport by 1alpha,25-dihydroxyvitamin D3 via the vitamin D receptor. Chen, X., Chen, F., Liu, S., Glaeser, H., Dawson, P.A., Hofmann, A.F., Kim, R.B., Shneider, B.L., Pang, K.S. Mol. Pharmacol. (2006) [Pubmed]
  11. Effect of replacement therapy with cholylsarcosine on fat malabsorption associated with severe bile acid malabsorption. Studies in dogs with ileal resection. Longmire-Cook, S.J., Lillienau, J., Kim, Y.S., Schteingart, C.D., Danzinger, R.G., Esch, O., Hofmann, A.F. Dig. Dis. Sci. (1992) [Pubmed]
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