The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

AC1Q5WHI     2-[methyl-[(4R)-4- [(3R,5S,7R,10S,12S,13R...

Synonyms: AR-1K7719, 93790-70-6, Cholylsarcosine
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Cholylsarcosine

  • When a [3H]triolein emulsion with either cholylsarcosine or cholyltaurine was infused intraduodenally in biliary fistula rats, recovery of 3H in lymph was 52 +/- 10% (mean +/- SD) for cholylsarcosine and 52 +/- 11% for cholyltaurine [1].
  • This study compared the effect of a natural conjugated bile acid mixture from ox bile with that of cholylsarcosine, a synthetic conjugated bile acid, on fat absorption and diarrhea in a patient with the short-bowel syndrome [2].
  • Endotoxemia was decreased in cirrhotic rats by conjugated bile acid feeding (cholylsarcosine, 0.098 +/- 0.002; cholylglycine 0.101 +/- 0.007 EU/mL) compared with placebo (0.282 +/- 0.124, P <.001) [3].
  • Rats with CCl(4)-induced cirrhosis and ascites were fed cholylsarcosine, cholylglycine (both at 70 mg/kg/d), or placebo for 2 weeks [3].
  • Cholylsarcosine, a new conjugated bile acid analogue that has been developed as a bile acid replacement agent, improves lipid absorption in animals with steatorrhea caused by bile acid malabsorption and intestinal resection [4].
 

High impact information on Cholylsarcosine

 

Chemical compound and disease context of Cholylsarcosine

 

Biological context of Cholylsarcosine

 

Anatomical context of Cholylsarcosine

  • Absorption of cholylsarcosine was much greater from the ileal segment (28-fold that of the duodenum under control conditions) and was enhanced with 1,25(OH)(2)D(3) treatment [10].
 

Gene context of Cholylsarcosine

  • The physiological relevance of ASBT induction by 1,25(OH)(2)D(3) was assessed by measuring absorption of cholylsarcosine, a non-metabolized synthetic bile acid analog, from duodenal or ileal closed loops of the perfused rat small intestine preparation [10].
  • Treatment with cholylsarcosine increased absorption of C14:0 by 23%-29%, of C16:0 by 59%-74%, of C18:0 by 125%-138%, and of unsaturated C18-fatty acids by 36%-45% [7].
 

Analytical, diagnostic and therapeutic context of Cholylsarcosine

References

  1. Physicochemical and physiological properties of cholylsarcosine. A potential replacement detergent for bile acid deficiency states in the small intestine. Lillienau, J., Schteingart, C.D., Hofmann, A.F. J. Clin. Invest. (1992) [Pubmed]
  2. Conjugated bile acid replacement therapy for short-bowel syndrome. Gruy-Kapral, C., Little, K.H., Fordtran, J.S., Meziere, T.L., Hagey, L.R., Hofmann, A.F. Gastroenterology (1999) [Pubmed]
  3. Oral bile acids reduce bacterial overgrowth, bacterial translocation, and endotoxemia in cirrhotic rats. Lorenzo-Zúñiga, V., Bartolí, R., Planas, R., Hofmann, A.F., Viñado, B., Hagey, L.R., Hernández, J.M., Mañé, J., Alvarez, M.A., Ausina, V., Gassull, M.A. Hepatology (2003) [Pubmed]
  4. Defective biliary secretion during total parenteral nutrition: probable mechanisms and possible solutions. Hofmann, A.F. J. Pediatr. Gastroenterol. Nutr. (1995) [Pubmed]
  5. Cholylsarcosine, a new bile acid analogue: metabolism and effect on biliary secretion in humans. Schmassmann, A., Fehr, H.F., Locher, J., Lillienau, J., Schteingart, C.D., Rossi, S.S., Hofmann, A.F. Gastroenterology (1993) [Pubmed]
  6. Transport, metabolism, and effect of chronic feeding of cholylsarcosine, a conjugated bile acid resistant to deconjugation and dehydroxylation. Schmassmann, A., Angellotti, M.A., Ton-Nu, H.T., Schteingart, C.D., Marcus, S.N., Rossi, S.S., Hofmann, A.F. Gastroenterology (1990) [Pubmed]
  7. Bile acid replacement therapy with cholylsarcosine for short-bowel syndrome. Heydorn, S., Jeppesen, P.B., Mortensen, P.B. Scand. J. Gastroenterol. (1999) [Pubmed]
  8. Adjuvant cholylsarcosine during ursodeoxycholic acid treatment of primary biliary cirrhosis. Ricci, P., Hofmann, A.F., Hagey, L.R., Jorgensen, R.A., Rolland Dickson, E., Lindor, K.D. Dig. Dis. Sci. (1998) [Pubmed]
  9. Improvement of intestinal peptide absorption by a synthetic bile acid derivative, cholylsarcosine. Michael, S., Thöle, M., Dillmann, R., Fahr, A., Drewe, J., Fricker, G. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. (2000) [Pubmed]
  10. Transactivation of rat apical sodium-dependent bile acid transporter and increased bile acid transport by 1alpha,25-dihydroxyvitamin D3 via the vitamin D receptor. Chen, X., Chen, F., Liu, S., Glaeser, H., Dawson, P.A., Hofmann, A.F., Kim, R.B., Shneider, B.L., Pang, K.S. Mol. Pharmacol. (2006) [Pubmed]
  11. Effect of replacement therapy with cholylsarcosine on fat malabsorption associated with severe bile acid malabsorption. Studies in dogs with ileal resection. Longmire-Cook, S.J., Lillienau, J., Kim, Y.S., Schteingart, C.D., Danzinger, R.G., Esch, O., Hofmann, A.F. Dig. Dis. Sci. (1992) [Pubmed]
 
WikiGenes - Universities