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Chemical Compound Review

AAAT     pyrimidine-2,4,6-triamine

Synonyms: PubChem7216, SureCN96485, CHEMBL571518, CPD-9357, ACMC-1BR5S, ...
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Disease relevance of NSC 26493

  • Cl- fluxes conform to the flux-ratio equation and were reduced by anoxia or 2,4,6-triaminopyrimidine but were not affected by 4-acetamido-4'-isothiocynostilbene-2,2'-disulfonic acid (SITS) [1].

High impact information on NSC 26493


Biological context of NSC 26493


Anatomical context of NSC 26493


Associations of NSC 26493 with other chemical compounds


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  2. Effect of protonated 2,4,6-triaminopyrimidine, a tight junction blocker, on intestinal transport in dog ileum in vivo. Krejs, G.J., Seelig, L.L., Fordtran, J.S. Gastroenterology (1977) [Pubmed]
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  7. Non-classical antifolates, 5-(N-phenylpyrrolidin-3-yl)-2,4,6-triaminopyrimidines and 2,4-Diamino-6(5H)-oxopyrimidines, synthesis and antitumor studies. Huang, Y.L., Lin, C.F., Lee, Y.J., Li, W.W., Chao, T.C., Bacherikov, V.A., Chen, K.T., Chen, C.M., Su, T.L. Bioorg. Med. Chem. (2003) [Pubmed]
  8. Noise analysis of the K+ current through the apical membrane of Necturus gallbladder. Gögelein, H., Van Driessche, W. J. Membr. Biol. (1981) [Pubmed]
  9. Failure of 2,4,6-triaminopyrimidine (TAP) to block sodium pathways in a "leaky" epithelium: the urinary bladder of the trout. Fossat, B., Lahlou, B. Pflugers Arch. (1979) [Pubmed]
  10. Blocking by 2,4,6-triaminopyrimidine of increased tight junction permeability induced by acetylcholine in the pancreas. Jansen, J.W., Fleuren-Jakobs, A.M., De Pont, J.J., Bonting, S.L. Biochim. Biophys. Acta (1980) [Pubmed]
  11. In vivo sugar diffusion in the ileal epithelium of spontaneously hypertensive rats. Mate, A., Gómez-Amores, L., Vázquez, C.M., Bolufer, J. Scand. J. Gastroenterol. (2003) [Pubmed]
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