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Chemical Compound Review

AAAT     pyrimidine-2,4,6-triamine

Synonyms: PubChem7216, SureCN96485, CHEMBL571518, CPD-9357, ACMC-1BR5S, ...
 
 
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Disease relevance of NSC 26493

  • Cl- fluxes conform to the flux-ratio equation and were reduced by anoxia or 2,4,6-triaminopyrimidine but were not affected by 4-acetamido-4'-isothiocynostilbene-2,2'-disulfonic acid (SITS) [1].
 

High impact information on NSC 26493

 

Biological context of NSC 26493

 

Anatomical context of NSC 26493

 

Associations of NSC 26493 with other chemical compounds

References

  1. Alkaline secretion by amphibian duodenum. II. Short-circuit current and Na+ and Cl- fluxes. Simson, J.N., Merhav, A., Silen, W. Am. J. Physiol. (1981) [Pubmed]
  2. Effect of protonated 2,4,6-triaminopyrimidine, a tight junction blocker, on intestinal transport in dog ileum in vivo. Krejs, G.J., Seelig, L.L., Fordtran, J.S. Gastroenterology (1977) [Pubmed]
  3. Proteinase-activated receptor-2-induced colonic inflammation in mice: possible involvement of afferent neurons, nitric oxide, and paracellular permeability. Cenac, N., Garcia-Villar, R., Ferrier, L., Larauche, M., Vergnolle, N., Bunnett, N.W., Coelho, A.M., Fioramonti, J., Bueno, L. J. Immunol. (2003) [Pubmed]
  4. Effects of 2,4,6-triaminopyrimidine on the electromechanical properties of guinea-pig myocardium. Frank, M., Flom, L.L. J. Pharmacol. Exp. Ther. (1978) [Pubmed]
  5. Noise analysis of the K+ current through the apical membrane of Necturus gallbladder. Gögelein, H., Van Driessche, W. J. Membr. Biol. (1981) [Pubmed]
  6. Alteration of sodium conductance of feline choroid plexus: effect of 2,4,6-triaminopyrimidine and tetrodotoxin. Eisenberg, H.M., Welch, K. Brain Res. (1976) [Pubmed]
  7. Non-classical antifolates, 5-(N-phenylpyrrolidin-3-yl)-2,4,6-triaminopyrimidines and 2,4-Diamino-6(5H)-oxopyrimidines, synthesis and antitumor studies. Huang, Y.L., Lin, C.F., Lee, Y.J., Li, W.W., Chao, T.C., Bacherikov, V.A., Chen, K.T., Chen, C.M., Su, T.L. Bioorg. Med. Chem. (2003) [Pubmed]
  8. Noise analysis of the K+ current through the apical membrane of Necturus gallbladder. Gögelein, H., Van Driessche, W. J. Membr. Biol. (1981) [Pubmed]
  9. Failure of 2,4,6-triaminopyrimidine (TAP) to block sodium pathways in a "leaky" epithelium: the urinary bladder of the trout. Fossat, B., Lahlou, B. Pflugers Arch. (1979) [Pubmed]
  10. Blocking by 2,4,6-triaminopyrimidine of increased tight junction permeability induced by acetylcholine in the pancreas. Jansen, J.W., Fleuren-Jakobs, A.M., De Pont, J.J., Bonting, S.L. Biochim. Biophys. Acta (1980) [Pubmed]
  11. In vivo sugar diffusion in the ileal epithelium of spontaneously hypertensive rats. Mate, A., Gómez-Amores, L., Vázquez, C.M., Bolufer, J. Scand. J. Gastroenterol. (2003) [Pubmed]
 
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