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Chemical Compound Review

anhydride     trioxochromium

Synonyms: Chromtrioxid, Chroomtrioxyde, CrO3, chromic acie, CCRIS 160, ...
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Disease relevance of trioxochromium


High impact information on trioxochromium

  • Six major glycosphingolipids (A-F) from monohexosylceramide to pentahexosylceramide were identified by sugar composition analysis, methylation analysis, secondary ion-mass spectrometry, glycosidase digestion, and chromium trioxide oxidation [4].
  • The effect of chlorophyllin on micronucleated polychromatic erythrocytes (MN-PCE) induction by chromium trioxide (CrO(3)) exposure in peripheral blood of mice was studied [5].
  • Based on the results of immunological assays, partial acid hydrolysis, sequential degradation with specific exoglycosidases, oxidation with periodate and chromium trioxide, and permethylation analysis, we suggest that the carbohydrate chain of this fucolipid contains four termini [6].
  • The identification of oligosaccharides along with methylation analysis and chromic anhydride oxidation showed that the polysaccharide was built up of the repeating pentasaccharide units whose proposed structure is given below: (see article) Serological properties of Sh. dysenteriae O-specific polysaccharides are discussed [7].
  • We performed a 90-day repeated-dose inhalation toxicity study of soluble hexavalent chromium trioxide (CrO3 (VI)) [1].

Biological context of trioxochromium

  • By infrared spectroscopy, proton magnetic resonance spectroscopy, periodate oxidation, solvolysis, chromium trioxide oxidation, and methylation analysis of the native and partially degraded compound, the structure of this glycolipid is proposed to be GalNAc beta 1--4(HSO3-3)Gal beta 1--4Glc beta 1--1Cer [8].
  • The structure of this glycolipid was identified by partial acid hydrolysis, oxidation with periodate and chromium trioxide, and permethylation studies, as: SO3H-6Glcalphal leads to 6Glcalphal leads to 6Glcalphal leads to 3-diglyceride [9].
  • Prior work has demonstrated that chromium trioxide is embryotoxic in hamsters if administered to pregnant animals early on the eighth gestation day [2].
  • The structure of the carbohydrate moiety in the macroglycolipid was analyzed by methylation analysis, Smith degradation, nitrous acid deamination, and chromium trioxide oxidation [10].
  • Inhibition of repair of radiation-induced chromosome breaks: effects of chromium trioxide on cultured human lymphocytes [11].

Anatomical context of trioxochromium


Associations of trioxochromium with other chemical compounds


Gene context of trioxochromium

  • According to our results, chromium levels in plasma and urine in the order of 10 and 40 micrograms/l seem to correspond to an external exposure of 100 micrograms chromium trioxide per cubic metre, the technical guiding concentration (TRK-value) [19].

Analytical, diagnostic and therapeutic context of trioxochromium


  1. Subchronic inhalation toxicity of soluble hexavalent chromium trioxide in rats. Kim, H.Y., Lee, S.B., Jang, B.S. Arch. Toxicol. (2004) [Pubmed]
  2. The effect of the time of administration of chromium trioxide on the embryotoxic response in hamsters. Gale, T.F., Bunch, J.D. Teratology (1979) [Pubmed]
  3. Structural studies of the O-antigen polysaccharides of Klebsiella O5 and Escherichia coli O8. Jansson, P.E., Lönngren, J., Widmalm, G., Leontein, K., Slettengren, K., Svenson, S.B., Wrangsell, G., Dell, A., Tiller, P.R. Carbohydr. Res. (1985) [Pubmed]
  4. Characterization of neutral glycosphingolipids in human cataractous lens. Ogiso, M., Irie, A., Kubo, H., Komoto, M., Matsuno, T., Koide, Y., Hoshi, M. J. Biol. Chem. (1993) [Pubmed]
  5. Effect of chlorophyllin on chromium trioxide-induced micronuclei in polychromatic erythrocytes in mouse peripheral blood. García-Rodríguez, M.C., López-Santiago, V., Altamirano-Lozano, M. Mutat. Res. (2001) [Pubmed]
  6. Complex fucolipids of hog gastric mucosa. Structure of the ceramide eikosahexoside. Slomiany, B.L., Slomiany, A., Galicki, N.I., Kojima, K. Eur. J. Biochem. (1980) [Pubmed]
  7. Somatic antigens of Shigella. Structural investigation on the O-specific polysaccharide chain of Shigella dysenteriae type-2 lipopolysaccharide. Dmitriev, B.A., Knirel, Y.A., Kochetkov, N.K., Hofman, I.L., Capek, K. Eur. J. Biochem. (1977) [Pubmed]
  8. Isolation and characterization of the sulfated gangliotriaosylceramide from rat kidney. Tadano, K., Ishizuka, I. J. Biol. Chem. (1982) [Pubmed]
  9. Glycolipids of the human gastric content. Structure of the sulfated glyceroglucolipid. Slomiany, B.L., Slomiany, A., Glass, G.B. Eur. J. Biochem. (1977) [Pubmed]
  10. Isolation and partial structural characterization of macroglycolipid from rabbit erythrocyte membranes. Honma, K., Manabe, H., Tomita, M., Hamada, A. J. Biochem. (1981) [Pubmed]
  11. Inhibition of repair of radiation-induced chromosome breaks: effects of chromium trioxide on cultured human lymphocytes. Morimoto, K., Koizumi, A. Industrial health. (1981) [Pubmed]
  12. Derivation and study of human epithelial cell lines resistant to killing by chromium trioxide. Son, K.H., Zhang, M., Rucobo, E., Nwaigwe, D., Montgomery, F., Leffert, H. J. Toxicol. Environ. Health Part A (2004) [Pubmed]
  13. Studies on glycosphingolipids of fresh-water bivalves. III. Isolation and characterization of a novel globoside containing mannose from spermatozoa of the fresh-water bivalve, Hyriopsis schlegelii. Hori, T., Sugita, M., Kanbayashi, J., Itasaka, O. J. Biochem. (1977) [Pubmed]
  14. Toxicity of hexavalent chromium to the alveolar macrophage in vivo and in vitro. Galvin, J.B., Oberg, S.G. Environmental research. (1984) [Pubmed]
  15. Determination of the anomeric configurations of Corbicula ceramide di- and trihexoside by chromium trioxide oxidation. Itasaka, O., Sugita, M., Yoshizaki, H., Hori, T. J. Biochem. (1976) [Pubmed]
  16. Chromium carcinogenicity; a review of experimental animal data. Langård, S. Sci. Total Environ. (1988) [Pubmed]
  17. Studies on glycosphingolipids of larvae of the green-bottle fly, Lucilia caesar. I. Isolation and characterization of glycosphingolipids having novel sugar sequences. Sugita, M., Nishida, M., Hori, T. J. Biochem. (1982) [Pubmed]
  18. Alkali-labile oligosaccharide units of a sialoglycoprotein from rabbit erythrocyte membranes. Fukuda, K., Honma, K., Manabe, H., Utsumi, H., Hamada, A. Biochim. Biophys. Acta (1987) [Pubmed]
  19. Occupational chronic exposure to metals. I. Chromium exposure of stainless steel welders--biological monitoring. Angerer, J., Amin, W., Heinrich-Ramm, R., Szadkowski, D., Lehnert, G. International archives of occupational and environmental health. (1987) [Pubmed]
  20. Steroid metabolism in teleost gonads: purification and identification of metabolites by high-performance liquid chromatography. Venkatesh, B., Tan, C.H., Kime, D.E., Lam, T.J. Steroids (1992) [Pubmed]
  21. Chemical structure of the core region of Campylobacter jejuni serotype O:2 lipopolysaccharide. Aspinall, G.O., McDonald, A.G., Raju, T.S., Pang, H., Kurjanczyk, L.A., Penner, J.L., Moran, A.P. Eur. J. Biochem. (1993) [Pubmed]
  22. Structural studies on the core oligosaccharide of Phenylobacterium immobile strain K2 lipopolysaccharide. Chemical synthesis of 3-hydroxy-5c-dodecenoic acid. Bellmann, W., Lingens, F. Biol. Chem. Hoppe-Seyler (1985) [Pubmed]
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