Disease relevance of Equithesin

• It is concluded that, in the anesthetized animals prepared for acute recording, the decreased temperature of the brain during ischemia is a major factor in protecting neurons from damage, but that Equithesin anesthesia also has a significant protective effect [1].
• In the second experiment the same rats were anesthetized with 0.35 ml Chloropent/100 g b.w. and rectal temperature was systematically varied between 31 degrees C and 37 degrees C. Over the ranges of temperature and anesthetic employed, latencies increased more extensively with hypothermia than with anesthesia [2].

High impact information on Equithesin

• Field potential recordings were made, under chloropent anesthesia, from the stratum lucidum of CA3, with stimulation of either the mossy fiber or commissural/associational pathways, or in the DG granule-cell layer, with stimulation of the medial perforant pathway [3].
• We measured this stable concentration of K(+) (resting [K(+)](e)) for 3-5 min in different nuclei of the somatic projection to the lateral thalamus of controls and deafferented groups of adult rats under Equithesin anaesthesia [4].
• Anaesthesia with equithesin was found to prevent contralateral cell death [5].
• Evoked field potentials and extracellular unitary activity were recorded from entorhinal lateral and subicular ventral cortices under conditions of amygdala stimulation in equithesin-anesthetized rats [6].
• Under deep Chloropent anesthesia, a 0.5 X 1.0-mm square of fetal cortex or a 1.0-mm segment of fetal spinal cord was implanted subpially between the left dorsal column and the dorsal horn of 70 adult rats [7].

Biological context of Equithesin

• In an initial screen, the widely-used surgical anaesthetic, equithesin, was found to reduce core temperature, mean arterial blood pressure, and to increase the partial pressure of oxygen in arterial blood without producing any significant alteration in arterial pH or the partial pressure of carbon dioxide [8].
• In the first, chronically implanted rats were injected with either 0, 0.05, 0.10 or 0.20 ml Chloropent/100 g b.w., while body temperature was maintained [2].
• Hypothermia and chloropent anesthesia differentially affect the flash evoked potentials of hooded rats [2].
• 5. These results suggest that equithesin is a potential tool for hibernation research [9].

Anatomical context of Equithesin

• In addition, we found that the whole cerebral cortex reacts homogenously to CSD and that equithesin may reduce oxygen demand and energy production, which may have a protective effect on the brain exposed to pathophysiological conditions [10].
• Significant changes in neurotransmitters were observed in the caudate nucleus, nucleus accumbens, hippocampus and substantia nigra but not the frontal cortex upon exposure to isoflurane, an Equithesin-like mixture or carbon dioxide relative to control animals that were decapitated without anaesthesia [11].

Associations of Equithesin with other chemical compounds

• To investigate generalization between internal states, Sprague-Dawley rats were given either 0.835 ml/kg chloropent or 15 mg/kg sodium pentobarbital [12].

Analytical, diagnostic and therapeutic context of Equithesin

• Under Equithesin anaesthesia, one segment laminectomy was done over the T10-11 segments [13].
• In the 24 h-chicks, the saline and control groups showed a significant mean preference for the stuffed fowl, whilst the equithesin group did not [14].
• It is therefore recommended that equithesin should be further investigated with other functional modalities or behavioural tests prior to consider it as an anaesthetic agent for future functional MRI studies [15].

References