High impact information on TL-968

• The effects of the growth retardants 2'-isopropyl-4'-(trimethylammonium chloride)-5'-methylphenyl piperidine-1-carboxylate (AMO-1618) and calcium 3,5-dioxo-4-propionylcyclohexanecarboxylate (BX-112) on stem elongation were investigated in the rosette plant spinach (Spinacia oleracea L.) under long-day (LD) conditions [1].
• The effects of plant constituents on lipid metabolism were examined in swine that had been fed for 4 weeks a standard diet containing, in addition, (per kg diet) 3.15 g of the methanol serial solvent fraction garlic bulbs or 3.5 g of the petroleum ether solubles high-protein barley flour or 5 mg of the plant growth regulator, AMO 1618 [2].
• Assays of livers from rats fed 20 ppm AMO 1618 for 3 days had 24% less HMG-CoA reductase activity and 67% less cholesterol 7 alpha-hydroxylase activity than the controls [3].
• Since transcripts related to GA biosynthesis might be decreased in AMO-1618-treated cultures, a subtractive hybridization procedure was used to enrich cDNA fragments corresponding to messages that are more abundant in untreated than treated cultures [4].
• A fungal cDNA library was screened with the subtraction products and a clone was isolated that corresponds to two down-regulated transcripts in AMO-1618-treated cultures [4].

Biological context of TL-968

• The diterpene cyclization enzymes in extracts of uv-treated rice leaves show only a relatively modest inhibition by the plant growth retardants AMO-1618 and Phosfon D [5].
• Four-five days after plasmolysis or five days after AMO-1618 treatment antheridia which were at the stage of spermiogenesis had a lower level of DNA in manubria and revealed decreased productivity due to the smaller number of mitotic divisions in antheridial filaments [6].

Anatomical context of TL-968

• The inhibition of HMG-CoA reductase and the induction of FAS by AMO 1618 were tested in vitro, using 10--100 micrograms (28--280 mumoles) for 15 min with isolated hepatocytes from chicken and rat [3].

Associations of TL-968 with other chemical compounds

• The inhibitory effect of SSF-109 on cholesterol synthesis in isolated hepatocytes was studied using a radio-high-performance liquid chromatography system, and the results were compared with those of other inhibitors, triparanol and AMO-1618 [7].
• The sterol inhibitors miconazole, AMO 1618, CCC, and MER 29 increased both the incorporation of (14)C-IPP into artemisinin by cell-free extracts and the production of artemisinin in shoot cultures of ARTEMISIA ANNUA [8].
• The effects of diphenylamine, dimethyl sulfoxide, streptomycin, AMO-1618, and beta-ionone on the carotene composition of a wild-type and three mutant strains of Phycomyces blakesleeanus have been examined [9].

Gene context of TL-968

• After a 4 h exposure of cultures to AMO 1618 or TMD, followed by removal of the inhibitors, the utilization of [14C]acetate for synthesis of digitonin-precipitable sterols increased about twofold, an increase parallelled by the rise in HMG-CoA reductase [10].

References