Disease relevance of Dixyrazine

• The effects of prophylactic dixyrazine on postoperative vomiting after two different anaesthetic methods for squint surgery in children [1].
• Hair loss, depigmentation of hair, ichthyosis, and blepharoconjunctivitis produced by dixyrazine [2].
• One case (3.2%) of parkinsonism was noted as the only extrapyramidal reaction in the dixyrazine group [3].
• No difference was found between diazepam and dixyrazine, but they were both significantly superior to placebo in relieving anxiety, retching, and eructations [4].
• If the score was more than 30 mm at rest, the patients were given ketobemidone i.v. as treatment for postoperative pain, and dixyrazine i.v. against nausea and vomiting [5].

Psychiatry related information on Dixyrazine

• Clomipramine combined with dixyrazine seems superior to clomipramine in the treatment of panic disorder [6].
• A double-blind 12 week trial was undertaken to compare the effects of clomipramine + dixyrazine with clomipramine + placebo in the treatment of panic disorder with or without agoraphobia [6].

High impact information on Dixyrazine

• It is concluded that dixyrazine probably protects the blood-brain barrier during mechanical stress by modifying the endothelial cell membrane [7].
• A double blind study in out-patients with primary non-agitated depression treated with imipramine in combination with placebo, diazepam or dixyrazine [8].
• Dixyrazine for the prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy [9].
• CSF concentrations and clinical effects following intravenous dixyrazine premedication [10].
• The incidence of vomiting during the following 24 h was 65% in the control group, 48% in the droperidol group, and 25% in the dixyrazine group (P less than 0.05 as compared to the control group) [11].

Biological context of Dixyrazine

• Corresponding data for stimulation-induced increases in intestinal vascular resistance after dixyrazine were DA 156% and SA 28% [12].
• Pharmacokinetics of dixyrazine: low bioavailability, improved by food intake [13].

Associations of Dixyrazine with other chemical compounds

• In a prospective and randomized pilot study two antiemetic regimens comprising dixyrazine (240 mg) and metoclopramide (10 mg/kg) in high doses and given by continuous i.v. infusion were compared as means of preventing cisplatin-doxorubicin-induced nausead and vomiting [14].
• Specific gravity was significantly higher in all of the studied brain regions in rats given tirilazad or NBQX than in those given vehicle or dixyrazine (p < 0.001) [15].

Gene context of Dixyrazine

• The smallest dose of dixyrazine (12.5 mg) had no significant effect upon sleep pattern: the larger doses (25 mg and 50 mg) caused significant decreases in REM-sleep during the first nights of administration [16].
• Pretreatment with dixyrazine 10 mg/kg completely prevented the brain oedema and significantly reduced the albumin increase in CSF [17].

Analytical, diagnostic and therapeutic context of Dixyrazine

• Ninety patients scheduled for general or orthopaedic surgical procedures were randomly assigned to receive one of three i.m. premedications: dixyrazine 0.5 mg kg-1; morphine 0.15 mg kg-1 and scopolamine 0.0065 mg kg-1; or placebo [18].
• CONCLUSION: Prophylactic dixyrazine is an effective, safe, and cheap antiemetic drug for laparoscopic cholecystectomy without involving any significant adverse events [9].
• Premedication for gastroscopy. A comparative study of diazepam, dixyrazine, and placebo [4].
• METHODS: A total of 197 patients scheduled for laparoscopic cholecystectomy under general anesthesia were randomized to receive either dixyrazine 10 mg or placebo double-blinded at the end of surgery [9].
• Postoperative nausea and vomiting in children using patient-controlled analgesia: the effect of prophylactic intravenous dixyrazine [19].

References