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Chemical Compound Review

Dixyrazine     2-[2-[4-(2-methyl-3- phenothiazin-10-yl...

Synonyms: Esucos, Esucos (TN), SureCN184504, AG-E-74077, LS-66911, ...
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Disease relevance of Dixyrazine


Psychiatry related information on Dixyrazine


High impact information on Dixyrazine


Biological context of Dixyrazine


Associations of Dixyrazine with other chemical compounds

  • In a prospective and randomized pilot study two antiemetic regimens comprising dixyrazine (240 mg) and metoclopramide (10 mg/kg) in high doses and given by continuous i.v. infusion were compared as means of preventing cisplatin-doxorubicin-induced nausead and vomiting [14].
  • Specific gravity was significantly higher in all of the studied brain regions in rats given tirilazad or NBQX than in those given vehicle or dixyrazine (p < 0.001) [15].

Gene context of Dixyrazine

  • The smallest dose of dixyrazine (12.5 mg) had no significant effect upon sleep pattern: the larger doses (25 mg and 50 mg) caused significant decreases in REM-sleep during the first nights of administration [16].
  • Pretreatment with dixyrazine 10 mg/kg completely prevented the brain oedema and significantly reduced the albumin increase in CSF [17].

Analytical, diagnostic and therapeutic context of Dixyrazine


  1. The effects of prophylactic dixyrazine on postoperative vomiting after two different anaesthetic methods for squint surgery in children. Karlsson, E., Larsson, L.E., Nilsson, K. Acta anaesthesiologica Scandinavica. (1993) [Pubmed]
  2. Hair loss, depigmentation of hair, ichthyosis, and blepharoconjunctivitis produced by dixyrazine. Poulsen, J. Acta Derm. Venereol. (1981) [Pubmed]
  3. Betamethasone-dixyrazine versus metoclopramide as antiemetic treatment in cancer chemotherapy. Sorbe, B., Hallén, C. Acta oncologica (Stockholm, Sweden) (1988) [Pubmed]
  4. Premedication for gastroscopy. A comparative study of diazepam, dixyrazine, and placebo. Göransson, A.M. Scand. J. Gastroenterol. (1979) [Pubmed]
  5. Preoperative ropivacaine infiltration in breast surgery. Johansson, A., Axelson, J., Ingvar, C., Luttropp H-H, n.u.l.l., Lundberg, J. Acta anaesthesiologica Scandinavica. (2000) [Pubmed]
  6. Increased antipanic efficacy in combined treatment with clomipramine and dixyrazine. Feet, P.O., Götestam, K.G. Acta psychiatrica Scandinavica. (1994) [Pubmed]
  7. Phenothiazine-mediated protection of the blood-brain barrier during acute hypertension. Johansson, B.B., Auer, L.M., Linder, L.E. Stroke (1982) [Pubmed]
  8. A double blind study in out-patients with primary non-agitated depression treated with imipramine in combination with placebo, diazepam or dixyrazine. Feet, P.O., Larsen, S., Robak, O.H. Acta psychiatrica Scandinavica. (1985) [Pubmed]
  9. Dixyrazine for the prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy. Glaser, C., Sitzwohl, C., Wallner, T., Lerche, A., Marhofer, P., Schindler, I. Acta anaesthesiologica Scandinavica. (2004) [Pubmed]
  10. CSF concentrations and clinical effects following intravenous dixyrazine premedication. Oikkonen, M., Kärkelä, J., Seppälä, T. Eur. J. Clin. Pharmacol. (1995) [Pubmed]
  11. Postoperative emesis after pediatric strabismus surgery: the effect of dixyrazine compared to droperidol. Larsson, S., Jonmarker, C. Acta anaesthesiologica Scandinavica. (1990) [Pubmed]
  12. Influence of dixyrazine on intestinal and renal vasoconstrictor responses during fentanyl-nitrous oxide anaesthesia. Winsö, O., Biber, B., Holm, C., Martner, J. Acta anaesthesiologica Scandinavica. (1983) [Pubmed]
  13. Pharmacokinetics of dixyrazine: low bioavailability, improved by food intake. Liedholm, H., Lidén, A., Kroon, L., Melander, A., Wåhlin-Boll, E. Drug-nutrient interactions. (1985) [Pubmed]
  14. Betamethasone-dixyrazine versus betamethasone-metoclopramide as antiemetic treatment of cisplatin-doxorubicin-induced nausea in ovarian carcinoma patients. Sorbe, B., Hallén, C. Eur. J. Gynaecol. Oncol. (1991) [Pubmed]
  15. Pharmacological reduction of brain edema induced by intracarotid infusion of protamine sulphate: a comparison between a free radical scavenger and an AMPA receptor antagonist. Johansson, B.B., Westergren, I. Acta neurochirurgica. Supplementum. (1994) [Pubmed]
  16. Effects of dixyrazine and methaqualone on the sleep pattern in normal man. Risberg, A.M., Risberg, J., Elmqvist, D., Ingvar, D.H. Eur. J. Clin. Pharmacol. (1975) [Pubmed]
  17. Dixyrazine, a phenothiazine derivative, can prevent brain oedema induced by intracarotid injection of protamine sulphate. Westergren, I., Johansson, B.B. Acta neurochirurgica. (1991) [Pubmed]
  18. Premedication with intramuscular dixyrazine: (Esucos). A controlled double-blind comparison with morphine-scopolamine and placebo. Larsson, S., Hägerdal, M., Lundberg, D. Acta anaesthesiologica Scandinavica. (1988) [Pubmed]
  19. Postoperative nausea and vomiting in children using patient-controlled analgesia: the effect of prophylactic intravenous dixyrazine. Kokinsky, E., Thornberg, E., Nilsson, K., Larsson, L.E. Acta anaesthesiologica Scandinavica. (1999) [Pubmed]
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