Disease relevance of Strepcillin

• The treatment of endocarditis due to penicillin-susceptible streptococci with high-dose parenteral penicillin or a bactericidal penicillin substitute for four weeks or longer results in bacteriologic cure rates comparable with those achieved with combined penicillin-streptomycin regimens [1].
• Mechanism of penicillin-streptomycin synergy for clinical isolates of viridans streptococci [2].
• Effect of penicillin-streptomycin and other antibiotics on melanogenic parameters in cultured B16/F10 melanoma cells [3].
• The first experiment involved three antibiotic treatments: an unmedicated control diet, the diet plus 44 ppm of penicillin-streptomycin (1:3), and the diet plus 44 ppm of Zn bacitracin; each diet was fed in the presence and absence of a dried Bacillus subtilis culture to females 0 to 16 wk of age [4].
• Study of factors influencing the effectiveness of two treatments, penicillin-streptomycin and rifamycin, against experimentally induced staphylococcal mastitis in lactating cows [5].

High impact information on Strepcillin

• Routine exposure of Caco-2 cells to penicillin-streptomycin or gentamicin does not affect apical MRP2 functional activity in intestinal enterocytic Caco-2 cells [6].
• Caco-2 cells were grown in the presence or absence of either gentamicin or penicillin-streptomycin for up to 9 weeks [6].
• We conclude that insulin is essential for maximal steroidogenesis in a bovine luteal cell culture system, and that LH-stimulated progesterone production is inhibited in the presence of amphotericin-B, but is not inhibited by gentamicin or penicillin-streptomycin [7].
• Replacement of OF by penicillin streptomycin (PS) resulted in a significant decrease in mdr-1 mRNA expression, which was found to correlate with a decrease in the expression and functionality of the Pgp [8].
• After antibiotic starvation for 4 weeks, cells grown in antibiotic-free medium were then exposed to PS or OF; these cells showed an increase in mdr-1 mRNA/Pgp and MRP mRNA expression without a decrease in DNR cytotoxicity [8].

Chemical compound and disease context of Strepcillin

• Comparative capacity of orally administered amoxicillin and parenterally administered penicillin-streptomycin to protect rabbits against experimentally induced streptococcal endocarditis [9].

Biological context of Strepcillin

• During serial subcultures 50 micrograms per ml gentamicin and penicillin (100 U per ml)-streptomycin (100 micrograms per ml) depressed cell growth signficantly 2 weeks after the addition of the antibiotics; gentamicin, but not penicillin-streptomycin, stimulated cell growth before it became inhibitory [10].

Anatomical context of Strepcillin

• With this in mind, Plasmodium yoelii Py17X(NL) clone 1.1 sporozoites were incubated at 4, 24, or 37 C for 0, 8, or 24 hr in tissue culture medium M199 with 5% normal mouse serum and penicillin-streptomycin [11].
• Corneas were stored in M-K media with standard penicillin-streptomycin added and cultured up to 48 hours [12].
• The effectiveness of two antibiotic preparations, a combination of Penicillin-Streptomycin and Rifamycin SV, was measured on persistent subclinical infections produced experimentally by two strains of Staphylococus aureus in the bovine mammary gland [5].

Gene context of Strepcillin

• Homografts stored in Earle's Medium 199 enriched with 100 IU/mL Penicillin-Streptomycin for 2 to 28 days (mean 7.3+/-10.2 days) showed partially preserved cellular viability (MTT assay) and morphological integrity of the extracellular matrix (H-E staining) [13].

Analytical, diagnostic and therapeutic context of Strepcillin

• Twenty-five consecutive cultures of M-K media with a standard penicillin-streptomycin additive were performed at the time of keratoplasty [14].

References