Disease relevance of Melengestrol

• Total suppression of spontaneous endometrial carcinoma in BDII/Han rats by melengestrol acetate [1].
• Endometrial hyperplasia and mineralization in zoo felids treated with melengestrol acetate contraceptives [2].
• Pyometra and uterine adenocarcinoma in a melengestrol acetate-implanted captive coati (Nasua nasua) [3].
• Effect of dietary melengestrol acetate on the incidence of acute interstitial pneumonia in feedlot heifers [4].
• Effect of melengestrol acetate on development of 3-methylindole-induced pulmonary edema and emphysema in sheep [5].

High impact information on Melengestrol

• Melengestrol acetate, fed to hens on a balanced layer diet, caused reversible regression of follicles and, therefore, removal and return of support for the oviduct [6].
• Efficacy of either a single or split treatment of PGF2alpha after a 14 day melengestrol acetate treatment to synchronize estrus and induce luteolysis in Bos indicus x Bos taurus heifers [7].
• Methods to reduce or eliminate detection of estrus in a melengestrol acetate-PGF2alpha protocol for synchronization of estrus in beef heifers [8].
• Effects of melengestrol acetate on reproductive behavior and concentrations of LH and testosterone in bulls [9].
• Genital tract smooth muscle tumors are common in zoo felids but are not associated with melengestrol acetate contraceptive treatment [10].

Biological context of Melengestrol

• Reproductive response of yearling beef heifers to a melengestrol acetate-prostaglandin F2 alpha estrus synchronization system [11].
• These data characterize changes that occur among cows that are fed melengestrol acetate during the postpartum period and enhance observations from prior studies regarding MGA use [12].
• Improved synchrony of estrus and ovulation with the addition of GnRH to a melengestrol acetate-prostaglandin F2alpha synchronization treatment in beef heifers [13].
• The objective in the present experiment was to study the effects of melengestrol acetate (0.5 mg for 14 days starting at day 15 of the estrous cycle) on the cytophysiologic character of the bovine adenohypophysis [14].
• Estrus synchronization with melengestrol acetate in cyclic ewes. Insemination with fresh or frozen semen during the first or second estrus post treatment [15].

Anatomical context of Melengestrol

• Change in morphology of corpora lutea, central luteal cavities and steroid secretion patterns of postpartum suckled beef cows after melengestrol acetate with or without prostaglandin F(2alpha) [12].
• Melengestrol acetate alters muscle cell proliferation in heifers and steers [16].

Associations of Melengestrol with other chemical compounds

• Evaluation of a melengestrol acetate and prostaglandin F(2)alpha system for the synchronization of estrus in beef heifers [17].
• Synchronization of estrus with melengestrol acetate and prostaglandin F2 alpha in beef and dairy heifers [18].
• A 2 x 3 factorial experiment was conducted to determine the effects of an implant (trenbolene acetate/estradiol or no implant) and method of estrus suppression (immunization against GnRH, melengestrol acetate, or no suppression) on growth performance and carcass characteristics of heifers fed for slaughter [19].
• Estrus synchronization of beef cattle with a combination of melengestrol acetate and an injection of progesterone and 17beta-estradiol [20].
• Conception rate in Bos taurus and Bos indicus crossbred heifers after postweaning energy manipulation and synchronization of estrus with melengestrol acetate and fenprostalene [21].

Analytical, diagnostic and therapeutic context of Melengestrol

• Prolongation of rat heart allograft survival by a synthetic progestogen (melengestrol acetate) and ara-cytidine acylates [22].
• Determination of melengestrol acetate in bovine tissues by automated coupled-column normal-phase high-performance liquid chromatography [23].
• Immunosuppression with melengestrol [24].
• All cows were fed 4 mg/head/day of melengesterol acetate (an orally administered exogenous progestogen) through Days 3-30 and were bled by jugular venipuncture at 0600 and 0700 h on Day 5 for determination of 13,14-dihydro-15-keto-PGF2a (PGFM) [25].

References