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Chemical Compound Review

NSC-70897     2-amino-9-[3,4-dihydroxy-5...

Synonyms: Oprea1_459474, AC1L5INT, AC1Q6DXF, NSC70897, AR-1D8118, ...
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Disease relevance of N1-Methylguanosine

  • We show that one such feature may be the modified nucleoside 1-methylguanosine (m(1)G37), which prevents frameshifting and is present adjacent to and 3' of the anticodon (position 37) in the same subset of tRNAs from all organisms, including that with the smallest sequenced genome (Mycoplasma genitalium), and organelles [1].
  • Structural requirements for the formation of 1-methylguanosine in vivo in tRNA(Pro)GGG of Salmonella typhimurium [2].
  • The second gene encodes a 21,000 Mr polypeptide of unknown function and the third gene (trmD) encodes the enzyme tRNA(m1G37)methyltransferase, which catalyzes the formation of 1-methylguanosine (m1G) next to the 3' end of the anticodon (position 37) of some tRNAs in Escherichia coli [3].
  • We now report the shifty tRNA(Phe) contains 1-methylguanosine (m(1)G) in place of Y and that the m(1)G form from rabbit reticulocytes stimulates frameshifting more efficiently than its m(1)G-containing counterpart from mouse neuroblastoma cells [4].
  • No significant differences in the concentrations of pseudouridine, 1-methylguanosine, N2-methylguanosine or N2,N2-dimethylguanosine were observed in pre- and post-operative urines from patients with colorectal cancer and normal urines [5].

High impact information on N1-Methylguanosine


Chemical compound and disease context of N1-Methylguanosine


Associations of N1-Methylguanosine with other chemical compounds


Gene context of N1-Methylguanosine

  • IgM antiguanosine antibodies in normal sera were polyspecific and bound other nucleosides and 1-methylguanosine but not denatured DNA (ssDNA) [13].
  • In contrast, IgG antiguanosine antibodies from the SLE patients bound guanosine and ssDNA but not other nucleosides or 1-methylguanosine [13].


  1. A primordial tRNA modification required for the evolution of life? Björk, G.R., Jacobsson, K., Nilsson, K., Johansson, M.J., Byström, A.S., Persson, O.P. EMBO J. (2001) [Pubmed]
  2. Structural requirements for the formation of 1-methylguanosine in vivo in tRNA(Pro)GGG of Salmonella typhimurium. Qian, Q., Björk, G.R. J. Mol. Biol. (1997) [Pubmed]
  3. Differentially expressed trmD ribosomal protein operon of Escherichia coli is transcribed as a single polycistronic mRNA species. Byström, A.S., von Gabain, A., Björk, G.R. J. Mol. Biol. (1989) [Pubmed]
  4. 1-Methylguanosine in place of Y base at position 37 in phenylalanine tRNA is responsible for its shiftiness in retroviral ribosomal frameshifting. Carlson, B.A., Mushinski, J.F., Henderson, D.W., Kwon, S.Y., Crain, P.F., Lee, B.J., Hatfield, D.L. Virology (2001) [Pubmed]
  5. Reversed-phase liquid chromatographic investigation of nucleosides and bases in mucosa and modified nucleosides in urines from patients with gastrointestinal cancer. Nakano, K., Shindo, K., Yasaka, T., Yamamoto, H. J. Chromatogr. (1985) [Pubmed]
  6. Prevention of translational frameshifting by the modified nucleoside 1-methylguanosine. Björk, G.R., Wikström, P.M., Byström, A.S. Science (1989) [Pubmed]
  7. Enzymatic conversion of guanosine 3' adjacent to the anticodon of yeast tRNAPhe to N1-methylguanosine and the wye nucleoside: dependence on the anticodon sequence. Droogmans, L., Grosjean, H. EMBO J. (1987) [Pubmed]
  8. Deficiency of 1-methylguanosine in tRNA from Salmonella typhimurium induces frameshifting by quadruplet translocation. Hagervall, T.G., Tuohy, T.M., Atkins, J.F., Björk, G.R. J. Mol. Biol. (1993) [Pubmed]
  9. Normal and modified urinary nucleosides represent novel biomarkers for colorectal cancer diagnosis and surgery monitoring. Feng, B., Zheng, M.H., Zheng, Y.F., Lu, A.G., Li, J.W., Wang, M.L., Ma, J.J., Xu, G.W., Liu, B.Y., Zhu, Z.G. J. Gastroenterol. Hepatol. (2005) [Pubmed]
  10. Role of modified nucleosides of yeast tRNA(Phe) in ribosomal binding. Ashraf, S.S., Guenther, R.H., Ansari, G., Malkiewicz, A., Sochacka, E., Agris, P.F. Cell Biochem. Biophys. (2000) [Pubmed]
  11. Purification and partial characterization of purine nucleoside phosphorylase from Serratia marcescens. Choi, H.S. Biosci. Biotechnol. Biochem. (1998) [Pubmed]
  12. Study of nucleic acid metabolism in two astronauts. Szabo, L.D., Keresztes, P., Pallos, J.P., Csato, E., Predmerszky, T. Advances in space research : the official journal of the Committee on Space Research (COSPAR). (1984) [Pubmed]
  13. The fine specificity of IgG antiguanosine antibodies in systemic lupus erythematosus. Yee, W.S., Weisbart, R.H. Clin. Immunol. Immunopathol. (1985) [Pubmed]
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