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Chemical Compound Review

CHEMBL164852     N-ethyl-N-methyl-nitrous amide

Synonyms: CCRIS 3058, AG-K-49606, HSDB 5109, LS-7598, KB-58696, ...
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Disease relevance of N-ethyl-N-methyl-nitrous amide


High impact information on N-ethyl-N-methyl-nitrous amide


Biological context of N-ethyl-N-methyl-nitrous amide


Anatomical context of N-ethyl-N-methyl-nitrous amide


Associations of N-ethyl-N-methyl-nitrous amide with other chemical compounds


Gene context of N-ethyl-N-methyl-nitrous amide

  • P-450ac also catalyzed the oxygenation of N-nitrosomethylethylamine and aniline and the activity was enhanced slightly by cytochrome b5 [12].
  • P450ac was also active in the metabolism of N-nitrosoethylmethylamine (NEMA), but was less active than phenobarbital-inducible cytochrome P450 (P450b) in the metabolism of N-nitrosobutylmethylamine (NBMA), especially in catalysing the debutylation reaction [13].


  1. Extent of DNA 2-hydroxyethylation by N-nitrosomethylethylamine and N-nitrosodiethylamine in vivo. von Hofe, E., Kleihues, P., Keefer, L.K. Carcinogenesis (1986) [Pubmed]
  2. Methylation versus ethylation of DNA in target and nontarget tissues of Fischer 344 rats treated with N-nitrosomethylethylamine. von Hofe, E., Grahmann, F., Keefer, L.K., Lijinsky, W., Nelson, V., Kleihues, P. Cancer Res. (1986) [Pubmed]
  3. A new assay for the microsomal metabolism of nitrosamines. Farrelly, J.G. Cancer Res. (1980) [Pubmed]
  4. Beta-deuteration of N-nitrosoethylmethylamine causes a shift in DNA methylation from rat liver to esophagus. von Hofe, E., Schmerold, I., Nims, R.W., Keefer, L.K., Reist, E.J., Kleihues, P. Carcinogenesis (1991) [Pubmed]
  5. Single-dose toxicokinetics of N-nitrosomethylethylamine and N-nitrosomethyl (2,2,2-trideuterioethyl)amine in the rat. Streeter, A.J., Nims, R.W., Anderson, L.M., Heur, Y.H., von Hofe, E., Kleihues, P., Nelson, V.C., Mico, B.A., Keefer, L.K. Arch. Toxicol. (1990) [Pubmed]
  6. Metabolism of chemical carcinogens by cultured human and rat bladder epithelial cells. Autrup, H., Grafstrom, R.C., Christensen, B., Kieler, J. Carcinogenesis (1981) [Pubmed]
  7. Activation of nitrosamines and other carcinogens by mouse-liver S9, mouse hepatocytes and in the host-mediated assay produces different mutagenic responses in Salmonella TA1535. Kerklaan, P., Bouter, S., Mohn, G. Mutat. Res. (1983) [Pubmed]
  8. DNA methylation in rat tissues by a series of homologous aliphatic nitrosamines ranging from N-nitrosodimethylamine to N-nitrosomethyldodecylamine. von Hofe, E., Schmerold, I., Lijinsky, W., Jeltsch, W., Kleihues, P. Carcinogenesis (1987) [Pubmed]
  9. N-nitrosamines and their effects on the level of glutathione, glutathione reductase and glutathione S-transferase activities in the liver of male mice. Sheweita, S.A., Mostafa, M.H. Cancer Lett. (1996) [Pubmed]
  10. Detection of metabolites of N-nitrosopyrrolidine and N-nitrosoethylmethylamine in cultures of human bladder epithelial cells of normal origin. Nebelin, E., Autrup, H., Christensen, B., Blomkvist, G. IARC Sci. Publ. (1982) [Pubmed]
  11. Interaction of the tobacco-specific nitrosamines, methylethylnitrosamine and N-nitrosonornicotine, with DNA and guanosine. Lai, D.Y., Arcos, J.C., Argus, M.F. Res. Commun. Chem. Pathol. Pharmacol. (1980) [Pubmed]
  12. Acetone-inducible cytochrome P-450: purification, catalytic activity, and interaction with cytochrome b5. Patten, C.J., Ning, S.M., Lu, A.Y., Yang, C.S. Arch. Biochem. Biophys. (1986) [Pubmed]
  13. Enzymatic mechanisms in the metabolic activation of N-nitrosodialkylamines. Yang, C.S., Patten, C., Lee, M.J., Li, M., Yoo, J.S., Pan, J., Hong, J. IARC Sci. Publ. (1987) [Pubmed]
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