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Chemical Compound Review

ROSE BENGAL     dipotassium2,3,4,5- tetrachloro-6-(2,4,5,7...

Synonyms: Rose bengale, Bengal rose, CHEMBL594741, CCRIS 9135, CHEBI:52261, ...
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Disease relevance of ROSE BENGAL

  • We show that RB followed by AGID-NH is a simple and effective system for diagnosing sheep brucellosis [1].
  • Competitive and standard enzyme-linked immunosorbent assays (ELISAs), rose bengal (RB), complement fixation, and agar gel immunoprecipitation with native hapten (AGID-NH) were compared by using sera from Brucella-free, Brucella melitensis-infected, and B. melitensis Rev1-vaccinated sheep [1].
  • (1) An increase in the amount of Rose Bengale adsorbed on the gill of fish was followed by the increase in red corpuscle number, and it was assumed that the death of fish in xanthene dye solution was due to anoxemia [2].
  • In the present study tear secretion was studied in 20 consecutive dry eye patients [40 eyes; Schirmer test after topical anesthesia < 5.5 mm/5 min; at least moderate squamous metaplasia of the conjunctival epithelium; bengal rose staining (Bijsterveld score > 4); severe dry eye complaints] [3].
  • The ferning method has a sensitivity and a specificity of the same order as the commonly used tests for Sjögren's syndrome (Schirmer I, BUT, rose bengale, lactoferrin) [4].

High impact information on ROSE BENGAL

  • Using the voltage-clamp technique to identify the mechanism underlying the ROS-measured effects, we found that RB induced a large increase in the oocyte membrane conductance (G(m)) [5].
  • The rate constants were calculated directly from 1O2 phosphorescence lifetimes observed after laser pulse excitation of rose bengal (RB), used to generate 1O2 [6].
  • Samples were evaluated for motility and sperm populations by computer-aided semen analysis (CASA), plasma membrane integrity (carboxy-fluorescein diacetate and propidium iodide), and sperm morphology (Bengal Rose) [7].
  • METHODS: Three different groups of subjects were enrolled: one group of dry eyes with nonsignificant signs of epithelial disease (n = 12), the second group of dry eye positive with 1% Bengal rose staining of the cornea and of the conjunctiva (n = 18), and a third of normal eyes as control group (n = 15) [8].
  • The effect of 3,4,5,6-tetrachloro-2',4',5',7'-tetraiodo-fluorescein sodium salt (Rose Bengal B or FD&C Red No. 105, molecular weight 1017.6) on the thyroid of rats treated with N-bis(2-hydroxypropyl)-nitrosamine (DHPN) and iodine-deficient (I-def) diet is studied [9].

Chemical compound and disease context of ROSE BENGAL

  • Methylene blue and rose bengale showed strong acute toxicity to fish and it was assumed that high affinity of these dyes to gill was responsible to depressing the function of gill, to make fish suffer from anoxemia and die [10].

Biological context of ROSE BENGAL

  • By photoirradiation of enzyme-phenylalanine complex in the presence of rose bengale, a significant amount of amino acid was bound to the alpha subunit (Mr = 73 000) of phenylalanyl-tRNA synthetase, confirming that the amino acid binding site is located on this subunit, as previously suggested by modification of thiol groups [11].

Associations of ROSE BENGAL with other chemical compounds


Analytical, diagnostic and therapeutic context of ROSE BENGAL

  • The most sensitive tests were indirect ELISA and RB, and the most specific tests were AGID-NH and competitive ELISA [1].


  1. Performance of competitive and indirect enzyme-linked immunosorbent assays, gel immunoprecipitation with native hapten polysaccharide, and standard serological tests in diagnosis of sheep brucellosis. Marín, C.M., Moreno, E., Moriyón, I., Díaz, R., Blasco, J.M. Clin. Diagn. Lab. Immunol. (1999) [Pubmed]
  2. Studies on the toxicity of coal-tar dyes II. Examination of the biological reaction of coal-tar dyes to vital body. Tonogai, Y., Ito, Y., Iwaida, M., Tati, M., Ose, Y., Sato, T. The Journal of toxicological sciences. (1979) [Pubmed]
  3. Tear secretion in dry eyes as assessed by objective fluorophotometry. Göbbels, M., Goebels, G., Breitbach, R., Spitznas, M. German journal of ophthalmology. (1992) [Pubmed]
  4. Quantitative tear ferning. Clinical investigations. Norn, M. Acta ophthalmologica. (1994) [Pubmed]
  5. Effect of reactive oxygen species on NH4+ permeation in Xenopus laevis oocytes. Cougnon, M., Benammou, S., Brouillard, F., Hulin, P., Planelles, G. Am. J. Physiol., Cell Physiol. (2002) [Pubmed]
  6. Quenching of singlet molecular oxygen (1O2) by azide anion in solvent mixtures. Li, M.Y., Cline, C.S., Koker, E.B., Carmichael, H.H., Chignell, C.F., Bilski, P. Photochem. Photobiol. (2001) [Pubmed]
  7. Prognostic value of canine frozen-thawed semen parameters on in vitro sperm-oocyte interactions. Silva, A.R., Cardoso, R.d.e. .C., Silva, L.D., Chirinéa, V.H., Lopes, M.D., Souza, F.F. Theriogenology (2006) [Pubmed]
  8. Low spatial-contrast sensitivity in dry eyes. Rolando, M., Iester, M., Macrí, A., Calabria, G. Cornea (1998) [Pubmed]
  9. FD&C Red No. 105 (Rose Bengal B) neutralizes the thyroid tumor promoting effect of iodine-deficient diet in rats. Kanno, J., Goda, Y., Sato, K., Yoshihira, K., Hayashi, Y. Toxicology (1995) [Pubmed]
  10. Actual survey on TLm (median tolerance limit) values of environmental pollutants, especially on amines, nitriles, aromatic nitrogen compounds and artificial dyes. Tonogai, Y., Ogawa, S., Ito, Y., Iwaida, M. The Journal of toxicological sciences. (1982) [Pubmed]
  11. Yeast phenylalanyl-tRNA synthetase. Properties of the histidyl residues. Raffin, J.P., Remy, P. Biochim. Biophys. Acta (1978) [Pubmed]
  12. Tubifex tubifex Müll.--photosensitive organism. Vytlacilová, J., Chobot, V., Jahodár, L., Laakso, I., Vuorela, P. Cent. Eur. J. Public Health (2004) [Pubmed]
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