The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

AG-A-33863     2-(aminocarbonylamino) butanedioic acid

Synonyms: CHEMBL1161506, ACMC-209rfe, CHEBI:64850, ANW-39816, NSC-14983, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of NSC14983

 

High impact information on NSC14983

 

Biological context of NSC14983

 

Anatomical context of NSC14983

  • We find that rtg2 Delta cells take up USA even without the presence of [URE3] [4].
  • Carbamyl-aspartate appears not to be degraded rapidly in mammalian cells but it can pass into the blood and could possible disrupt brain metabolism by action as an acetylaspartate analog, if it passes the blood-brain barrier [9].
  • In the present study, infusion of carbamyl-DL-aspartic acid (CAA) into rats was used to demonstrate the role of the endogenous hormones of the hypothalamus-parotid gland endocrine axis in stimulating IDDP, as observed by fluorescence microscopy of longitudinal sections of molar teeth [10].
 

Associations of NSC14983 with other chemical compounds

 

Gene context of NSC14983

  • The Saccharomyces cerevisiae allantoate/ureidosuccinate permease gene (DAL5) is often used as a reporter in studies of the Tor1/2 protein kinases which are specifically inhibited by the clinically important immunosuppressant and anti-neoplastic drug, rapamycin [14].
 

Analytical, diagnostic and therapeutic context of NSC14983

References

  1. Homotropic effects in aspartate transcarbamoylase. What happens when the enzyme binds a single molecule of the bisubstrate analog N-phosphonacetyl-L-aspartate? Foote, J., Schachman, H.K. J. Mol. Biol. (1985) [Pubmed]
  2. Antibacterial and antitumor activity of some derivatives of ureidosuccinic acid. Golovinsky, E.V., Maneva, L.S., Angelov, I.I., Veljanova, K.D., Sniker, D.J., Stankevich, E.K. Neoplasma (1976) [Pubmed]
  3. Complete sequence of a eukaryotic regulatory gene. Hubert, J.C., Guyonvarch, A., Kammerer, B., Exinger, F., Liljelund, P., Lacroute, F. EMBO J. (1983) [Pubmed]
  4. A novel Rtg2p activity regulates nitrogen catabolism in yeast. Pierce, M.M., Maddelein, M.L., Roberts, B.T., Wickner, R.B. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  5. T-state inhibitors of E. coli aspartate transcarbamoylase that prevent the allosteric transition. Heng, S., Stieglitz, K.A., Eldo, J., Xia, J., Cardia, J.P., Kantrowitz, E.R. Biochemistry (2006) [Pubmed]
  6. Mks1p is a regulator of nitrogen catabolism upstream of Ure2p in Saccharomyces cerevisiae. Edskes, H.K., Hanover, J.A., Wickner, R.B. Genetics (1999) [Pubmed]
  7. Pyrimidine biosynthesis in parasitic protozoa: purification of a monofunctional dihydroorotase from Plasmodium berghei and Crithidia fasciculata. Krungkrai, J., Cerami, A., Henderson, G.B. Biochemistry (1990) [Pubmed]
  8. Correlation between restriction map, genetic map and catalytic functions in the gene complex URA2. Potier, S., Souciet, J.L., Lacroute, F. Mol. Gen. Genet. (1987) [Pubmed]
  9. The genes for and regulation of the enzyme activities of two multifunctional proteins required for the de novo pathway for UMP biosynthesis in mammals. Jones, M.E. Molecular biology, biochemistry, and biophysics. (1980) [Pubmed]
  10. Further evidence for a hypothalamus-parotid gland endocrine axis in the rat. Leonora, J., Tieche, J.M., Steinman, R.R. Arch. Oral Biol. (1993) [Pubmed]
  11. Effect of infusing selected chemical compounds on dentinal fluid movement in the rat. Steinman, R.R., Leonora, J. J. Dent. Res. (1975) [Pubmed]
  12. Expression, purification, crystallization and preliminary X-ray crystallographic studies of a cold-adapted aspartate carbamoyltransferase from Moritella profunda. De Vos, D., Hulpiau, P., Vergauwen, B., Savvides, S.N., Van Beeumen, J. Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun. (2005) [Pubmed]
  13. Harnessing natural diversity to probe metabolic pathways. Homann, O.R., Cai, H., Becker, J.M., Lindquist, S.L. PLoS Genet. (2005) [Pubmed]
  14. Synergistic operation of four cis-acting elements mediate high level DAL5 transcription in Saccharomyces cerevisiae. Rai, R., Daugherty, J.R., Tate, J.J., Buford, T.D., Cooper, T.G. FEMS Yeast Res. (2004) [Pubmed]
  15. Aspartate transcarbamylase of Escherichia coli. Heterogeneity of binding sites for carbamyl phosphate and fluorinated analogs of carbamyl phosphate. Ridge, J.A., Roberts, F., Schaffer, M.H., Stark, G.R. J. Biol. Chem. (1976) [Pubmed]
 
WikiGenes - Universities