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Chemical Compound Review

KB-47177     [(2-methyl-2-methylsulfanyl...

Synonyms: ZINC01532114, AC1NS45Q, 116-06-3, 52671-EP2270010A1, 52671-EP2277867A2, ...
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Disease relevance of aldicarb


Psychiatry related information on aldicarb


High impact information on aldicarb


Chemical compound and disease context of aldicarb

  • A patient with carbamyl phosphate synthetase deficiency had four episodes of hyperammonemia, up to 226 microM, associated with valproate (VPA) treatment [12].
  • Escherichia coli carbamyl-phosphate synthetase (CPSase), a monofunctional protein consisting of amido-transferase and synthetase subunits, is allosterically inhibited by UMP and activated by NH3, IMP, and ornithine [5].
  • Application of the pulse-chase procedure to study of the binding and utilization of ATP by glutamine-dependent carbamyl phosphate synthetase from Escherichia coli showed that the enzyme binds the two molecules of ATP used in this reaction at the same time, and that the two ATP-binding sites are functionally different [13].
  • The amidotransferase or glutaminase (GLNase) domain of mammalian carbamyl phosphate synthetase (CPSase), part of a 243-kDa polypeptide that initiates de novo pyrimidine biosynthesis, has been cloned and expressed in Escherichia coli [14].
  • Carbamyl phosphate synthetase from Escherichia coli has been shown to use only the A isomer of adenosine-5'-[2-thiotriphosphate] in both the ATPase reaction (MgATP HCO3- leads to MgADP + Pi) and the carbamyl phosphate synthesis reaction (2MgATP + HCO3- + L-glutamine leads to 2MgADP + Pi + carbamyl-P + L-glutamate) [15].

Biological context of aldicarb

  • We have identified an essential cis element in the proximal promoter region of the rat carbamyl phosphate synthetase I (CPSI) gene that is requisite for promoter activity in liver nuclear extracts [16].
  • Mitochondrial ultrastructure was also essentially normal in the heterozygotes for carbamyl phosphate synthetase I deficiency [17].
  • In parabiotic animals, carbamyl phosphate synthetase activity and urea synthesis were lowered in the host livers of partners bearing tumors with high carbamyl phosphate synthetase- and urea-synthetic activity, but there was no significant effect on urea cycle activity in the normal partners [18].
  • Sequence of the small subunit of yeast carbamyl phosphate synthetase and identification of its catalytic domain [19].
  • The amidotransferase or glutaminase domain (GLN domain) of mammalian carbamyl-phosphate synthetase II (CPSase II) catalyzes glutamine hydrolysis and transfers ammonia to the synthetase domain (CPS domain), where carbamyl phosphate formation is catalyzed in three consecutive reactions [20].

Anatomical context of aldicarb


Associations of aldicarb with other chemical compounds


Gene context of aldicarb

  • Arginine deprivation imposed by PALO also caused increased expression of CPA1 and CPA2, coding respectively for the small and large subunits of arginine-specific carbamyl-phosphate synthetase [29].
  • The protein sequence data provide strong evidence that the carbamyl phosphate synthetase I gene of rat, the carAB gene of E. coli, and the CPA1 and CPA2 genes of yeast were derived from common ancestral genes [30].
  • Proteolytically induced changes in the molecular form of the carbamyl phosphate synthetase-uracil-aspartate transcarbamylase complex coded for by the URA2 locus in Saccharomyces cerevisiae [31].
  • The cDNA insert contained all of the coding region for the glutaminase (GLN) and carbamyl phosphate synthetase (CPS) domains but lacked a short amino-terminal segment [32].
  • A construct was made in which the intergenic region between the contiguous carA and carB genes was deleted and the sequences encoding the carbamyl-phosphate synthetase subunits were fused in frame [33].

Analytical, diagnostic and therapeutic context of aldicarb


  1. Transiently reduced activity of carbamyl phosphate synthetase and ornithine transcarbamylase in liver of children with Reye's syndrome. Brown, T., Hug, G., Lansky, L., Bove, K., Scheve, A., Ryan, M., Brown, H., Schubert, W.K., Partin, J.C., Lloyd-Still, J. N. Engl. J. Med. (1976) [Pubmed]
  2. Treatment of episodic hyperammonemia in children with inborn errors of urea synthesis. Brusilow, S.W., Danney, M., Waber, L.J., Batshaw, M., Burton, B., Levitsky, L., Roth, K., McKeethren, C., Ward, J. N. Engl. J. Med. (1984) [Pubmed]
  3. Differences in total mitochondrial proteins and proteins synthesized by mitochondria from rat liver and Morris hepatomas 9618A, 5123C, and 5123tc. Irwin, C.C., Malkin, L.I., Morris, H.P. Cancer Res. (1978) [Pubmed]
  4. Carbamyl phosphate synthetases in rat liver neoplasms. Lawson, D., Paik, W.K., Morris, H.P., Weinhouse, S. Cancer Res. (1975) [Pubmed]
  5. Identification of the regulatory domain of the mammalian multifunctional protein CAD by the construction of an Escherichia coli hamster hybrid carbamyl-phosphate synthetase. Liu, X., Guy, H.I., Evans, D.R. J. Biol. Chem. (1994) [Pubmed]
  6. Purification and properties of porcine liver ornithine transcarbamylase. Koger, J.B., Howell, R.G., Kelly, M., Jones, E.E. Arch. Biochem. Biophys. (1994) [Pubmed]
  7. Carbamyl phosphate synthetase I deficiency. One base substitution in an exon of the CPS I gene causes a 9-basepair deletion due to aberrant splicing. Hoshide, R., Matsuura, T., Haraguchi, Y., Endo, F., Yoshinaga, M., Matsuda, I. J. Clin. Invest. (1993) [Pubmed]
  8. Arginine, an indispensable amino acid for patients with inborn errors of urea synthesis. Brusilow, S.W. J. Clin. Invest. (1984) [Pubmed]
  9. Phosphorylation and activation of hamster carbamyl phosphate synthetase II by cAMP-dependent protein kinase. A novel mechanism for regulation of pyrimidine nucleotide biosynthesis. Carrey, E.A., Campbell, D.G., Hardie, D.G. EMBO J. (1985) [Pubmed]
  10. Cell-free translation and thyroxine induction of carbamyl phosphate synthetase I messenger RNA in tadpole liver. Mori, M., Morris, S.M., Cohen, P.P. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  11. Functional arginyl residues as ATP binding sites of glutamine synthetase and carbamyl phosphate synthetase. Powers, S.G., Riordan, J.F. Proc. Natl. Acad. Sci. U.S.A. (1975) [Pubmed]
  12. Valproate-induced hyperammonemia. Batshaw, M.L., Brusilow, S.W. Ann. Neurol. (1982) [Pubmed]
  13. Mechanism of the reaction catalyzed by carbamyl phosphate synthetase. Binding of ATP to the two functionally different ATP sites. Powers, S.G., Meister, A. J. Biol. Chem. (1978) [Pubmed]
  14. Cloning, expression, and functional interactions of the amidotransferase domain of mammalian CAD carbamyl phosphate synthetase. Guy, H.I., Evans, D.R. J. Biol. Chem. (1994) [Pubmed]
  15. Carbamyl phosphate synthetase of Escherichia coli uses the same diastereomer of adenosine-5'-[2-thiotriphosphate] at both ATP sites. Raushel, F.M., Anderson, P.M., Villafranca, J.J. J. Biol. Chem. (1978) [Pubmed]
  16. Activity of the carbamyl phosphate synthetase I promoter in liver nuclear extracts is dependent on a cis-acting C/EBP recognition element. Howell, B.W., Lagacé, M., Shore, G.C. Mol. Cell. Biol. (1989) [Pubmed]
  17. Liver ultrastructure in mitochondrial urea cycle enzyme deficiencies and comparison with Reye's syndrome. Latham, P.S., LaBrecque, D.R., McReynolds, J.W., Klatskin, G. Hepatology (1984) [Pubmed]
  18. Urea synthesis in Novikoff and Morris hepatomas. Lawson, D., Paik, W.K., Morris, H.P., Weinhouse, S. Cancer Res. (1977) [Pubmed]
  19. Sequence of the small subunit of yeast carbamyl phosphate synthetase and identification of its catalytic domain. Nyunoya, H., Lusty, C.J. J. Biol. Chem. (1984) [Pubmed]
  20. Trapping an activated conformation of mammalian carbamyl-phosphate synthetase. Guy, H.I., Evans, D.R. J. Biol. Chem. (1997) [Pubmed]
  21. Rat carbamyl-phosphate synthetase I gene. Promoter sequence and tissue-specific transcriptional regulation in vitro. Lagacé, M., Howell, B.W., Burak, R., Lusty, C.J., Shore, G.C. J. Biol. Chem. (1987) [Pubmed]
  22. In vitro synthesis of a putative precursor to the mitochondrial enzyme, carbamyl phosphate synthetase. Shore, G.C., Carignan, P., Raymond, Y. J. Biol. Chem. (1979) [Pubmed]
  23. Wortmannin inhibits insulin secretion in pancreatic islets and beta-TC3 cells independent of its inhibition of phosphatidylinositol 3-kinase. Gao, Z., Konrad, R.J., Collins, H., Matschinsky, F.M., Rothenberg, P.L., Wolf, B.A. Diabetes (1996) [Pubmed]
  24. Molecular cloning of cDNA for rat and human carbamyl phosphate synthetase I. Adcock, M.W., O'Brien, W.E. J. Biol. Chem. (1984) [Pubmed]
  25. Orthotopic liver transplantation for urea cycle enzyme deficiency. Todo, S., Starzl, T.E., Tzakis, A., Benkov, K.J., Kalousek, F., Saheki, T., Tanikawa, K., Fenton, W.A. Hepatology (1992) [Pubmed]
  26. Collateral sensitivity to N-(phosphonacetyl)-L-aspartic acid in a line of P388 leukemia cells selected for resistance to L-(alpha S, 5S)-alpha-amino-3- chloro-4,5-dihydro-5-isoxazoleacetic acid (acivicin). Ardalan, B., Jayaram, H.N., Johnson, R.K. Cancer Res. (1983) [Pubmed]
  27. Evidence for an exceptionally reactive arginyl residue at the binding site for carbamyl phosphate in bovine ornithine transcarbamylase. Marshall, M., Cohen, P.P. J. Biol. Chem. (1980) [Pubmed]
  28. Immunochemical analysis of the domain structure of CAD, the multifunctional protein that initiates pyrimidine biosynthesis in mammalian cells. Grayson, D.R., Lee, L., Evans, D.R. J. Biol. Chem. (1985) [Pubmed]
  29. Arginine restriction induced by delta-N-(phosphonacetyl)-L-ornithine signals increased expression of HIS3, TRP5, CPA1, and CPA2 in Saccharomyces cerevisiae. Kinney, D.M., Lusty, C.J. Mol. Cell. Biol. (1989) [Pubmed]
  30. Characterization and derivation of the gene coding for mitochondrial carbamyl phosphate synthetase I of rat. Nyunoya, H., Broglie, K.E., Widgren, E.E., Lusty, C.J. J. Biol. Chem. (1985) [Pubmed]
  31. Proteolytically induced changes in the molecular form of the carbamyl phosphate synthetase-uracil-aspartate transcarbamylase complex coded for by the URA2 locus in Saccharomyces cerevisiae. Denis-Duphil, M., Mathien-Shire, Y., Hervé, G. J. Bacteriol. (1981) [Pubmed]
  32. Mammalian carbamyl phosphate synthetase (CPS). DNA sequence and evolution of the CPS domain of the Syrian hamster multifunctional protein CAD. Simmer, J.P., Kelly, R.E., Rinker, A.G., Scully, J.L., Evans, D.R. J. Biol. Chem. (1990) [Pubmed]
  33. Activation by fusion of the glutaminase and synthetase subunits of Escherichia coli carbamyl-phosphate synthetase. Guy, H.I., Rotgeri, A., Evans, D.R. J. Biol. Chem. (1997) [Pubmed]
  34. A major polypeptide component of rat liver mitochondria: carbamyl phosphate synthetase. Clarke, S. J. Biol. Chem. (1976) [Pubmed]
  35. Regulation and expression of carbamyl phosphate synthetase I mRNA in developing rat liver and Morris hepatoma 5123D. Ryall, J., Rachubinski, R.A., Nguyen, M., Rozen, R., Broglie, K.E., Shore, G.C. J. Biol. Chem. (1984) [Pubmed]
  36. Bone accumulation of the Tc-99m complex of carbamyl phosphate and its analogs. Hosain, P., Spencer, R.P., Ahlquist, K.J., Sripada, P.K. J. Nucl. Med. (1978) [Pubmed]
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