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Chemical Compound Review:

SureCN8624463 (2-phenoxyphenyl)methyl 2,2-dimethyl-3-(2...

Synonyms: AC1MHL2B

Chosidow, O. et al., Petersen, J.L. et al., Yamada, T. et al., Yang, Y.C. et al., Russell, R.C. et al., et al.

Yamada, Ueda, Yoshioka, Kawamura, Seki, Okuno, Mikami,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of S-2539-F

Neither d-phenothrin nor pyrethrum exhibited fumigant toxicity [1].

High impact information on S-2539-F

Ovicidal and pediculicidal activities of 0.5% malathion and 0.3% d-phenothrin lotions were tested in an experimental model of P humanus capitis grown on rabbits to ensure that the two treatments were pharmacologically equipotent [2].
Salicylaldehyde was nine and eight times more active than pyrethrum and d-phenothrin, respectively [1].
We have developed protocols to deliver 2% d-phenothrin at a dose of 35 g per 100 m3 in various aircraft, and trials undertaken on Boeing 747 and 767 aircraft showed that their air-conditioning systems do not preclude effective disinsection [3].
The diagnostic dose of d-phenothrin synergized 1:1 with piperonyl butoxide for testing insecticide susceptibility of mosquitoes by bottle bioassay is reported for 2 mosquito species, Culex quinquefasciatus and Ochlerotatus taeniorhynchus [4].
Indoor behavior and risk assessment following residual spraying of d-phenothrin and d-tetramethrin [5].

Chemical compound and disease context of S-2539-F

The highest dose level tested for d-phenothrin was a limit dose (1000 mg/kg per day) designated in the current draft protocol by the OECD, and in fact there was no excessive systemic toxicity in both assays; slightly increased liver weight but no change of serum androgen levels in accessing anti-androgenicity [6].

Biological context of S-2539-F

Treatment with d-phenothrin or d-allethrin decreased egg production, but tetramethrin increased oviposition [7].

Associations of S-2539-F with other chemical compounds

This resistance has developed after exclusive use of pyrethroids lotion and shampoo in the Czech Republic since 1978, and it was accompanied by a cross-resistance to d-phenothrin and bioalethrin [8].
The biological activity of permethrin, phenothrin/allethrin and d-phenothrin was evaluated against Periplaneta americana and Blattella germanica cockroaches [9].

Analytical, diagnostic and therapeutic context of S-2539-F

Diagnostic dose of synergized d-phenothrin for insecticide susceptibility testing by bottle bioassay [4].

References

Ovicidal and adulticidal activities of Cinnamomum zeylanicum bark essential oil compounds and related compounds against Pediculus humanus capitis (Anoplura: Pediculicidae). Yang, Y.C., Lee, H.S., Lee, S.H., Clark, J.M., Ahn, Y.J. Int. J. Parasitol. (2005) [Pubmed]
Controlled study of malathion and d-phenothrin lotions for Pediculus humanus var capitis-infested schoolchildren. Chosidow, O., Chastang, C., Brue, C., Bouvet, E., Izri, M., Monteny, N., Bastuji-Garin, S., Rousset, J.J., Revuz, J. Lancet (1994) [Pubmed]
In-flight disinsection as an efficacious procedure for preventing international transport of insects of public health importance. Russell, R.C., Paton, R. Bull. World Health Organ. (1989) [Pubmed]
Diagnostic dose of synergized d-phenothrin for insecticide susceptibility testing by bottle bioassay. Petersen, J.L., Floore, T.G., Brogdon, W.G. J. Am. Mosq. Control Assoc. (2004) [Pubmed]
Indoor behavior and risk assessment following residual spraying of d-phenothrin and d-tetramethrin. Matoba, Y., Takimoto, Y., Kato, T. American Industrial Hygiene Association journal. (1998) [Pubmed]
Lack of estrogenic or (anti-)androgenic effects of d-phenothrin in the uterotrophic and Hershberger assays. Yamada, T., Ueda, S., Yoshioka, K., Kawamura, S., Seki, T., Okuno, Y., Mikami, N. Toxicology (2003) [Pubmed]
Effect of three pyrethroids on blood feeding and fecundity of Aedes aegypti. Liu, W., Todd, R.G., Gerberg, E.J. J. Am. Mosq. Control Assoc. (1986) [Pubmed]
A resistance of head lice (Pediculus capitis) to permethrin in Czech Republic. Rupes, V., Moravec, J., Chmela, J., Ledvinka, J., Zelenková, J. Cent. Eur. J. Public Health (1995) [Pubmed]
Biological activity of permethrin, phenothrin/allerthrin and D-phenothrin on Periplaneta americana and Blattella germanica cockroaches. Lukwa, N., Manokore, V. East African medical journal. (1997) [Pubmed]

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