Disease relevance of HSDB 3922

• We tested four frequently encountered pyrethroids, fenvalerate, sumithrin, d-trans allethrin, and permethrin, for estrogen and progesterone agonist/antagonist activities using the Ishikawa Var-I human endometrial cancer cell line and the T47D human breast cancer cell line [1].
• However, there was little difference in toxicity between synergized and technical sumithrin until 48 h had elapsed [2].
• Sumithrin: from inception to integration within West Nile virus programs [3].
• CONCLUSION: The antiandrogenic activity of phenothrin may explain this unusual epidemic of gynecomastia [4].
• A separate case of live lice infestation was found at two weeks post-treatment in a subject treated with phenothrin lotion and at four weeks post-treatment in two subjects treated with carbaryl lotion [5].

High impact information on HSDB 3922

• METHODS: Head lice were collected from school children in four centres across England (Exmouth, Loughborough, Leeds and South Shields), and tested in their response to the insecticides permethrin, phenothrin, malathion and carbaryl [6].
• Both 17beta-estradiol (10(-10) M) and sumithrin (10(-5) M) decreased the levels of cytosolic ERalpha and ERbeta protein expression significantly as compared with the vehicle control [7].
• Of the pyrethroid insecticides tested, only sumithrin increased MCF-7 BUS cell proliferation in a dose-dependent manner; the maximum induction of cell proliferation was observed at a dose of 10(-5) M [7].
• Phenothrin, the "multi-cide" component of R&C Spray, reproduced this competitive binding result [4].
• Phenothrin-susceptible and -resistant head louse colonies from Japanese were individually analyzed for point mutations of the sodium channel cDNA; susceptible head and body lice differed in double homozygous synonymous substitutions [8].

Chemical compound and disease context of HSDB 3922

• We conducted toxicity tests with brook trout (Salvelinus fontinalis) and brown trout (Salmo trutta) to compare the toxicity of synergized and technical formulations of permethrin, sumithrin, and resmethrin [2].

Biological context of HSDB 3922

• Kinetics and photophysical mechanism of sunlight photolysis of unstable resmethrin and phenothrin in aerosols and thin films [9].

Associations of HSDB 3922 with other chemical compounds

• A study of some insecticidal properties of a new pyrethroid, permethrin, showed that it was a highly effective insecticide at contact, superior in this respect to neopinamin for German cockroaches, houseflies and bedbugs and superior to sumithrin for German cockroaches [10].
• When compared to the solvent-treated controls, sumithrin, fenvalerate and estrogen treated MCF-7 cells all had increased levels of WNT10B expression [11].

Analytical, diagnostic and therapeutic context of HSDB 3922

• Reinspection two weeks after initiation of treatment revealed two apparent treatment failures in the carbaryl group and one in the phenothrin group [12].
• Long term follow-up after Sumithrin powder application for head louse control in a primary school showed that the infestation rate dropped from 33.1% before treatment to 5.4% by seven months after treatment, giving a 83.4% reduction rate [13].

References