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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Czech Republic

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Disease relevance of Czech Republic

  • To prove whether the interaction between insertion/deletion (I/D) angiotensin I converting enzyme (ACE) and M235T angiotensinogen (AGT) gene polymorphic alleles could contribute to causing essential hypertension, we examined subjects from the Czech Republic (365 Caucasians total; 202 normotensives and 163 hypertensives) [1].
  • Methicillin-resistant Staphylococcus aureus clonal types in the Czech Republic [2].
  • CONCLUSIONS: Urine screening was an efficient and accurate method for identifying groups at risk for STDs in the Czech Republic and Slovakia because sample collection was fast and noninvasive, and potential participation bias was reduced by high acceptability [3].
  • We analyzed the genetic diversity of HIV-1 strains circulating in the Czech Republic. Phylogenetic analysis of the env and gag gene sequence fragments from 39 isolates revealed that the majority of these strains (32 of 39, 82%) were of subtype B; other genetic subtypes identified were A, C, F, and recombinant circulating form CRF01_AE [4].
  • Stenotrophomonas maltophilia (298/85) was isolated from the extensively inflamed conjunctiva of a neonate in a regional hospital in Ostrava, Czech Republic. It was resistant to all available antibiotics except cefepime and trimethoprim [5].

High impact information on Czech Republic

  • The Czech Republic is among the most aggressive of the former Warsaw Pact countries in encouraging competition and free-market reform [6].
  • Here we report the first comprehensive study of eight unrelated families with NPC2, originating from France, Algeria, Italy, Germany, the Czech Republic, and Turkey [7].
  • The first is a 7-bp deletion (del5985-5991) found in a Caucasian family from Ohio. The second mutation (5967insT) was found in a Caucasian family from the Czech Republic. In both cases the EPO dose responses of the erythroid progenitors of the affected subjects were examined to confirm the diagnosis of PFCP [8].
  • Genetic epidemiology of MODY in the Czech republic: new mutations in the MODY genes HNF-4alpha, GCK and HNF-1alpha [9].
  • Prevalence of resistance mechanisms against macrolides and lincosamides in methicillin-resistant coagulase-negative staphylococci in the Czech Republic and occurrence of an undefined mechanism of resistance to lincosamides [10].

Chemical compound and disease context of Czech Republic


Biological context of Czech Republic


Anatomical context of Czech Republic


Associations of Czech Republic with chemical compounds

  • Using this system, we assessed 245 clinical isolates of Candida from patients in the hospital of the Faculty of Medicine, Palacky University, Olomouc, Czech Republic, for the presence of secreted aspartic proteases (Saps) [23].
  • One hundred and thirty-five patients from Germany, Denmark, the Czech Republic, Spain, and the United States were selected for this study on the basis of abnormal EMA excretion ranging from 18 to 1185 mmol/mol of creatinine (controls < 18 mmol/mol of creatinine) [24].
  • METHODS: Prostitutes working in night clubs and in the streets and roads of three districts in the West Bohemian Region of the Czech Republic bordering on Germany were studied [25].
  • Genotoxicity of urban air pollutants in the Czech Republic. Part I. Bacterial mutagenic potencies of organic compounds adsorbed on PM10 particulates [26].
  • The genetic population structure of Polyommatus coridon (Poda, 1761) (Chalk-hill blue) was studied by means of allozyme electrophoresis in north-eastern Germany, the Czech Republic, Slovakia and Hungary [27].

Gene context of Czech Republic

  • We show that in the Czech Republic the Delta(GJB6-D13S1830) is not the second most common causal factor in deafness patients heterozygous for a single GJB2 mutation, and that Delta(GJB6-D13S1830) is very rare in central Europe compared to reports from Spain, France and Israel [28].
  • The aim of this study was to analyse the BRCA1 gene in the ovarian cancer risk group to characterize the spectrum of its mutations in the Czech Republic. Five overlapping fragments amplified on both genomic DNA and cDNA were used to screen for the whole protein-coding sequence of the BRCA1 gene [29].
  • Based on our results, genotyping of CHEK2 c.1100delC mutation in clinical settings in the Czech Republic could not be recommended [19].
  • COL6A1 was examined for susceptibility in DISH patients from Japan and the Czech Republic. METHODS: Seven single nucleotide polymorphisms of COL6A1 were genotyped by direct sequencing [30].
  • BRCA1 and BRCA2 mutations in women with familial or early-onset breast/ovarian cancer in the Czech Republic [31].

Analytical, diagnostic and therapeutic context of Czech Republic


  1. Angiotensin I-converting enzyme and angiotensinogen gene interaction and prediction of essential hypertension. Vasků, A., Soucek, M., Znojil, V., Rihácek, I., Tschöplová, S., Strelcová, L., Cídl, K., Blazková, M., Hájek, D., Hollá, L., Vácha, J. Kidney Int. (1998) [Pubmed]
  2. Methicillin-resistant Staphylococcus aureus clonal types in the Czech Republic. Melter, O., Santos Sanches, I., Schindler, J., Aires de Sousa, M., Mato, R., Kovárova, V., Zemlicková, H., de Lencastre, H. J. Clin. Microbiol. (1999) [Pubmed]
  3. Chlamydia, gonorrhea, and HIV-1 prevalence among five populations of women in the Czech and Slovak Republics. Kacena, K.A., Dohnal, K., Benesova, V., Grivna, M., Deliopolu, J., Trýzna, R., Horák, J., Gaydos, C.A., Quinn, T.C. Sexually transmitted diseases. (2001) [Pubmed]
  4. Genetic subtypes of HIV type 1 viruses circulating in the Czech Republic. Reinis, M., Brucková, M., Graham, R.R., Vandasová, J., Stanková, M., Carr, J.K. AIDS Res. Hum. Retroviruses (2001) [Pubmed]
  5. Transferable antibiotic resistance in nosocomial Stenotrophomonas maltophilia strain. Blahová, J., Králiková, K., Krcméry, V., Torsová, V. Diagn. Microbiol. Infect. Dis. (1997) [Pubmed]
  6. Health system reform in the Czech Republic. Policy lessons from the initial experience of the general health insurance company. Massaro, T.A., Nemec, J., Kalman, I. JAMA (1994) [Pubmed]
  7. Niemann-Pick disease type C: spectrum of HE1 mutations and genotype/phenotype correlations in the NPC2 group. Millat, G., Chikh, K., Naureckiene, S., Sleat, D.E., Fensom, A.H., Higaki, K., Elleder, M., Lobel, P., Vanier, M.T. Am. J. Hum. Genet. (2001) [Pubmed]
  8. Two new EPO receptor mutations: truncated EPO receptors are most frequently associated with primary familial and congenital polycythemias. Kralovics, R., Indrak, K., Stopka, T., Berman, B.W., Prchal, J.F., Prchal, J.T. Blood (1997) [Pubmed]
  9. Genetic epidemiology of MODY in the Czech republic: new mutations in the MODY genes HNF-4alpha, GCK and HNF-1alpha. Pruhova, S., Ek, J., Lebl, J., Sumnik, Z., Saudek, F., Andel, M., Pedersen, O., Hansen, T. Diabetologia (2003) [Pubmed]
  10. Prevalence of resistance mechanisms against macrolides and lincosamides in methicillin-resistant coagulase-negative staphylococci in the Czech Republic and occurrence of an undefined mechanism of resistance to lincosamides. Novotna, G., Adamkova, V., Janata, J., Melter, O., Spizek, J. Antimicrob. Agents Chemother. (2005) [Pubmed]
  11. Uptake of thallium from naturally-contaminated soils into vegetables. Pavlícková, J., Zbíral, J., Smatanová, M., Habarta, P., Houserová, P., Kubán, V. Food additives and contaminants. (2006) [Pubmed]
  12. The 2001 serological survey in the Czech Republic--invasive meningococcal disease. Krízová, P. Cent. Eur. J. Public Health (2003) [Pubmed]
  13. Infantile sialic acid storage disease (ISSD). Report on first case in Czech Republic with biopsy and autopsy findings. Elleder, M., Kraus, J., Kodet, R. Sborník lékar̆ský. (1993) [Pubmed]
  14. The detection of proviral DNA by semi-nested polymerase chain reaction and phylogenetic analysis of Czech Maedi-Visna isolates based on gag gene sequences. Celer, V., Celer, V., Nejedlá, E., Bertoni, G., Peterhans, E., Zanoni, R.G. J. Vet. Med. B Infect. Dis. Vet. Public Health (2000) [Pubmed]
  15. Are we ready to curtail testing for TEL/AML1 fusion? Pediatric Hematology Working Group in the Czech Republic. Hrusák, O., Trka, J., Zuna, J., Bartůnková, J., Starý, J. Leukemia (1999) [Pubmed]
  16. Biological activities of organic compounds adsorbed onto ambient air particles: comparison between the cities of Teplice and Prague during the summer and winter seasons 2000-2001. Binková, B., Cerná, M., Pastorková, A., Jelínek, R., Benes, I., Novák, J., Srám, R.J. Mutat. Res. (2003) [Pubmed]
  17. Laser-assisted subepithelial keratectomy for myopia: two-year follow-up. Autrata, R., Rehurek, J. Journal of cataract and refractive surgery. (2003) [Pubmed]
  18. Cardiovascular risk factors in young Czech females with polycystic ovary syndrome. Vrbíková, J., Cífková, R., Jirkovská, A., Lánská, V., Platilová, H., Zamrazil, V., Stárka, L. Hum. Reprod. (2003) [Pubmed]
  19. The CHEK2 c.1100delC germline mutation rarely contributes to breast cancer development in the Czech Republic. Kleibl, Z., Novotny, J., Bezdickova, D., Malik, R., Kleiblova, P., Foretova, L., Petruzelka, L., Ilencikova, D., Cinek, P., Pohlreich, P. Breast Cancer Res. Treat. (2005) [Pubmed]
  20. Screening of six risk exons of the RET proto-oncogene in families with medullary thyroid carcinoma in the Czech Republic. Jindrichová, S., Vcelák, J., Vlcek, P., Neradilová, M., Nemec, J., Bendlová, B. J. Endocrinol. (2004) [Pubmed]
  21. Structural changes in fluorosed dental enamel of red deer (Cervus elaphus L.) from a region with severe environmental pollution by fluorides. Kierdorf, U., Kierdorf, H., Sedlacek, F., Fejerskov, O. J. Anat. (1996) [Pubmed]
  22. Health risk assessment of the mycotoxin ochratoxin A to humans: Czech Republic--Brno--1991/92. Ruprich, J., Ostrý, V. Cent. Eur. J. Public Health (1993) [Pubmed]
  23. Simple method for screening Candida species isolates for the presence of secreted proteinases: a tool for the prediction of successful inhibitory treatment. Dostál, J., Hamal, P., Pavlícková, L., Soucek, M., Ruml, T., Pichová, I., Hrusková-Heidingsfeldová, O. J. Clin. Microbiol. (2003) [Pubmed]
  24. Ethylmalonic aciduria is associated with an amino acid variant of short chain acyl-coenzyme A dehydrogenase. Corydon, M.J., Gregersen, N., Lehnert, W., Ribes, A., Rinaldo, P., Kmoch, S., Christensen, E., Kristensen, T.J., Andresen, B.S., Bross, P., Winter, V., Martinez, G., Neve, S., Jensen, T.G., Bolund, L., Kølvraa, S. Pediatr. Res. (1996) [Pubmed]
  25. Prevalence of STDs among prostitutes in Czech border areas with Germany in 1997-2001 assessed in project "Jana". Resl, V., Kumpová, M., Cerná, L., Novák, M., Pazdiora, P. Sexually transmitted infections. (2003) [Pubmed]
  26. Genotoxicity of urban air pollutants in the Czech Republic. Part I. Bacterial mutagenic potencies of organic compounds adsorbed on PM10 particulates. Cerná, M., Pochmanová, D., Pastorková, A., Benes, I., Lenícek, J., Topinka, J., Binková, B. Mutat. Res. (2000) [Pubmed]
  27. Postglacial distribution area expansion of Polyommatus coridon (Lepidoptera: Lycaenidae) from its Ponto-Mediterranean glacial refugium. Schmitt, T., Seitz, A. Heredity (2002) [Pubmed]
  28. Double heterozygosity with mutations involving both the GJB2 and GJB6 genes is a possible, but very rare, cause of congenital deafness in the Czech population. Seeman, P., Bendová, O., Rasková, D., Malíková, M., Groh, D., Kabelka, Z. Ann. Hum. Genet. (2005) [Pubmed]
  29. Mutational analysis of the BRCA1 gene in 30 Czech ovarian cancer patients. Zikan, M., Pohlreich, P., Stribrna, J. J. Genet. (2005) [Pubmed]
  30. COL6A1, the candidate gene for ossification of the posterior longitudinal ligament, is associated with diffuse idiopathic skeletal hyperostosis in Japanese. Tsukahara, S., Miyazawa, N., Akagawa, H., Forejtova, S., Pavelka, K., Tanaka, T., Toh, S., Tajima, A., Akiyama, I., Inoue, I. Spine. (2005) [Pubmed]
  31. BRCA1 and BRCA2 mutations in women with familial or early-onset breast/ovarian cancer in the Czech Republic. Foretova, L., Machackova, E., Navratilova, M., Pavlu, H., Hruba, M., Lukesova, M., Valik, D. Hum. Mutat. (2004) [Pubmed]
  32. Evaluation of the immunotech cyclosporine direct radioimmunoassay for the determination of whole-blood cyclosporine in renal transplant patients. Westley, I.S., Sallustio, B.C., Morris, R.G. Therapeutic drug monitoring. (2005) [Pubmed]
  33. Molecular epidemiology of HIV type 1 isolates from the Czech Republic: identification of an env E subtype case. Quiñones-Mateu, M.E., Albright, J.L., Torre, V., Reinis, M., Vandasová, J., Brucková, M., Arts, E.J. AIDS Res. Hum. Retroviruses (1999) [Pubmed]
  34. Nutrition in ten-year-old children of the Liberec area (Czech Republic). Soltysova, T., Bellisle, F. Ann. Nutr. Metab. (1994) [Pubmed]
  35. A six-year study of hydroxyapatite-coated root-form dental implants. Simunek, A., Kopecka, D., Cierny, M., Krulichova, I. The West Indian medical journal. (2005) [Pubmed]
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