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Chemical Compound Review

AC1MHYZP     2-[(1S)-1,2-dihydroxyethyl]- 5-hydroxy-4...

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Disease relevance of CCRIS 4543


High impact information on CCRIS 4543


Chemical compound and disease context of CCRIS 4543


Biological context of CCRIS 4543

  • We concluded that CV-3611 could reduce significantly the susceptibility to reperfusion-induced arrhythmias, especially VF, and that its effect may be due to the elimination of oxygen-derived free radicals by CV-3611 present in the membrane and the capture of lipid radicals, thereby inhibiting lipid peroxidation [5].
  • The effects of CV-3611, a new free radical scavenger, on coronary circulation failure and infarct size after ischemia/reperfusion were studied in conscious beagle dogs [12].

Anatomical context of CCRIS 4543


Associations of CCRIS 4543 with other chemical compounds


Analytical, diagnostic and therapeutic context of CCRIS 4543

  • Dogs were randomly assigned to receive CV-3611 (5[5 min]-1, intravenously) just before the onset of reperfusion [15].
  • Furthermore, CV-3611 reduced the incidence of sustained VF in a dose-dependent manner, from 67% in the control group to 13% in the CV-3611, 20 mg/kg treated group (p less than 0.01) [5].
  • The circulation half life of CV-3611 was checked by a reversed-phase HPLC after 10 mg/kg s.c. administration [16].


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  2. Suppression of spontaneous hepatocellular carcinoma development in C3H/HeNCrj mice by the lipophilic ascorbic acid, 2-O-octadecylascorbic acid (CV-3611). Kushida, H., Wakabayashi, K., Suzuki, M., Takahashi, S., Imaida, K., Sugimura, T., Nagao, M. Carcinogenesis (1992) [Pubmed]
  3. Dual inhibitors of thromboxane A2 synthase and 5-lipoxygenase with scavenging activity of active oxygen species. Synthesis of a novel series of (3-pyridylmethyl)benzoquinone derivatives. Ohkawa, S., Terao, S., Terashita, Z., Shibouta, Y., Nishikawa, K. J. Med. Chem. (1991) [Pubmed]
  4. Preventive effect of zelandopam, a dopamine D1 receptor agonist, on cisplatin-induced acute renal failure in rats. Yatsu, T., Aoki, M., Inagaki, O. Eur. J. Pharmacol. (2003) [Pubmed]
  5. Effects of pretreatment with 2-O-octadecylascorbic acid, a novel free radical scavenger, on reperfusion-induced arrhythmias in isolated perfused rat hearts. Tada, H., Kutsumi, Y., Misawa, T., Shimamoto, N., Nakai, T., Miyabo, S. J. Cardiovasc. Pharmacol. (1990) [Pubmed]
  6. 3-O-alkylascorbic acids as free radical quenchers. 3. Protective effect on coronary occlusion-reperfusion induced arrhythmias in anesthetized rats. Nihro, Y., Sogawa, S., Izumi, A., Sasamori, A., Sudo, T., Miki, T., Matsumoto, H., Satoh, T. J. Med. Chem. (1992) [Pubmed]
  7. Studies on scavengers of active oxygen species. 1. Synthesis and biological activity of 2-O-alkylascorbic acids. Kato, K., Terao, S., Shimamoto, N., Hirata, M. J. Med. Chem. (1988) [Pubmed]
  8. Inhibitory effect of 2-O-octadecylascorbic acid in agglutination assay with concanavalin A; short-term examination of rat urinary bladder carcinogenesis. Suzuki, M., Wakabayashi, K., Sone, H., Kushida, H., Sugiyama, K., Kakizoe, T., Nagao, M., Sugimura, T. Jpn. J. Cancer Res. (1991) [Pubmed]
  9. Evidence for a role of free radicals by synthesized scavenger, 2-octadecylascorbic acid, in cerulein-induced mouse acute pancreatitis. Nonaka, A., Manabe, T., Kyogoku, T., Tamura, K., Tobe, T. Dig. Dis. Sci. (1992) [Pubmed]
  10. Involvement of oxygen free radicals in experimental retinal ischemia and the selective vulnerability of retinal damage. Kuriyama, H., Waki, M., Nakagawa, M., Tsuda, M. Ophthalmic Res. (2001) [Pubmed]
  11. Oxidative stress in acute pancreatitis. Schulz, H.U., Niederau, C., Klonowski-Stumpe, H., Halangk, W., Luthen, R., Lippert, H. Hepatogastroenterology (1999) [Pubmed]
  12. Effects of CV-3611, a new free radical scavenger, on ischemic heart failure in conscious beagle dogs. Tanabe, M., Kito, G. Jpn. J. Pharmacol. (1989) [Pubmed]
  13. Effects of some radical scavengers on reperfusion-induced arrhythmias in the canine heart. Takekoshi, N., Murakami, E., Ohkubo, S. Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy. (1991) [Pubmed]
  14. Reperfusion injury in bone: effects of CV-3611, a free radical scavenger, on ischemic revascularized bone grafts in rats. Tamura, Y., Inoue, G., Miura, T., Ishiguro, N., Shimizu, T. Journal of reconstructive microsurgery. (1992) [Pubmed]
  15. Role of free radicals and neutrophils in canine myocardial reperfusion injury: myocardial salvage by a novel free radical scavenger, 2-octadecylascorbic acid. Kuzuya, T., Hoshida, S., Nishida, M., Kim, Y., Fuji, H., Kitabatake, A., Kamada, T., Tada, M. Cardiovasc. Res. (1989) [Pubmed]
  16. Effect of a new synthetic free radical scavenger, 2-octadecyl ascorbic acid, on the mortality in mouse endotoxemia. Nonaka, A., Manabe, T., Tobe, T. Life Sci. (1990) [Pubmed]
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