Disease relevance of Coronary Circulation

• Release of prostaglandins and thromboxane into the coronary circulation in patients with ischemic heart disease [1].
• We therefore measured the release of prostaglandins and thromboxane into the coronary circulation in patients with various kinds of cardiac disease [1].
• Because serotonin possesses both vasodilator and vasoconstrictor properties, we examined its effect in the coronary circulation distal to an arterial stenosis that resulted in myocardial hypoperfusion during exercise [2].
• Acute effects of captopril on the coronary circulation of patients with hypertension and angina [3].
• This study investigated the effect of intravenous cocaine (0.5 to 2 mg/kg body weight) on the coronary circulation and systemic hemodynamics in closed chest sedated dogs [4].

High impact information on Coronary Circulation

• Serotonin is released into the coronary circulation during angioplasty, and this vasoactive substance may contribute to the occurrence of vasoconstriction distal to the dilated site [5].
• All had either normal or noncritical luminal irregularities of dominant right coronary arteries and more than 75 per cent occlusions in the left coronary circulation [6].
• When given before or immediately after ischemic injury, transforming growth factor-beta (TGF-beta) reduced the amount of superoxide anions in the coronary circulation, maintained endothelial-dependent coronary relaxation, and reduced injury mediated by exogenous TNF [7].
• Injection of synthetic bovine parathyroid hormone (the amino terminal peptide containing the first 34 amino acids) to the coronary circulation of the dog resulted in a marked coronary vasodilation [8].
• In a second group of nine dogs, dobutamine was administered systemically to assure a constant concentration in the coronary circulation [9].

Chemical compound and disease context of Coronary Circulation

• This unusual generalized inhibition of platelet function by nitroglycerin possibly contributes to its beneficial effect in myocardial ischemia in part by attenuating platelet reactivity in the coronary circulation [10].
• Endothelin-dependent modulation of vasoconstrictor action in the coronary circulation in early salt-induced experimental hypertension [11].
• This study was designed to determine whether vitamin E is actually consumed in the coronary circulation in patients with active variant angina having repetitive spasm-induced transient myocardial ischemia and reperfusion [12].
• Since intracoronary infusion of adenosine increased, rather than inhibited, vasoconstrictor responses to angiotensin, it is unlikely that release of adenosine during hypoxemia accounts for inhibition of vasoconstriction in the coronary circulation [13].
• Response of rat coronary circulation to carbon monoxide and nitrogen hypoxia [14].

Biological context of Coronary Circulation

• Tracer norepinephrine kinetics in coronary circulation of patients with heart failure secondary to chronic pressure and volume overload [15].
• The present work was designed to delineate--independently from its systemic effects--the intrinsic actions of an angiotensin converting-enzyme inhibitor on the coronary circulation and left ventricular function [16].
• The effects of cocaine on the coronary circulation were examined in conscious dogs chronically instrumented to measure arterial and left ventricular pressures, coronary blood flow, and arterial and coronary sinus oxygen content [17].
• Authentic NO applied into the coronary circulation decreased vascular resistance dose dependently and enhanced coronary release of cyclic GMP (cGMP) fivefold [18].
• These data indicate that pacing-induced myocardial ischemia does not result in release of fibrinopeptide A, platelet factor 4, beta-thromboglobulin or thromboxane B2 into the coronary circulation, and imply that acute ischemia does not induce platelet activation or fibrin formation in the coronary circulation [19].

Anatomical context of Coronary Circulation

• These findings suggest that L-PGDS is present in both endocardium and myocardium of normal subjects and the stenotic site of patients with stable angina and is secreted into the coronary circulation [20].
• BACKGROUND: Bradykinin is a potent stimulator of tPA secretion in endothelial cells; however, the effect of BK on tPA release in the human coronary circulation has not been studied [21].
• Autologous, primary rabbit skeletal myoblasts were harvested, were transduced ex vivo with adenoviruses expressing the Escherichia coli beta-galactosidase (beta-gal) gene, and were infused selectively into the coronary circulation or injected directly into the myocardial wall [22].
• Nitrite entered trout erythrocytes independent of degree of oxygenation, but the O(2) saturation of RBCs showed a major decrease in the coronary circulation, and [NO(2)(-)] decreased while methaemoglobin rose, suggesting that deoxyHb-mediated reduction of nitrite to NO may have occurred [23].
• The relationship between left ventricular function and coronary blood flow was studied in 16 chloralose-anesthetized dogs with an intact coronary circulation and left ventricle [24].

Associations of Coronary Circulation with chemical compounds

• This study assessed the effects of NPY on the coronary circulation in 40 chloralose-anesthetized, open-chest dogs [25].
• Whether L-arginine reverses hypercholesterolaemia-induced endothelial dysfunction in the coronary circulation was thus investigated [26].
• BACKGROUND: Adenosine, a physiological coronary vasodilator, has been proposed to regulate coronary circulation according to myocardial oxygen demand [27].
• Differential influences of angiotensin converting-enzyme inhibitors on the coronary circulation [28].
• To understand the mechanisms involved, we evaluated the direct effect of nitroglycerin on coronary circulation of the ischemic hearts [29].

Gene context of Coronary Circulation

• Evidence against a major role for angiotensin converting enzyme-related carboxypeptidase (ACE2) in angiotensin peptide metabolism in the human coronary circulation [30].
• We could observe serial changes in plasma MMP-1 levels in the coronary circulation only in one patient, because MMP-1 levels were lower than the limit of detection in other patients [31].
• We investigated changes in chemokine expression in the coronary circulation induced by percutaneous transluminal coronary angioplasty (PTCA) and their clinical significance [32].
• These results broaden the molecular basis for understanding and manipulating VEGF-induced endothelial function and angiogenesis in the coronary circulation [33].
• Soluble E-selectin, ICAM-1 and VCAM-1 levels in systemic and coronary circulation in patients with variant angina [34].

Analytical, diagnostic and therapeutic context of Coronary Circulation

• To investigate the ability of arginine vasopressin (AVP) to compete with metabolic vasodilatory factors in the coronary circulation, we examined the coronary vascular and myocardial effects of AVP in isolated working rat hearts during normoxic and hypoxic perfusion [35].
• Therefore, the effects of 1) high doses of nifedipine, given intravenously at 30 min after reperfusion, and 2) minute doses of nifedipine, infused directly into the coronary circulation at 30 min after reflow, were assessed and compared in anesthetized open chest dogs subjected to 15 min of transient coronary artery occlusion [36].
• Isolated rat hearts were perfusion-fixed through the coronary circulation, stained with lanthanum or tannic acid, and further processed for transmission electron microscopy [37].
• It is concluded that the effect of endothelin-1 on coronary circulation in situ was mainly due to the constriction of small resistant vessels [38].
• PTCA induced increases in plasma levels of M-CSF in the coronary circulation [32].

References