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Chemical Compound Review

AC1MIWOC     azane; 2-(4-hydroxyphenoxy)ethanoic acid;...

Synonyms: RG-13577, RG 13577, 146058-45-9
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  • RESULTS: Five of the 6 animals receiving an RG-13577/ATA-coated stent experienced acute stent thrombosis, while no adverse events occurred in the animals of the other 2 groups [1].
  • In this study we clarify the mode of action of RG-13577 and demonstrate that the RG-13577-induced hypertrophy is associated with an increased expression of TGF-beta1 as indicated by an increase in TGF-beta1-specific protein and mRNA level [2].

High impact information on P-HYDROXYPHENOXYACETIC ACID

  • RG-13577 inhibited FGF-2 binding to soluble- and cell surface-FGF receptor 1 (FGFR1) [3].
  • METHODS AND RESULTS: Injured and noninjured saphenous vein segments were perfused with or without heparin, in the absence or presence of 125I-bFGF and/or RG-13577 (a polymer of 4-hydroxyphenoxy acetic acid) [4].
  • In a search for a superior antiproliferative agent, a synthetic polyaromatic "heparin mimicking" compound (RG-13577, polymer of 4-hydroxyphenoxy acetic acid, M(r) approximately 5800), previously reported to inhibit the proliferation of vascular smooth muscle cells, was applied [5].
  • RG-13577 binds to a naturally produced extracellular matrix, and the bound molecule retained its antiproliferative effect toward MC [5].
  • Furthermore, the antiproliferative effect of RG-13577 was abolished in the presence of lactoferrin [5].

Chemical compound and disease context of P-HYDROXYPHENOXYACETIC ACID







  • One has here investigated the effects of RG-13577 on LPL, both after intravenous injection to rats and under cell culture conditions [7].
  • These results indicate that RG-13577 and related compounds bind to the LRP receptor on the surface of vascular SMCs [8].
  • There was a slight increase in TF staining around the stent struts, while SEM showed increased platelet adhesion and activity in RG-13577/ATA-coated stents versus the ATA-coated and bare metal stents [1].

Analytical, diagnostic and therapeutic context of P-HYDROXYPHENOXYACETIC ACID


  1. Paradoxical effects of aurintricarboxylic acid and RG-13577: acute thrombosis and in-stent stenosis in a passive-coated stent. Strehblow, C., Sperker, W., Hevesi, A., Garamvölgyi, R., Petrasi, Z., Shirazi, M., Sylvén, C., Weiss, T., Lotan, C., Pugatsch, T., Ben-Sasson, S.A., Orlowski, M., Glogar, D., Gyöngyösi, M. J. Endovasc. Ther. (2006) [Pubmed]
  2. Induction of a hypertrophic growth status of coronary smooth muscle cells is associated with an overexpression of TGF-beta. Schmidt, A., Göpfert, C., Vlodavsky, I., Völker, W., Buddecke, E. Eur. J. Cell Biol. (2002) [Pubmed]
  3. Modulation of fibroblast growth factor-2 receptor binding, dimerization, signaling, and angiogenic activity by a synthetic heparin-mimicking polyanionic compound. Miao, H.Q., Ornitz, D.M., Aingorn, E., Ben-Sasson, S.A., Vlodavsky, I. J. Clin. Invest. (1997) [Pubmed]
  4. Endogenous basic fibroblast growth factor displaced by heparin from the lumenal surface of human blood vessels is preferentially sequestered by injured regions of the vessel wall. Medalion, B., Merin, G., Aingorn, H., Miao, H.Q., Nagler, A., Elami, A., Ishai-Michaeli, R., Vlodavsky, I. Circulation (1997) [Pubmed]
  5. Antiproliferative activity to glomerular mesangial cells and receptor binding of a heparin-mimicking polyaromatic anionic compound. Katz, A., Vlodavsky, I., Davies, M., Miao, H.Q., Ben-Sasson, S.A., Darmon, D., Hurwitz, H., Borgel, H., Benezra, M. J. Am. Soc. Nephrol. (1997) [Pubmed]
  6. A synthetic heparin-mimicking polyanionic compound inhibits central nervous system inflammation. Irony-Tur-Sinai, M., Vlodavsky, I., Ben-Sasson, S.A., Pinto, F., Sicsic, C., Brenner, T. J. Neurol. Sci. (2003) [Pubmed]
  7. Effects of the heparin-mimicking compound RG-13577 on lipoprotein lipase and on lipase mediated binding of LDL to cells. Neuger, L., Ruge, T., Makoveichuk, E., Vlodavsky, I., Olivecrona, G. Atherosclerosis (2001) [Pubmed]
  8. A synthetic heparin-mimicking polyanionic compound binds to the LDL receptor-related protein and inhibits vascular smooth muscle cell proliferation. Benezra, M., Vogel, T., Ben-Sasson, S.A., Panet, A., Sehayek, E., Al-Haideiri, M., Decklbaum, R.J., Vlodavsky, I. J. Cell. Biochem. (2001) [Pubmed]
  9. Improved reverse thermo-responsive polymeric systems. Cohn, D., Sosnik, A., Levy, A. Biomaterials (2003) [Pubmed]
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