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Chemical Compound Review

Aluminon     5-[(3-carboxy-4-hydroxy- phenyl)-(3-carboxy...

Synonyms: Lopac-A-1895, Dupont ATA, SureCN98495, CHEMBL275938, AG-K-23058, ...
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Disease relevance of Aluminon


High impact information on Aluminon


Chemical compound and disease context of Aluminon


Biological context of Aluminon


Anatomical context of Aluminon


Associations of Aluminon with other chemical compounds


Gene context of Aluminon


Analytical, diagnostic and therapeutic context of Aluminon

  • The Aluminon stain was also positive in one of three cases of osteitis fibrosa and three of four mild lesions, whereas it was negative in all biopsies from the control group [31].
  • Moreover, addition of ATA to VP16-treated MOLT-4 cells also resulted in production of apoptotic bodies, this effect being quantified by morphological examination and flow cytometry [32].
  • These investigations have identified a compound (aurintricarboxylic acid or ATA) that enhances transfection activity of "naked" plasmid and pulsed electrical fields (electroporation or EP) that synergistically boosts transgene expression to an average of 115-fold more than that observed with free DNA (P < 0.00009) [33].
  • Fourteen individuals on long term hemodialysis, with varying amounts of aluminum in bone from 11 to 296 mg/kg by flameless atomic absorption spectrophotometry, were examined to see whether the aluminon or acid solochrome azurine (ASA) staining reactions best approximated the chemical determination [34].
  • Inclusion of aurintricarboxylic acid (ATA) in extraction buffers for the isolation of RNA from animal tissues resulted in high yields (0.5-2.0 mg/g of tissue) of undegraded material as judged by agarose-gel-electrophoretic analyses and Northern-blotting experiments [35].


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  10. Dextran sulfate and other polyanionic anti-HIV compounds specifically interact with the viral gp120 glycoprotein expressed by T-cells persistently infected with HIV-1. Schols, D., Pauwels, R., Desmyter, J., De Clercq, E. Virology (1990) [Pubmed]
  11. Cell death induced by beta-amyloid 1-40 in MES 23.5 hybrid clone: the role of nitric oxide and NMDA-gated channel activation leading to apoptosis. Le, W.D., Colom, L.V., Xie, W.J., Smith, R.G., Alexianu, M., Appel, S.H. Brain Res. (1995) [Pubmed]
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  14. Methylation-dependent translation of viral messenger RNAs in vitro. Both, G.W., Banerjee, A.K., Shatkin, A.J. Proc. Natl. Acad. Sci. U.S.A. (1975) [Pubmed]
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  16. Amino acids interfere with the ERK1/2-dependent control of macroautophagy by controlling the activation of Raf-1 in human colon cancer HT-29 cells. Pattingre, S., Bauvy, C., Codogno, P. J. Biol. Chem. (2003) [Pubmed]
  17. Inhibition of von Willebrand factor binding to platelet GP Ib by a fractionated aurintricarboxylic acid prevents restenosis after vascular injury in hamster carotid artery. Matsuno, H., Kozawa, O., Niwa, M., Uematsu, T. Circulation (1997) [Pubmed]
  18. Mitochondrial membrane biogenesis: identification of a precursor to yeast cytochrome c oxidase subunit II, an integral polypeptide. Sevarino, K.A., Poyton, R.O. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
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  20. Role of DNA fragmentation in T cell activation-induced apoptosis in vitro and in vivo. Mogil, R.J., Shi, Y., Bissonnette, R.P., Bromley, P., Yamaguchi, I., Green, D.R. J. Immunol. (1994) [Pubmed]
  21. Characterization of the association of two small molecular weight RNAs with eukaryotic polysomes. Gunning, P.W., Béguin, P., Shooter, E.M., Austin, L., Jeffrey, P.L. J. Biol. Chem. (1981) [Pubmed]
  22. Evidence that non-caspase proteases are required for chromatin degradation during apoptosis. Hughes, F.M., Evans-Storms, R.B., Cidlowski, J.A. Cell Death Differ. (1998) [Pubmed]
  23. Ubiquitin-lysozyme conjugates. Identification and characterization of an ATP-dependent protease from rabbit reticulocyte lysates. Hough, R., Pratt, G., Rechsteiner, M. J. Biol. Chem. (1986) [Pubmed]
  24. Glucose and tolbutamide induce apoptosis in pancreatic beta-cells. A process dependent on intracellular Ca2+ concentration. Efanova, I.B., Zaitsev, S.V., Zhivotovsky, B., Köhler, M., Efendić, S., Orrenius, S., Berggren, P.O. J. Biol. Chem. (1998) [Pubmed]
  25. Antiproliferative plant and synthetic polyphenolics are specific inhibitors of vertebrate inositol-1,4,5-trisphosphate 3-kinases and inositol polyphosphate multikinase. Mayr, G.W., Windhorst, S., Hillemeier, K. J. Biol. Chem. (2005) [Pubmed]
  26. Apoptotic vs. nonapoptotic cytotoxicity induced by hydrogen peroxide. Gardner, A.M., Xu, F.H., Fady, C., Jacoby, F.J., Duffey, D.C., Tu, Y., Lichtenstein, A. Free Radic. Biol. Med. (1997) [Pubmed]
  27. Activation of the Jak2-Stat5 signaling pathway in Nb2 lymphoma cells by an anti-apoptotic agent, aurintricarboxylic acid. Rui, H., Xu, J., Mehta, S., Fang, H., Williams, J., Dong, F., Grimley, P.M. J. Biol. Chem. (1998) [Pubmed]
  28. Aurintricarboxylic acid induces a distinct activation of the IGF-I receptor signaling within MDA-231 cells. Haimsohn, M., Beery, R., Karasik, A., Kanety, H., Geier, A. Endocrinology (2002) [Pubmed]
  29. Green tea polyphenol (-)-epigallocatechin gallate blocks epithelial barrier dysfunction provoked by IFN-gamma but not by IL-4. Watson, J.L., Ansari, S., Cameron, H., Wang, A., Akhtar, M., McKay, D.M. Am. J. Physiol. Gastrointest. Liver Physiol. (2004) [Pubmed]
  30. The interaction between components of the fibrinolytic system and GPIb/V/IX of platelets thrombus formation in mice. Matsuno, H., Kozawa, O., Ueshima, S., Matsuo, O., Collen, D., Uematsu, T. Br. J. Pharmacol. (2000) [Pubmed]
  31. Serum aluminum levels as a reflection of renal osteodystrophy status and bone surface aluminum staining. Hodsman, A.B., Steer, B.M. J. Am. Soc. Nephrol. (1992) [Pubmed]
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  35. Characterization and use of the potent ribonuclease inhibitor aurintricarboxylic acid for the isolation of RNA from animal tissues. Skidmore, A.F., Beebee, T.J. Biochem. J. (1989) [Pubmed]
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