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Chemical Compound Review

sJYHIabIKTp@     N-bromoethanamide

Synonyms: Lopac-B-2377, CCRIS 4590, AG-H-17412, CHEMBL1256514, ACMC-209pgg, ...
 
 
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Disease relevance of CCRIS 4590

 

High impact information on CCRIS 4590

 

Biological context of CCRIS 4590

 

Anatomical context of CCRIS 4590

 

Associations of CCRIS 4590 with other chemical compounds

 

Gene context of CCRIS 4590

  • Introduction of the electrophilic isothiocyanate and bromoacetamide groups on the para position of Phe3 and Phe5 was accomplished by incorporating Fmoc-Phe(p-NHAlloc) into the peptide followed by selective deprotection and modification [13].
  • Bromoacetamide derivatives having n-alkyl substituents (BrCH2CONH(CH2)nH, 1-n) and carboxyalkyl substituents (BrCH2CONH(CH2)nCOOH, 2-n) react with His-15 in lysozyme exclusively at N epsilon 2 at pH 5.5 and 40 degree C. Kinetic studies suggest that lysozyme has a small hydrophobic pocket that binds these reagents in the vicinity of His-15 [14].
  • Enthalpic and entropic determinants for the specificity of alkylation of the histidine-12 residue of ribonuclease A by four bromoacetamido nucleoside affinity labels and bromoacetamide [12].
 

Analytical, diagnostic and therapeutic context of CCRIS 4590

  • After treatment with either a proteolytic enzyme such as papain or the amino acid reagent N-bromoacetamide, the K current no longer inactivated rapidly, but decayed very slowly with a time constant of 500 to 750 ms [15].

References

  1. Kinetics of 9-aminoacridine block of single Na channels. Yamamoto, D., Yeh, J.Z. J. Gen. Physiol. (1984) [Pubmed]
  2. Characterization of K+ currents in rat malignant lymphocytes (Nb2 cells). Cukierman, S. J. Membr. Biol. (1992) [Pubmed]
  3. N-bromoacetamide removes a calcium-dependent component of channel opening from calcium-activated potassium channels in rat skeletal muscle. Pallotta, B.S. J. Gen. Physiol. (1985) [Pubmed]
  4. Effect of N-bromoacetamide on single sodium channel currents in excised membrane patches. Patlak, J., Horn, R. J. Gen. Physiol. (1982) [Pubmed]
  5. Synthetic glycosylation of proteins using N-(beta-saccharide) iodoacetamides: applications in site-specific glycosylation and solid-phase enzymic oligosaccharide synthesis. Wong, S.Y., Guile, G.R., Dwek, R.A., Arsequell, G. Biochem. J. (1994) [Pubmed]
  6. Quantification of exponential Na+ current activation in N-bromoacetamide-treated cardiac myocytes of guinea-pig. Mitsuiye, T., Noma, A. J. Physiol. (Lond.) (1993) [Pubmed]
  7. Reconstituted voltage-sensitive sodium channels from eel electroplax: activation of permeability by quaternary lidocaine, N-bromoacetamide, and N-bromosuccinimide. Cooper, E.C., Agnew, W.S. J. Membr. Biol. (1989) [Pubmed]
  8. Electron paramagnetic resonance studies on spin-labelling of pepsin: effects of temperature, pH and urea on its conformation. Aoshima, H., Naito, A., Hatano, H. Int. J. Pept. Protein Res. (1976) [Pubmed]
  9. Dynamics of strychnine block of single sodium channels in bovine chromaffin cells. Yamamoto, D. J. Physiol. (Lond.) (1986) [Pubmed]
  10. Mode of action of the molluscicide bromoacetamide. Wang, G.F., Song, G.M., Becker, W. Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. (1991) [Pubmed]
  11. Deuterium isotope effects on papain acylation. Evidence for lack of general base catalysis and for enzyme--leaving-group interaction. Polgár, L. Eur. J. Biochem. (1979) [Pubmed]
  12. Enthalpic and entropic determinants for the specificity of alkylation of the histidine-12 residue of ribonuclease A by four bromoacetamido nucleoside affinity labels and bromoacetamide. Pincus, M.R., Hummel, C.F., Brandt-Rauf, P.W., Carty, R.P. Int. J. Pept. Protein Res. (1990) [Pubmed]
  13. Dermorphin-based potential affinity labels for mu-opioid receptors. Choi, H., Murray, T.F., Aldrich, J.V. J. Pept. Res. (2003) [Pubmed]
  14. Nature of the binding site around and reactivity of histidine-15 in lysozyme. Yamada, H., Uozumi, F., Ishikawa, A., Imoto, T. J. Biochem. (1984) [Pubmed]
  15. Modification of K channel inactivation by papain and N-bromoacetamide. Matteson, D.R., Carmeliet, P. Biophys. J. (1988) [Pubmed]
 
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