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Gene Review

LYZ  -  lysozyme (renal amyloidosis)

Gallus gallus

Synonyms: LYZC
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Disease relevance of LYZ


Psychiatry related information on LYZ


High impact information on LYZ

  • Modular structure of a chicken lysozyme silencer: involvement of an unusual thyroid hormone receptor binding site [7].
  • We show that the chicken lysozyme silencer S-2.4 kb has many other characteristics in common with enhancer elements [7].
  • Conversely, a derivative of chicken lysozyme containing the last six amino acids of grp78 fails to be secreted and instead accumulates in the ER [8].
  • The kinetics and polarity of lysozyme secretion from one transformed cell clone were studied using cell monolayers grown on nitrocellulose filters [9].
  • Sequences in the promoter region of the chicken lysozyme gene required for steroid regulation and receptor binding [10].

Chemical compound and disease context of LYZ


Biological context of LYZ


Anatomical context of LYZ

  • Immunoadsorption of specific chicken oviduct polysomes. Isolation of ovalbumin, ovomucoid, and lysozyme messenger RNA [19].
  • Lysozyme mRNA was translated in a reticulocyte lysate with mixtures of radioactive amino acids [20].
  • We have previously defined cis-acting regions flanking the chicken lysozyme-gene domain that mediate the attachment of the chromatin to the nuclear scaffold [21].
  • Remarkably, ectopic coexpression of Myb and NF-M proteins in erythroid cells or fibroblasts was sufficient to induce endogenous markers of myeloid differentiation, like the mim-1 and lysozyme genes [22].
  • During weekly MER therapy, monocyte adherence, serum lysozyme, and ADCC of peripheral blood mononuclear cells to CRBC rose significantly within 4-7 days after the first dose (3.8-8.7 adherent cells/ml blood x 10(4), 7.6-10.8 microgram, and 34.4-41.4% target cell lysis, respectively) [23].

Associations of LYZ with chemical compounds


Other interactions of LYZ

  • Ovomucoid mean wheal diameters were significantly greater than wheal diameters in response to ovalbumin, lysozyme, and egg white extract at the three most concentrated of five dilutions tested: 0.01, 0.03, and 0.1 mg/ml (p < 0.01) [27].
  • From this library, ovomucoid cDNA and lysozyme cDNA-bearing plasmids have been identified [28].
  • Sequence comparison at the 5' end of the lysozyme, conalbumin and ovalbumin genes reveals only one region of partial homology, 140 nucleotides upstream from the mRNA start sites [16].
  • The crude egg white extract was passed through a cation exchanger Streamline trade mark SP and the bound lysozyme was eluted with 5% ammonium carbonate, pH 9.0, containing 1 M NaCl after elution of avidin [29].
  • Both the rate and the extent of ubiquitin-lysozyme conjugation, however, are significantly higher with this modified substrate [30].

Analytical, diagnostic and therapeutic context of LYZ


  1. Arrangement of coding and intervening sequences of chicken lysozyme gene. Lindenmaier, W., Nguyen-Huu, M.C., Lurz, R., Stratmann, M., Blin, N., Wurtz, T., Hauser, H.J., Sippel, A.E., Schütz, G. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  2. A negative element involved in vimentin gene expression. Farrell, F.X., Sax, C.M., Zehner, Z.E. Mol. Cell. Biol. (1990) [Pubmed]
  3. In vivo genomic footprinting of thyroid hormone-responsive genes in pituitary tumor cell lines. Kim, S.W., Ahn, I.M., Larsen, P.R. Mol. Cell. Biol. (1996) [Pubmed]
  4. The chicken lysozyme 5' matrix attachment region increases transcription from a heterologous promoter in heterologous cells and dampens position effects on the expression of transfected genes. Phi-Van, L., von Kries, J.P., Ostertag, W., Strätling, W.H. Mol. Cell. Biol. (1990) [Pubmed]
  5. Mapping the antigenic epitope for a monoclonal antibody against lysozyme. Smith-Gill, S.J., Wilson, A.C., Potter, M., Prager, E.M., Feldmann, R.J., Mainhart, C.R. J. Immunol. (1982) [Pubmed]
  6. Protein surface topology-probing by selective chemical modification and mass spectrometric peptide mapping. Suckau, D., Mak, M., Przybylski, M. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  7. Modular structure of a chicken lysozyme silencer: involvement of an unusual thyroid hormone receptor binding site. Baniahmad, A., Steiner, C., Köhne, A.C., Renkawitz, R. Cell (1990) [Pubmed]
  8. A C-terminal signal prevents secretion of luminal ER proteins. Munro, S., Pelham, H.R. Cell (1987) [Pubmed]
  9. Exocytotic pathways exist to both the apical and the basolateral cell surface of the polarized epithelial cell MDCK. Kondor-Koch, C., Bravo, R., Fuller, S.D., Cutler, D., Garoff, H. Cell (1985) [Pubmed]
  10. Sequences in the promoter region of the chicken lysozyme gene required for steroid regulation and receptor binding. Renkawitz, R., Schütz, G., von der Ahe, D., Beato, M. Cell (1984) [Pubmed]
  11. Interactions of non-detergent sulfobetaines with early folding intermediates facilitate in vitro protein renaturation. Vuillard, L., Rabilloud, T., Goldberg, M.E. Eur. J. Biochem. (1998) [Pubmed]
  12. Improvement of the refolding yield and solubility of hen egg-white lysozyme by altering the Met residue attached to its N-terminus to Ser. Mine, S., Ueda, T., Hashimoto, Y., Imoto, T. Protein Eng. (1997) [Pubmed]
  13. Complete amino acid sequence of ostrich (Struthio camelus) egg-white lysozyme, a goose-type lysozyme. Schoentgen, F., Jollès, J., Jollès, P. Eur. J. Biochem. (1982) [Pubmed]
  14. Insect lysozyme from house fly (Musca domestica) larvae: possible digestive function based on sequence and enzymatic properties. Ito, Y., Nakamura, M., Hotani, T., Imoto, T. J. Biochem. (1995) [Pubmed]
  15. Site-specific 13C-labeling of Trp 62 in hen egg-white lysozyme: preparation and 13C-NMR titration of [delta 1-13C]Trp 62-lysozyme. Nakazawa, T., Sakiyama, F. J. Biochem. (1991) [Pubmed]
  16. Multiple mRNAs are generated from the chicken lysozyme gene. Grez, M., Land, H., Giesecke, K., Schütz, G., Jung, A., Sippel, A.E. Cell (1981) [Pubmed]
  17. Exons encode functional and structural units of chicken lysozyme. Jung, A., Sippel, A.E., Grez, M., Schütz, G. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  18. Lack of correlation between DNA methylation and transcriptional inactivation: the chicken lysozyme gene. Wölfl, S., Schräder, M., Wittig, B. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  19. Immunoadsorption of specific chicken oviduct polysomes. Isolation of ovalbumin, ovomucoid, and lysozyme messenger RNA. Groner, B., Hynes, N.E., Sippel, A.E., Jeep, S., Chi-Nguyen-Huu, M., Schütz, G. J. Biol. Chem. (1977) [Pubmed]
  20. Precursor of egg white lysozyme. Amino acid sequence of an NH2-terminal extension. Palmiter, R.D., Gagnon, J., Ericsson, L.H., Walsh, K.A. J. Biol. Chem. (1977) [Pubmed]
  21. A nuclear DNA attachment element mediates elevated and position-independent gene activity. Stief, A., Winter, D.M., Strätling, W.H., Sippel, A.E. Nature (1989) [Pubmed]
  22. Myb and NF-M: combinatorial activators of myeloid genes in heterologous cell types. Ness, S.A., Kowenz-Leutz, E., Casini, T., Graf, T., Leutz, A. Genes Dev. (1993) [Pubmed]
  23. Effect of immunotherapy with Corynebacterium parvum and methanol extraction residue of BCG administered intravenously on host defense function in cancer patients. Hersh, E.M., Murphy, S.G., Quesada, J.R., Gutterman, J.U., Gschwind, C.R., Morgan, J. J. Natl. Cancer Inst. (1981) [Pubmed]
  24. Structural and dynamical properties of a denatured protein. Heteronuclear 3D NMR experiments and theoretical simulations of lysozyme in 8 M urea. Schwalbe, H., Fiebig, K.M., Buck, M., Jones, J.A., Grimshaw, S.B., Spencer, A., Glaser, S.J., Smith, L.J., Dobson, C.M. Biochemistry (1997) [Pubmed]
  25. Conversion of Trp 62 of hen egg-white lysozyme to Tyr by site-directed mutagenesis. Kumagai, I., Kojima, S., Tamaki, E., Miura, K. J. Biochem. (1987) [Pubmed]
  26. Glucocorticoid and progesterone receptors bind to the same sites in two hormonally regulated promoters. von der Ahe, D., Janich, S., Scheidereit, C., Renkawitz, R., Schütz, G., Beato, M. Nature (1985) [Pubmed]
  27. Allergenicity and antigenicity of chicken egg ovomucoid (Gal d III) compared with ovalbumin (Gal d I) in children with egg allergy and in mice. Bernhisel-Broadbent, J., Dintzis, H.M., Dintzis, R.Z., Sampson, H.A. J. Allergy Clin. Immunol. (1994) [Pubmed]
  28. Isolation of recombinant plasmids bearing cDNA to hen ovomucoid and lysozyme mRNAs. Buell, G.N., Wickens, M.P., Carbon, J., Schimke, R.T. J. Biol. Chem. (1979) [Pubmed]
  29. An integrated process for purification of lysozyme, ovalbumin, and ovomucoid from hen egg white. Roy, I., Rao, M.V., Gupta, M.N. Appl. Biochem. Biotechnol. (2003) [Pubmed]
  30. Specific disulfide cleavage is required for ubiquitin conjugation and degradation of lysozyme. Dunten, R.L., Cohen, R.E., Gregori, L., Chau, V. J. Biol. Chem. (1991) [Pubmed]
  31. Inhalant allergy to egg yolk and egg white proteins. Quirce, S., Díez-Gómez, M.L., Eiras, P., Cuevas, M., Baz, G., Losada, E. Clin. Exp. Allergy (1998) [Pubmed]
  32. Effect of alkylation with different sized substituents on the conformation of ovomucoid, lysozyme and ovotransferrin. Fretheim, K., Egelandsdal, B., Harbitz, O. Int. J. Pept. Protein Res. (1985) [Pubmed]
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