Disease relevance of C06185

• Included in the review are slaframine; hydroxylated indolizidines and their analogues; alkaloids from ants and amphibians; metabolites of the genera Prosopis, Streptomyces and Nuphar and the Lythraceae; phenanthroindolizidines and related alkaloids; lupin alkaloids; and alkaloids from sponges. tunicates and coccinellid beetles [1].
• The extent to which slaframine and swainsonine mycotoxicosis pose threats to animal husbandry and, indeed, to humans, if these alkaloids were to enter the human food chain, deserves serious consideration [2].
• The effect of slaframine on salivary output and subacute and acute acidosis in growing beef steers [3].
• Slaframine administration induced hyperglycemia and hyperinsulinemia in goats; however, these changes were blocked by preadministration of isomolar quantities of the M3-muscarinic receptor antagonist, 4DAMP [4].

Psychiatry related information on C06185

• Estimating salivary flow and ruminal water balance of intake, diet, feeding pattern, and slaframine [5].

High impact information on C06185

• The fungal parasite Rhizoctonia leguminicola produces two indolizidine alkaloids, slaframine and swainsonine, of physiological interest [6].
• Mass spectrometric examination of the slaframine biosynthesized from cis- and trans-[1,3,3-2H]-1-hydroxyoctahydroindolizine strengthened arguments that 1-oxooctahydroindolizine is an intermediate in slaframine biogenesis [7].
• Toxic hay caused extreme salivation, piloerection, respiratory distress, and increased frequency of defecation when fed to guinea pigs, and purified extracts of toxic hay and pure slaframine elicited these same responses when injected intraperitoneally into guinea pigs [8].
• The derivatized slaframine was chromatographed isocratically using HPLC on a Hamilton PRP-1 C18 polymeric column with fluorescence detection [9].
• Influence of duodenal slaframine infusion on site of nutrient disappearance from the digestive tract of steers fed a high-concentrate diet [10].

Biological context of C06185

• Slaframine administration is generally associated with increased exocrine function, especially salivation [11].

Anatomical context of C06185

• Slaframine in a .9% saline excipient was infused into the duodenum every 12 h with total daily dose of 0, 30, 60, or 90 micrograms /kg of BW [10].

Associations of C06185 with other chemical compounds

• Swainsonine and slaframine are produced by Rhizoctonia leguminicola and cause mannose accumulation and parasympathomimetic effects, respectively [12].

Gene context of C06185

• The effect of daily slaframine injection of salivary score, feed intake, ruminal pH, and circulating concentrations of somatotropin and insulin-like growth factor I [13].
• The ability of slaframine (SF), a parasympathomimetic, to alter blood growth hormone (GH) and glucose concentrations in broiler chicks was investigated [14].

Analytical, diagnostic and therapeutic context of C06185

• Slaframine (1-acetoxy-6-amino-octahydroindolizine) was identified in purified extracts of toxic hay by gas-liquid chromatography-mass spectrometry after preparative thin-layer chromatography [8].
• New, sensitive high-performance liquid chromatography method for the determination of slaframine in plasma and milk [9].
• The effect of duodenal slaframine (SF) infusion on site and extent of digestion was determined using four steers equipped with ruminal, duodenal, and ileal cannulas in a 4 x 4 Latin square [10].

References