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Chemical Compound Review

Myosmine     3-(4,5-dihydro-3H-pyrrol-2- yl)pyridine

Synonyms: Prestwick_202, M8765_ALDRICH, AGN-PC-008TMI, CHEMBL423429, AG-F-82245, ...
 
 
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Disease relevance of Myosmine

  • Therefore, the metabolism of myosmine has been studied in Wistar rats treated with single oral doses of [pyridine-5-3H]myosmine at 0.001, 0.005, 0.5, and 50 micromol/kg body weight [1].
  • Therefore, the role of dietary myosmine in esophageal adenocarcinoma should be further investigated [2].
  • In conclusion, myosmine exerts significant genotoxic effects in esophageal cells under conditions which may prevail in GERD such as increased oxidative and nitrosative stress resulting from chronic inflammation [3].
 

Psychiatry related information on Myosmine

 

High impact information on Myosmine

 

Chemical compound and disease context of Myosmine

 

Biological context of Myosmine

 

Anatomical context of Myosmine

 

Analytical, diagnostic and therapeutic context of Myosmine

  • In the present study, possible genotoxic effects of myosmine were studied in human lymphocytes and nasal mucosal cells using the alkaline single cell microgel electrophoresis (Comet) assay [8].

References

  1. Metabolism of myosmine in Wistar rats. Zwickenpflug, W., Tyroller, S., Richter, E. Drug Metab. Dispos. (2005) [Pubmed]
  2. New sources of dietary myosmine uptake from cereals, fruits, vegetables, and milk. Tyroller, S., Zwickenpflug, W., Richter, E. J. Agric. Food Chem. (2002) [Pubmed]
  3. Genotoxic effects of myosmine in a human esophageal adenocarcinoma cell line. Vogt, S., Fuchs, K., Richter, E. Toxicology (2006) [Pubmed]
  4. Nitrosation of dietary myosmine as risk factor of human cancer. Wilp, J., Zwickenpflug, W., Richter, E. Food Chem. Toxicol. (2002) [Pubmed]
  5. Comprehensive analysis of urinary metabolites of N'-nitrosonornicotine. Hecht, S.S., Lin, D., Chen, C.B. Carcinogenesis (1981) [Pubmed]
  6. Investigation of the reaction of myosmine with sodium nitrite in vitro and in rats. Hecht, S.S., Han, S., Kenney, P.M., Wang, M., Lindgren, B., Wang, Y., Lao, Y., Hochalter, J.B., Upadhyaya, P. Chem. Res. Toxicol. (2007) [Pubmed]
  7. Acute and subacute effects of tobacco alkaloids, tobacco-specific nitrosamines and phenethyl isothiocyanate on N'-nitrosonornicotine metabolism in rats. Tyroller, S., Zwickenpflug, W., Thalheim, C., Richter, E. Toxicology (2005) [Pubmed]
  8. Genotoxic effects of myosmine in human lymphocytes and upper aerodigestive tract epithelial cells. Kleinsasser, N.H., Wallner, B.C., Harréus, U.A., Zwickenpflug, W., Richter, E. Toxicology (2003) [Pubmed]
  9. Unifying mechanism for toxicity and addiction by abused drugs: electron transfer and reactive oxygen species. Kovacic, P., Cooksy, A.L. Med. Hypotheses (2005) [Pubmed]
 
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