The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Anplag     4-[1-dimethylamino-3-[2-[2- (3...

Synonyms: PubChem18207, Anplag (TN), CHEMBL541829, SureCN120568, Bio-0144, ...
This record was replaced with 5160.
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Sarpogrelate


High impact information on Sarpogrelate

  • The inductions of TF and PAI-1 mRNAs were inhibited by a 5-HT1/5-HT2 receptor antagonist (methiothepin) and a selective 5-HT2A receptor antagonist (MCI-9042) [5].
  • These results suggest that MCI-9042 is a selective S2-serotonergic receptor antagonist, exhibiting the inhibition of S2-serotonergic potentiated platelet aggregation and the suppression of blood vessel constriction mediated by S2-serotonergic receptor [6].
  • The neuroprotective effect of MCI-9042 (Mitsubishi Pharma Corporation) was investigated on glutamate-induced retinal ganglion cell (RGC) death in vitro and on rat retinal ischemia in vivo [2].
  • Treatment with MCI-9042 significantly inhibited the development of MCT-PH along with a decrease in the number of PCNA-positive cells, suggesting a pivotal role of serotonin in the development of PH induced by MCT [7].
  • The severity of PH as determined by the medial thickness of the small pulmonary arteries and RV/(LV + S) weight ratio in rats with MCT-PH was significantly reduced after treatment with MCI-9042 (p < 0.01 and p < 0.05, respectively) [7].

Biological context of Sarpogrelate

  • We conclude that the binding site of [3H]haloperidol in the rat striatum is the D2 receptor, that MCI-9042 and its metabolite have lower affinities for D2 receptors than for 5-HT2 receptors, and that this radioreceptor assay is useful for assessing the affinities of various agents [8].

Anatomical context of Sarpogrelate

  • These results suggest that serotonin which may be released from platelets of DM patients may activate platelets together with collagen exposed on atherosclerotic endothelium and that MCI-9042 may be inhibitory to enhanced platelet aggregability under these conditions [9].
  • After injection of antiglomerular basement membrane antiserum, urinary protein excretion was significantly decreased in rats treated with the serotonin receptor antagonist, MCI-9042, and in rats treated with p-chlorophenylalanine [10].
  • The present study was designed to examine 1) the properties of [3H]ketanserin binding to serotonin-2 (5HT2)-serotonergic receptors in the rabbit platelet membranes, 2) displacement affinities of various chemicals and 3) difference of the affinities between their chemicals and new agents, MCI-9042 and M-1 [11].
  • In conclusion, anplag significantly reduced IH after balloon injury in the hypercholesterolaemic rabbit by inhibiting proliferation of smooth muscle cells and cholesterol-uptake by macrophages when it was administered immediately before the procedure [12].

Gene context of Sarpogrelate

  • The number of PCNA-positive cells was significantly greater in MCT-PH rats than in normal control rats (p < 0.0001) and was reduced after treatment with MCI-9042 (p < 0.0001) [7].

Analytical, diagnostic and therapeutic context of Sarpogrelate

  • In mesenteric arterial thrombosis induced by electric stimulation in mice, MCI-9042 prolonged the occlusion time resulted from platelet thrombus formation (PD50: 23 mg/kg po) [1].
  • The scores for histopathologic changes, such as thickening of the alveolar walls and interstitial inflammatory cell infiltration in MCT-PH rats, were significantly reduced after treatment with MCI-9042 (p < 0.05 and p < 0.01, respectively) [7].


  1. Antithrombotic effect of MCI-9042, a new antiplatelet agent on experimental thrombosis models. Hara, H., Kitajima, A., Shimada, H., Tamao, Y. Thromb. Haemost. (1991) [Pubmed]
  2. Effect of MCI-9042, a 5-HT2 receptor antagonist, on retinal ganglion cell death and retinal ischemia. Inoue-Matsuhisa, E., Sogo, S., Mizota, A., Taniai, M., Takenaka, H., Mano, T. Exp. Eye Res. (2003) [Pubmed]
  3. Sarpogrelate, a 5-hT2A receptor antagonist in intermittent claudication. A phase II european study. Norgren, L., Jawien, A., Mátyás, L., Riegerd, H., Arita, K. Vascular medicine (London, England) (2006) [Pubmed]
  4. The effect of a 5HT2 receptor antagonist sarpogrelate (MCI-9042) treatment on platelet function in Buerger's disease. Rydzewski, A., Urano, T., Hachiya, T., Kaneko, H., Baba, S., Takada, Y., Takada, A. Thromb. Res. (1996) [Pubmed]
  5. Serotonin induces the expression of tissue factor and plasminogen activator inhibitor-1 in cultured rat aortic endothelial cells. Kawano, H., Tsuji, H., Nishimura, H., Kimura, S., Yano, S., Ukimura, N., Kunieda, Y., Yoshizumi, M., Sugano, T., Nakagawa, K., Masuda, H., Sawada, S., Nakagawa, M. Blood (2001) [Pubmed]
  6. MCI-9042, a new antiplatelet agent is a selective S2-serotonergic receptor antagonist. Hara, H., Osakabe, M., Kitajima, A., Tamao, Y., Kikumoto, R. Thromb. Haemost. (1991) [Pubmed]
  7. Development of monocrotaline-induced pulmonary hypertension is attenuated by a serotonin receptor antagonist. Miyata, M., Ito, M., Sasajima, T., Ohira, H., Sato, Y., Kasukawa, R. Lung (2000) [Pubmed]
  8. Binding of [3H]haloperidol to dopamine D2 receptors in the rat striatum. Tsuchihashi, H., Sasaki, T., Kojima, S., Nagatomo, T. J. Pharm. Pharmacol. (1992) [Pubmed]
  9. The effect of MCI-9042 on serotonin-induced platelet aggregation in type 2 diabetes mellitus. Pietraszek, M.H., Takada, Y., Taminato, A., Yoshimi, T., Watanabe, I., Takada, A. Thromb. Res. (1993) [Pubmed]
  10. Role of serotonin in nephrotoxic serum nephritis in WKY rats. Kanai, H., Hiromura, K., Kuroiwa, T., Maezawa, A., Yano, S., Naruse, T. J. Lab. Clin. Med. (1997) [Pubmed]
  11. Binding characteristics of [3H]ketanserin for serotonin-2 receptor in the rabbit platelet. Tsuchihashi, H., Yagi, N., Kimura, M., Shirota, K., Kinami, J., Nagatomo, T. J. Pharmacobio-dyn. (1991) [Pubmed]
  12. Anplag, a selective 5-HT2 receptor antagonist, reduces stenosis induced by balloon injury in the hypercholesterolaemic rabbit. Origuchi, N., Shigematsu, H., Muto, T. International angiology : a journal of the International Union of Angiology. (1997) [Pubmed]
WikiGenes - Universities