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Gene Review

WNT10B  -  wingless-type MMTV integration site family...

Homo sapiens

Synonyms: Protein Wnt-10b, Protein Wnt-12, SHFM6, WNT-12, WNT12
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Disease relevance of WNT10B


High impact information on WNT10B


Chemical compound and disease context of WNT10B


Biological context of WNT10B


Anatomical context of WNT10B

  • The expression pattern of WNT10B reveals that it is synthesized in many adult tissues with the highest levels found in heart and skeletal muscle [7].
  • WNT10B might be implicated in self renewal of stem cells as well as in carcinogenesis through activation of the WNT - beta-catenin pathway [3].
  • To investigate if estrogen and these four pyrethroid insecticides could affect the expression of a gene related to mammary gland development, WNT10B expression in pyrethroid-treated MCF-7 cells was examined [6].

Associations of WNT10B with chemical compounds


Regulatory relationships of WNT10B


Analytical, diagnostic and therapeutic context of WNT10B


  1. Proto-oncogene WNT10B is up-regulated by tumor necrosis factor alpha in human gastric cancer cell line MKN45. Saitoh, T., Kirikoshi, H., Mine, T., Katoh, M. Int. J. Oncol. (2001) [Pubmed]
  2. A novel human Wnt gene, WNT10B, maps to 12q13 and is expressed in human breast carcinomas. Bui, T.D., Rankin, J., Smith, K., Huguet, E.L., Ruben, S., Strachan, T., Harris, A.L., Lindsay, S. Oncogene (1997) [Pubmed]
  3. Expression and regulation of WNT10B in human cancer: up-regulation of WNT10B in MCF-7 cells by beta-estradiol and down-regulation of WNT10B in NT2 cells by retinoic acid. Kirikoshi, H., Katoh, M. Int. J. Mol. Med. (2002) [Pubmed]
  4. Differential expression of WNTs and FRPs in the synovium of rheumatoid arthritis and osteoarthritis. Imai, K., Morikawa, M., D'Armiento, J., Matsumoto, H., Komiya, K., Okada, Y. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  5. WNT10A and WNT6, clustered in human chromosome 2q35 region with head-to-tail manner, are strongly coexpressed in SW480 cells. Kirikoshi, H., Sekihara, H., Katoh, M. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  6. Effects of pyrethroid insecticides and estrogen on WNT10B proto-oncogene expression. Kasat, K., Go, V., Pogo, B.G. Environment international. (2002) [Pubmed]
  7. Isolation, characterization and chromosomal localization of human WNT10B. Hardiman, G., Kastelein, R.A., Bazan, J.F. Cytogenet. Cell Genet. (1997) [Pubmed]
  8. Enhanced SMYD3 expression is essential for the growth of breast cancer cells. Hamamoto, R., Silva, F.P., Tsuge, M., Nishidate, T., Katagiri, T., Nakamura, Y., Furukawa, Y. Cancer Sci. (2006) [Pubmed]
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