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Chemical Compound Review

deamido-NAD+     1-[(3R,4S,5R)-5- [[[[(2R,3S,4R,5R)-5-(6...

Synonyms: AC1NRAU2, DND
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Disease relevance of Nicotinic acid adenine dinucleotide

  • In addition, the E. coli NADS structures revealed unexpected dynamical rearrangements in the NAAD/NAD binding pocket upon NAAD-to-NAD conversion, which define a catalysis state and a substrate/product exchange state [1].

High impact information on Nicotinic acid adenine dinucleotide


Biological context of Nicotinic acid adenine dinucleotide


Anatomical context of Nicotinic acid adenine dinucleotide


Associations of Nicotinic acid adenine dinucleotide with other chemical compounds


Analytical, diagnostic and therapeutic context of Nicotinic acid adenine dinucleotide


  1. Structures of Escherichia coli NAD synthetase with substrates and products reveal mechanistic rearrangements. Jauch, R., Humm, A., Huber, R., Wahl, M.C. J. Biol. Chem. (2005) [Pubmed]
  2. Nicotinic acid adenine dinucleotide phosphate (NAADP(+)) is an essential regulator of T-lymphocyte Ca(2+)-signaling. Berg, I., Potter, B.V., Mayr, G.W., Guse, A.H. J. Cell Biol. (2000) [Pubmed]
  3. Calcium release from the endoplasmic reticulum of higher plants elicited by the NADP metabolite nicotinic acid adenine dinucleotide phosphate. Navazio, L., Bewell, M.A., Siddiqua, A., Dickinson, G.D., Galione, A., Sanders, D. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  4. Second messenger function of nicotinic acid adenine dinucleotide phosphate revealed by an improved enzymatic cycling assay. Gasser, A., Bruhn, S., Guse, A.H. J. Biol. Chem. (2006) [Pubmed]
  5. Nicotinic acid adenine dinucleotide phosphate potentiates neurite outgrowth. Brailoiu, E., Hoard, J.L., Filipeanu, C.M., Brailoiu, G.C., Dun, S.L., Patel, S., Dun, N.J. J. Biol. Chem. (2005) [Pubmed]
  6. Extracellular application of nicotinic acid adenine dinucleotide phosphate induces Ca2+ signaling in astrocytes in situ. Heidemann, A.C., Schipke, C.G., Kettenmann, H. J. Biol. Chem. (2005) [Pubmed]
  7. Lysosome-sarcoplasmic reticulum junctions. A trigger zone for calcium signaling by nicotinic acid adenine dinucleotide phosphate and endothelin-1. Kinnear, N.P., Boittin, F.X., Thomas, J.M., Galione, A., Evans, A.M. J. Biol. Chem. (2004) [Pubmed]
  8. Widespread distribution of binding sites for the novel Ca2+-mobilizing messenger, nicotinic acid adenine dinucleotide phosphate, in the brain. Patel, S., Churchill, G.C., Sharp, T., Galione, A. J. Biol. Chem. (2000) [Pubmed]
  9. Nicotinic acid adenine dinucleotide phosphate enhances quantal neurosecretion at the frog neuromuscular junction: possible action on synaptic vesicles in the releasable pool. Brailoiu, E., Miyamoto, M.D., Dun, N.J. Mol. Pharmacol. (2001) [Pubmed]
  10. Structural gene for NAD synthetase in Salmonella typhimurium. Hughes, K.T., Olivera, B.M., Roth, J.R. J. Bacteriol. (1988) [Pubmed]
  11. Nicotinic acid adenine dinucleotide phosphate triggers Ca2+ release from brain microsomes. Bak, J., White, P., Timár, G., Missiaen, L., Genazzani, A.A., Galione, A. Curr. Biol. (1999) [Pubmed]
  12. Ryanodine receptor type I and nicotinic acid adenine dinucleotide phosphate receptors mediate Ca2+ release from insulin-containing vesicles in living pancreatic beta-cells (MIN6). Mitchell, K.J., Lai, F.A., Rutter, G.A. J. Biol. Chem. (2003) [Pubmed]
  13. Identification of the enzymatic active site of CD38 by site-directed mutagenesis. Munshi, C., Aarhus, R., Graeff, R., Walseth, T.F., Levitt, D., Lee, H.C. J. Biol. Chem. (2000) [Pubmed]
  14. Nicotinic acid-adenine dinucleotide phosphate activates the skeletal muscle ryanodine receptor. Hohenegger, M., Suko, J., Gscheidlinger, R., Drobny, H., Zidar, A. Biochem. J. (2002) [Pubmed]
  15. Nicotinic acid adenine dinucleotide phosphate mediates Ca2+ signals and contraction in arterial smooth muscle via a two-pool mechanism. Boittin, F.X., Galione, A., Evans, A.M. Circ. Res. (2002) [Pubmed]
  16. Niacin and carcinogenesis. Kirkland, J.B. Nutrition and cancer. (2003) [Pubmed]
  17. Regulation of calcium signalling by adenine-based second messengers. Fliegert, R., Gasser, A., Guse, A.H. Biochem. Soc. Trans. (2007) [Pubmed]
  18. Metabolism of the novel Ca2+-mobilizing messenger nicotinic acid-adenine dinucleotide phosphate via a 2'-specific Ca2+-dependent phosphatase. Berridge, G., Cramer, R., Galione, A., Patel, S. Biochem. J. (2002) [Pubmed]
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