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Chemical Compound Review

Barnetil     N-[(1-ethylpyrrolidin-2- yl)methyl]-5...

Synonyms: Barnotil, Sultopride, Topral, Sultopridum, Sultroprida, ...
 
 
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Disease relevance of Sultopride

  • The effects of MS-377 on haloperidol- or sultopride-induced inhibition of apomorphine-induced climbing behavior and catalepsy were investigated in mice and rats, respectively [1].
  • With high doses, decrease of specificity for subclasses of DA receptors, central DA inhibition, antihallucinatory effects but little extrapyramidal symptomatology and sedation. sultopride: central DA inhibition, antihallucinatory effects, sedative and neurological effects [2].
 

Psychiatry related information on Sultopride

 

High impact information on Sultopride

 

Biological context of Sultopride

 

Anatomical context of Sultopride

 

Associations of Sultopride with other chemical compounds

 

Gene context of Sultopride

 

Analytical, diagnostic and therapeutic context of Sultopride

References

  1. Effects of sigma(1) receptor ligand MS-377 on D(2) antagonists-induced behaviors. Karasawa, J., Takahashi, S., Takagi, K., Horikomi, K. Pharmacol. Biochem. Behav. (2002) [Pubmed]
  2. Pharmacological classification of benzamides. Puech, A.J., Lecrubier, Y., Simon, P. Acta psychiatrica Scandinavica. Supplementum. (1984) [Pubmed]
  3. Akathisia, motility, and locomotion in healthy volunteers. Blin, O., Durup, M., Pailhous, J., Serratrice, G. Clinical neuropharmacology. (1990) [Pubmed]
  4. 2-Phenylpyrroles as conformationally restricted benzamide analogues. A new class of potential antipsychotics. 1. van Wijngaarden, I., Kruse, C.G., van Hes, R., van der Heyden, J.A., Tulp, M.T. J. Med. Chem. (1987) [Pubmed]
  5. Effects of chronic sultopride treatment on endocrine systems in psychotic women. Miyachi, Y., Mizuchi, A., Hamano, H., Sarai, K. Psychopharmacology (Berl.) (1984) [Pubmed]
  6. Regional distribution of sultopride and sulpiride in rat brain measured by radioimmunoassay. Mizuchi, A., Kitagawa, N., Miyachi, Y. Psychopharmacology (Berl.) (1983) [Pubmed]
  7. The antipsychotic sultopride is overdosed - a PET study of drug-induced receptor occupancy in comparison with sulpiride. Takano, A., Suhara, T., Yasuno, F., Suzuki, K., Takahashi, H., Morimoto, T., Lee, Y.J., Kusuhara, H., Sugiyama, Y., Okubo, Y. Int. J. Neuropsychopharmacol. (2006) [Pubmed]
  8. Characteristics of [3H]sultopride binding to rat brain. Mizuchi, A., Kitagawa, N., Saruta, S., Miyachi, Y. Eur. J. Pharmacol. (1982) [Pubmed]
  9. Biotransformation of sultopride in man and several animal species. Kobari, T., Namekawa, H., Kato, Y., Yamada, S. Xenobiotica (1985) [Pubmed]
  10. Disposition of enantiomers of sultopride in a human, rats and rabbits. Kamizono, A., Inotsume, N., Fukushima, S., Nakano, M. Biol. Pharm. Bull. (1993) [Pubmed]
  11. Pharmacological analysis of the effects of substituted benzamides on the isolated guinea-pig ileum. Study of metoclopramide, sulpiride, bromopride, tiapride and sultopride. Fontaine, J., Reuse, J. Archives internationales de pharmacodynamie et de thérapie. (1978) [Pubmed]
  12. Determination of sultopride and tiapride in serum by gas chromatography using a surface ionisation detector. Kamizono, A., Inotsume, N., Miyamoto, K., Ueda, K., Miyakawa, T., Arimoto, H., Nakano, M. J. Chromatogr. (1991) [Pubmed]
  13. Binding study of benzamides to serum albumins by fluorescence probe technique. Denisoff, O., Molle, L. Arzneimittel-Forschung. (1978) [Pubmed]
  14. Effect of sultopride on prolactin secretion in rats. Mizuchi, A., Kitagawa, N., Saruta, S., Tokuda, H., Miyachi, Y. Archives internationales de pharmacodynamie et de thérapie. (1984) [Pubmed]
  15. Establishment of enzyme immunoassay for measuring serum sultopride levels. Someya, T., Shimoda, K., Muratake, T., Nakajima, E., Shirai, A., Funaoka, H., Yashiki, T., Ishii, H., Sunahara, N., Takahashi, S. Therapeutic drug monitoring. (2001) [Pubmed]
  16. Determination of sultopride in serum and saliva by high-performance liquid chromatography. Nishihara, K., Kohda, Y., Tamura, Z. Chem. Pharm. Bull. (1983) [Pubmed]
  17. Absorption, distribution and excretion of sultopride in man and several animal species. Kobari, T., Iguro, Y., Ito, T., Namekawa, H., Kato, Y., Yamada, S. Xenobiotica (1985) [Pubmed]
 
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