The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

FK-224     N-[(18Z)-6- (aminocarbonylmethyl)-12- benzyl...

Synonyms: AC1O5OJO, FK 224, L003301
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of FK 224

 

High impact information on FK 224

 

Biological context of FK 224

  • The effect of FK224 (N-(N2-[N-¿N-(N-2,3-didehydro-N-methyl-N-[N-3- (2-pentylphenyl)-propionyl¿-L-threonyl]tyrosyl-L-leucynyl)-D -phenylalanyl¿-L-allothreonyl]-L-asparaginyl)-L-serine-v-lacto ne, CAS 125787-94-2) on isometric contraction of canine tracheal smooth muscle in situ was studied [4].
 

Anatomical context of FK 224

  • Neutrophils in BAL fluid did not significantly increase after ozone exposure in animals treated with FK-224 [1].
 

Associations of FK 224 with other chemical compounds

 

Gene context of FK 224

  • In the presence of FK 224, SP dose-response curves and NKA dose-response curves were shifted to the right in parallel with no depression of the maximal contraction.(ABSTRACT TRUNCATED AT 250 WORDS)[3]
 

Analytical, diagnostic and therapeutic context of FK 224

References

  1. The effects of a specific tachykinin receptor antagonist FK-224 on ozone-induced airway hyperresponsiveness and inflammation. Aizawa, H., Koto, H., Nakano, H., Inoue, H., Matsumoto, K., Takata, S., Shigyo, M., Hara, N. Respirology (1997) [Pubmed]
  2. Protection against bradykinin-induced bronchoconstriction in asthmatic patients by neurokinin receptor antagonist. Ichinose, M., Nakajima, N., Takahashi, T., Yamauchi, H., Inoue, H., Takishima, T. Lancet (1992) [Pubmed]
  3. FK 224, a novel cyclopeptide substance P antagonist with NK1 and NK2 receptor selectivity. Morimoto, H., Murai, M., Maeda, Y., Yamaoka, M., Nishikawa, M., Kiyotoh, S., Fujii, T. J. Pharmacol. Exp. Ther. (1992) [Pubmed]
  4. Effect of a new dual neurokinin antagonist on airway smooth muscle in situ. Shioya, T., Kagaya, M., Sano, M., Itaba, M., Shindo, T., Fujii, T., Miura, M. Arzneimittel-Forschung. (1995) [Pubmed]
  5. The effect of the neurokinin antagonist FK-224 on the cough response to inhaled capsaicin in a new model of guinea-pig eosinophilic bronchitis induced by intranasal polymyxin B. Ogawa, H., Fujimura, M., Saito, M., Matsuda, T., Akao, N., Kondo, K. Clin. Auton. Res. (1994) [Pubmed]
 
WikiGenes - Universities