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Chemical Compound Review:

CCRIS 7132 ethyl(2E,4E,6E,8E,10E,12E)- docosa-2,4,6,8...

Synonyms: AC1O5T30, Docosahexaenoic acid, ethyl ester

Du, C. et al., Cao, D. et al., Cao, D.H. et al., Miyazaki, M. et al., Glozman, S. et al., et al.

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Disease relevance of Ethyl docosahexaenoate

Studies were conducted on the prenatal rat given a single intraamniotic injection of ethyl docosahexaenoate (Et-DHA; 9.6-12 mmol per fetus) or subjected to an n-3 fatty acid-deficient diet to assess the role of docosahexaenoate on oxidative stress during episodes of ischemia [1].
Protective effect of chronic ethyl docosahexaenoate administration on brain injury in ischemic gerbils [2].
Chronic administration of ethyl docosahexaenoate decreases mortality and cerebral edema in ischemic gerbils [3].
In the present study, the protective effect of chronic administration of ethyl docosahexaenoate (E-DHA) against oxidative brain injury was evaluated in the gerbil model of transient cerebral ischemia [2].

High impact information on Ethyl docosahexaenoate

Fetal rats at 17 days of gestation were injected intraamniotically with ethyl docosahexaenoate (EtDHA) [4].
Single intraamniotic injections of 5 microL ethyl-docosahexaenoate (Et-DHA) (12 microM, 4.25 mg) administered to 17-day-old fetuses were used to examine the uptake of DHA into brain PL [5].
Platelet aggregation induced by N2 microbubbles (simulating microbubbles developed during deep diving) was measured in seven volunteers before and after intake of ethyl-eicosapentaenoate (-EPA, 3.5 g/day) and ethyl-docosahexaenoate (-DHA, 2.5 g/day) for 2 wk [6].
Chronic administration of ethyl docosahexaenoate reduces gerbil brain eicosanoid productions following ischemia and reperfusion [7].
Therefore, in the present study, we investigated the effects of chronic ethyl docosahexaenoate (E-DHA) administration on mortality and cerebral edema induced by transient forebrain ischemia in gerbils [3].

Biological context of Ethyl docosahexaenoate

Previously we have shown that intraamniotic administration of ethyl docosahexaenoate (Et-DHA) to pregnant rats resulted in decreased lipid peroxidation in the fetal brain, under a variety of conditions (S. Glozman, P. Green, E. Yavin, J. Neurochem. 70 (1998) 2482-2491) [8].

Associations of Ethyl docosahexaenoate with other chemical compounds

We have noted that n-3 fatty acid-rich oils, such as fish oil, perilla oil and flaxseed oil as well as ethyl docosahexaenoate (DHA) prolonged the survival time of stroke-prone spontaneously hypertensive rats (SHRSP) rats by approximately 10% as compared with linoleate (n-6)-rich safflower oil [9].

Gene context of Ethyl docosahexaenoate

To define the long-term effects of fats and oils in more detail, female mice were fed a conventional basal diet supplemented with lard (Lar), high-linoleic (n-6) safflower oil (Saf), rapeseed oil (Rap), high-alpha-linolenic (n-3) perilla oil (Per), or a mixture of ethyl docosahexaenoate and soybean oil (DHA/Soy) from 17 weeks to 71 weeks of age [10].

Analytical, diagnostic and therapeutic context of Ethyl docosahexaenoate

Enhanced free radical scavenging and decreased lipid peroxidation in the rat fetal brain after treatment with ethyl docosahexaenoate [11].

References

Intraamniotic ethyl docosahexaenoate administration protects fetal rat brain from ischemic stress. Glozman, S., Green, P., Yavin, E. J. Neurochem. (1998) [Pubmed]
Protective effect of chronic ethyl docosahexaenoate administration on brain injury in ischemic gerbils. Cao, D.H., Xu, J.F., Xue, R.H., Zheng, W.F., Liu, Z.L. Pharmacol. Biochem. Behav. (2004) [Pubmed]
Chronic administration of ethyl docosahexaenoate decreases mortality and cerebral edema in ischemic gerbils. Cao, D., Li, M., Xue, R., Zheng, W., Liu, Z., Wang, X. Life Sci. (2005) [Pubmed]
Modulation of fetal rat brain and liver phospholipid content by intraamniotic ethyl docosahexaenoate administration. Green, P., Yavin, E. J. Neurochem. (1995) [Pubmed]
Natural and accelerated docosahexaenoic acid accumulation in the prenatal rat brain. Green, P., Yavin, E. Lipids (1996) [Pubmed]
Fatty acids in human platelets and plasma. Fish oils decrease sensitivity toward N2 microbubbles. Bakken, A.M., Farstad, M., Holmsen, H. J. Appl. Physiol. (1991) [Pubmed]
Chronic administration of ethyl docosahexaenoate reduces gerbil brain eicosanoid productions following ischemia and reperfusion. Cao, D., Zhou, C., Sun, L., Xue, R., Xu, J., Liu, Z. J. Nutr. Biochem. (2006) [Pubmed]
Ethyl docosahexaenoate-associated decrease in fetal brain lipid peroxide production is mediated by activation of prostanoid and nitric oxide pathways. Green, P., Glozman, S., Yavin, E. Biochim. Biophys. Acta (2001) [Pubmed]
Dietary docosahexaenoic acid ameliorates, but rapeseed oil and safflower oil accelerate renal injury in stroke-prone spontaneously hypertensive rats as compared with soybean oil, which is associated with expression for renal transforming growth factor-beta, fibronectin and renin. Miyazaki, M., Takemura, N., Watanabe, S., Hata, N., Misawa, Y., Okuyama, H. Biochim. Biophys. Acta (2000) [Pubmed]
Cholesterol synthesis in mice is suppressed but lipofuscin formation is not affected by long-term feeding of n-3 fatty acid-enriched oils compared with lard and n-6 fatty acid-enriched oils. Du, C., Sato, A., Watanabe, S., Wu, C.Z., Ikemoto, A., Ando, K., Kikugawa, K., Fujii, Y., Okuyama, H. Biol. Pharm. Bull. (2003) [Pubmed]
Enhanced free radical scavenging and decreased lipid peroxidation in the rat fetal brain after treatment with ethyl docosahexaenoate. Green, P., Glozman, S., Weiner, L., Yavin, E. Biochim. Biophys. Acta (2001) [Pubmed]

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