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Chemical Compound Review

BROMTHYMOL BLUE     2-bromo-4-[9-(3-bromo-4- hydroxy-2-methyl-5...

Synonyms: S-dioxide, NSC-7819, NSC7819, AC1Q1OGA, AC-12375, ...
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Disease relevance of Bromothymol blue

  • Inhibition of Escherichia coli serotype O157:H7 by bromthymol blue [1].
  • A total of 756 strains representing 17 Neisseria spp. and Branhamella catarrhalis were tested in this medium, in which the protein concentration was reduced relative to the carbohydrate concentration, phenol red was substituted for bromthymol blue at a low concentration, and the initial pH was adjusted to 7 [2].
  • Rats were immunized intraperitoneally with ovalbumin and the disappearance of bromthymol blue (BTB) from the intestinal lumen, its accumulation in the tissue, and its net absorption were examined by means of an in-situ recirculation technique during local anaphylaxis [3].

High impact information on Bromothymol blue


Anatomical context of Bromothymol blue


Associations of Bromothymol blue with other chemical compounds

  • Although the pH change indicated by the absorbance change was opposite to the light-induced pH change of the medium, the effect of KCl on the absorbance changes of BTB and NR, and the effect of valinomycin on that of NR, but not on that of BTB, were similar to those on the light-induced pH change [10].
  • Phenol red and Bromthymol blue record an alkalinization and an acidification, respectively, indicating that while the hydrophilic pH indicator faces an external domain, the hydrophobic pH indicator faces, at least partly, an internal domain [9].
  • We compared the kit results with those obtained by pH determination (nitrazine, bromthymol blue test) and measurement of AFP concentrations by enzyme-linked immunoassay (EIA) [11].

Analytical, diagnostic and therapeutic context of Bromothymol blue

  • Hemocyanin showed a simple hyperbolic binding curve in the bromthymol blue titration, whereas the time course of the reaction was generally biphasic [12].


  1. Inhibition of Escherichia coli serotype O157:H7 by bromthymol blue. Gubash, S.M., Anand, C.M., Stokman, M. J. Clin. Microbiol. (1988) [Pubmed]
  2. Modified oxidation-fermentation medium for detection of acid production from carbohydrates by Neisseria spp. and Branhamella catarrhalis. Knapp, J.S., Holmes, K.K. J. Clin. Microbiol. (1983) [Pubmed]
  3. Immunological control of drug absorption from the gastrointestinal tract: the mechanism whereby intestinal anaphylaxis interferes with the intestinal absorption of bromthymol blue in the rat. Yamamoto, A., Utsumi, E., Sakane, T., Hamaura, T., Nakamura, J., Hashida, M., Sezaki, H. J. Pharm. Pharmacol. (1986) [Pubmed]
  4. Effect of phospholipase A on the structure and functions of membrane vesicles from Mycobacterium phlei. Prasad, R., Kalra, V.K., Brodie, A.F. J. Biol. Chem. (1975) [Pubmed]
  5. Penicillinase-based enzyme-linked immunosorbent assay for the detection of plant viruses. Sudarshana, M.R., Reddy, D.V. J. Virol. Methods (1989) [Pubmed]
  6. Factors affecting the efflux of paraquat from rat lung slices. Smith, L.L., Wyatt, I., Rose, M.S. Toxicology (1981) [Pubmed]
  7. Stabilization of bromthymol blue colour in lecithin-sphingomyelin ratio determinations in amniotic fluid. Andrews, A.G., Horacek, I., Betheras, F.R. J. Clin. Pathol. (1976) [Pubmed]
  8. Intracellular pH measurements in gastric mucosa. Hersey, S.J. Am. J. Physiol. (1979) [Pubmed]
  9. Tracking of proton flow during transition from anaerobiosis to steady state in rat liver mitochondria. Luvisetto, S., Cola, C., Conover, T.E., Azzone, G.F. Biochim. Biophys. Acta (1990) [Pubmed]
  10. Light-induced pH changes and changes in absorbance of pH indicators in Rhodospirillum rubrum chromatophores. Nishi, N., Sakata-Sogawa, K., Soe, G., Yamashita, J. J. Biochem. (1977) [Pubmed]
  11. Rapid diagnosis of premature rupture of membranes using a new kit employing anti-AFP monoclonal antibody. Yamada, H., Fujimoto, S. Arch. Gynecol. Obstet. (1995) [Pubmed]
  12. An oxygenation-linked dye binding to Limulus polyphemus hemocyanin. Makino, N. Eur. J. Biochem. (1985) [Pubmed]
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