Disease relevance of Naphtholate AS

• Acute contact dermatitis from Naphthol AS [1].
• Clothing dermatitis from Naphthol AS [2].
• Naphthol AS, a coupling agent in cotton dyeing, caused allergic contact dermatitis in 5 patients, sensitized from wearing a special kind of shirt [3].

High impact information on Naphtholate AS

• Naphtol AS D chloroacetoesterase is associated with OKM 1 positivity in neoplastic myeloid cells [4].
• MC were stained for naphthol-AS/D-chloroacetate esterase and counted as MC per bile ductule [5].
• However, the lipid-gel accumulated about twice as much naphthol as the adipocytes, suggesting that hydrophobicity/hydrophilicity of the metabolite may be an important factor in the accuracy of accumulation studies with the lipid-gel [6].
• Naphthol AS enzyme substrates were loaded onto filter membranes by evaporation from an organic solvent [7].
• For cytochemical identification, naphthol AS acetate esterase staining was used for macrophages and peroxidase for granulocytes [8].

Biological context of Naphtholate AS

• This paper describes how fluorogenic substrates derived from naphthol AS can be used for the microscopic demonstration and cytofluorometric quantification of the activity and reaction kinetics of acid phosphatase in single living cells [9].
• The diagnoses were confirmed by the use of electron microscopy and cytochemistry (acid phosphatase and naphthol-AS-acetate-esterase) [10].

Anatomical context of Naphtholate AS

• (1) Simple esterase activity has been demonstrated in the gustatory epithelium of man and dog by the simultaneous coupling azo dye technique using alpha-naphthol and naphthol As acetate [11].

Associations of Naphtholate AS with other chemical compounds

• The malignant cells carried the cytological markers typical for the monocyte-macrophage series, e.g., acid phosphatase, NaF-sensitive naphthol-AS-acetate esterase, acid alpha-naphthyl-acetate esterase, lysozyme, and also Fc-IgG-receptors and mouse C3-receptors [12].

Gene context of Naphtholate AS

• Study of the enzymatic activity of H. pylori isolates showed that all isolates had urease, catalase, oxidase, esterase-lipase, and naphthol-AS-beta-1-phosphohydrolase enzymes and were consistently negative for ten other enzymes tested [13].

Analytical, diagnostic and therapeutic context of Naphtholate AS

• Patch tests with Naphthol AS and pieces of shirt were positive in all 5 patients [3].

References