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Chemical Compound Review

Methional     3-methylsulfanylpropanal

Synonyms: CHEMBL333298, CPD-7036, ACMC-1CO89, CCRIS 8434, AG-C-91596, ...
 
 
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Disease relevance of Methional

 

High impact information on Methional

 

Chemical compound and disease context of Methional

 

Biological context of Methional

 

Anatomical context of Methional

 

Associations of Methional with other chemical compounds

 

Gene context of Methional

 

Analytical, diagnostic and therapeutic context of Methional

References

  1. Peptide aldehyde inhibitors of bacterial peptide deformylases. Durand, D.J., Gordon Green, B., O'Connell, J.F., Grant, S.K. Arch. Biochem. Biophys. (1999) [Pubmed]
  2. Developmental toxicity study with 3-(methylthio)propionaldehyde vapor by whole-body exposure of Sprague-Dawley rats. Ballantyne, B., Schroeder, R.E. Journal of applied toxicology : JAT. (2005) [Pubmed]
  3. Conversion of methionine to methional by Lactococcus lactis. Amárita, F., Fernández-Esplá, D., Requena, T., Pelaez, C. FEMS Microbiol. Lett. (2001) [Pubmed]
  4. Chemical evidence for production of hydroxyl radicals during microsomal electron transfer. Cohen, G., Cederbaum, A.I. Science (1979) [Pubmed]
  5. Evidence for hydroxyl radical production by human neutrophils. Tauber, A.I., Babior, B.M. J. Clin. Invest. (1977) [Pubmed]
  6. Human DNA damage induced by 1,2,4-benzenetriol, a benzene metabolite. Kawanishi, S., Inoue, S., Kawanishi, M. Cancer Res. (1989) [Pubmed]
  7. Mechanism for irreversible self-deactivation of prostaglandin synthetase. Egan, R.W., Paxton, J., Kuehl, F.A. J. Biol. Chem. (1976) [Pubmed]
  8. Metabolism of carcinogenic urethane to nitric oxide is involved in oxidative DNA damage. Sakano, K., Oikawa, S., Hiraku, Y., Kawanishi, S. Free Radic. Biol. Med. (2002) [Pubmed]
  9. Evaluation of the role of methional, 2-keto-4-methylthiobutyric acid and peroxidase in ethylene formation by Escherichia coli. Primrose, S.B. J. Gen. Microbiol. (1977) [Pubmed]
  10. Methional derived from 4-methylthio-2-oxobutanoate is a cellular mediator of apoptosis in BAF3 lymphoid cells. Quash, G., Roch, A.M., Chantepie, J., Michal, Y., Fournet, G., Dumontet, C. Biochem. J. (1995) [Pubmed]
  11. Altered methional homoeostasis is associated with decreased apoptosis in BAF3 bcl2 murine lymphoid cells. Roch, A.M., Quash, G., Michal, Y., Chantepie, J., Chantegrel, B., Deshayes, C., Doutheau, A., Marvel, J. Biochem. J. (1996) [Pubmed]
  12. Methional, a cellular metabolite, induces apoptosis preferentially in G2/M-synchronized BAF3 murine lymphoid cells. Roch, A.M., Panaye, G., Michal, Y., Quash, G. Cytometry. (1998) [Pubmed]
  13. Methionine oxidation and apoptosis induction by ascorbate, gallate and hydrogen peroxide. Sakagami, H., Satoh, K., Kadofuku, T., Takeda, M. Anticancer Res. (1997) [Pubmed]
  14. Production of hydroxyl radical by human alveolar macrophages. Hoidal, J.R., Beall, G.D., Repine, J.E. Infect. Immun. (1979) [Pubmed]
  15. Effect of low and high methional concentrations on prostaglandin biosynthesis in microsomes from bovine and sheep vesicular glands. Panganamala, R.V., Gavino, V.C., Cornwell, D.G. Prostaglandins (1979) [Pubmed]
  16. Role of hydroxyl radical scavengers dimethyl sulfoxide, alcohols and methional in the inhibition of prostaglandin biosynthesis. Panganamala, R.V., Sharma, H.M., Heikkila, R.E., Geer, J.C., Cornwell, D.G. Prostaglandins (1976) [Pubmed]
  17. A phase I trial of recombinant human gamma interferon (IFN-gamma 4A) in patients with advanced malignancy. Perez, R., Lipton, A., Harvey, H.A., Simmonds, M.A., Romano, P.J., Imboden, S.L., Giudice, G., Downing, M.R., Alton, N.K. Journal of biological response modifiers. (1988) [Pubmed]
  18. N-acetylcysteine, a cancer chemopreventive agent, causes oxidative damage to cellular and isolated DNA. Oikawa, S., Yamada, K., Yamashita, N., Tada-Oikawa, S., Kawanishi, S. Carcinogenesis (1999) [Pubmed]
  19. Site-specific DNA damage induced by nickel(II) ion in the presence of hydrogen peroxide. Kawanishi, S., Inoue, S., Yamamoto, K. Carcinogenesis (1989) [Pubmed]
  20. The mechanism of guanine specific photooxidation in the presence of berberine and palmatine: Activation of photosensitized singlet oxygen generation through DNA-binding interaction. Hirakawa, K., Kawanishi, S., Hirano, T. Chem. Res. Toxicol. (2005) [Pubmed]
  21. Hydroxyl radical formation in phagocytic cells of the rat. Drath, D.B., Karnovsky, M.L., Huber, G.L. Journal of applied physiology: respiratory, environmental and exercise physiology. (1979) [Pubmed]
  22. Mechanism of oxidative DNA damage induced by quercetin in the presence of Cu(II). Yamashita, N., Tanemura, H., Kawanishi, S. Mutat. Res. (1999) [Pubmed]
  23. Enhancement of the primary flavor compound methional in potato by increasing the level of soluble methionine. Di, R., Kim, J., Martin, M.N., Leustek, T., Jhoo, J., Ho, C.T., Tumer, N.E. J. Agric. Food Chem. (2003) [Pubmed]
  24. Reactions of oxygen radical species with methional: a pulse radiolysis study. Bors, W., Lengfelder, E., Saran, M., Fuchs, C., Michel, C. Biochem. Biophys. Res. Commun. (1976) [Pubmed]
  25. Model studies on the efficacy of protein homogenates from raw pork muscle and dry-cured ham in binding selected flavor compounds. Pérez-Juan, M., Flores, M., Toldrá, F. J. Agric. Food Chem. (2006) [Pubmed]
 
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