The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Pyridiminol     1H-pyrimidin-2-one

Synonyms: Pyrimidinol, PYRIMIDINEONE, pyrimidin-2-ol, SureCN1460, PubChem20310, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of NSC56052

  • The more active analogues (ED50), including 4-pyri-dylpyrimidines 4a (38), 4b (47), and 4g (49) and 2-hydroxypyrimidine 8r (43), were then tested against adjuvant-induced edema in the rat [1].

High impact information on NSC56052


Biological context of NSC56052


Anatomical context of NSC56052

  • The cytosol by itself exhibited some nitroreductase activities, which were markedly enhanced by addition of an electron donor of aldehyde oxidase, i.e., N1-methylnicotinamide or 2-hydroxypyrimidine [2].
  • The metabolism of diazinon, an organo-phosphorothionate pesticide, to diazoxon and pyrimidinol has been studied in incubations with hepatic microsomes from control Sprague-Dawley (SD) rats or SD rats treated with different P450-specific inducers (phenobarbital, dexamethasone, beta-napthoflavone, and pyrazole) [8].

Associations of NSC56052 with other chemical compounds


Analytical, diagnostic and therapeutic context of NSC56052

  • Serum activity was assessed in as close to physiological conditions as possible (at pH 7.4, 150 mM NaCl and 37 degrees C with 50 microM diazoxon as substrate) and by quantifying pyrimidinol formation using high-performance liquid chromatography [13].


  1. Synthesis and antiinflammatory activity of trisubstituted pyrimidines and triazines. Bennett, G.B., Mason, R.B., Alden, L.J., Roach, J.B. J. Med. Chem. (1978) [Pubmed]
  2. Reductive metabolism of aromatic nitro compounds including carcinogens by rabbit liver preparations. Tatsumi, K., Kitamura, S., Narai, N. Cancer Res. (1986) [Pubmed]
  3. Stimulation of natural killer cells in two random-bred strains of athymic rats by interferon-inducing pyrimidinone. Lotzová, E., Savary, C.A., Khan, A., Stringfellow, D.A. J. Immunol. (1984) [Pubmed]
  4. Nicotinamide N-oxide reductase activity in bovine and rabbit eyes. Shimada, S., Mishima, H., Kitamura, S., Tatsumi, K. Invest. Ophthalmol. Vis. Sci. (1987) [Pubmed]
  5. Identification of aldehyde oxidase as the neonicotinoid nitroreductase. Dick, R.A., Kanne, D.B., Casida, J.E. Chem. Res. Toxicol. (2005) [Pubmed]
  6. Antiandrogenic activity and metabolism of the organophosphorus pesticide fenthion and related compounds. Kitamura, S., Suzuki, T., Ohta, S., Fujimoto, N. Environ. Health Perspect. (2003) [Pubmed]
  7. Metabolic activation of zebularine, a novel DNA methylation inhibitor, in human bladder carcinoma cells Ben-Kasus T, Ben-Zvi Z, Marquez VE, Kelley JA, Agbaria R, Department of Clinical Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel. Hsieh, J.T. Urol. Oncol. (2006) [Pubmed]
  8. Identification of the cytochrome P450 isoenzymes involved in the metabolism of diazinon in the rat liver. Fabrizi, L., Gemma, S., Testai, E., Vittozzi, L. J. Biochem. Mol. Toxicol. (1999) [Pubmed]
  9. Guinea pig liver aldehyde oxidase as a sulfoxide reductase: its purification and characterization. Yoshihara, S., Tatsumi, K. Arch. Biochem. Biophys. (1985) [Pubmed]
  10. Involvement of molybdenum hydroxylases in reductive metabolism of nitro polycyclic aromatic hydrocarbons in mammalian skin. Ueda, O., Sugihara, K., Ohta, S., Kitamura, S. Drug Metab. Dispos. (2005) [Pubmed]
  11. Involvement of mammalian liver cytosols and aldehyde oxidase in reductive metabolism of zonisamide. Sugihara, K., Kitamura, S., Tatsumi, K. Drug Metab. Dispos. (1996) [Pubmed]
  12. Metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in perfused rat liver: involvement of hepatic aldehyde oxidase as a detoxification enzyme. Yoshihara, S., Harada, K., Ohta, S. Drug Metab. Dispos. (2000) [Pubmed]
  13. Genetic and other sources of variation in the activity of serum paraoxonase/diazoxonase in humans: consequences for risk from exposure to diazinon. O'Leary, K.A., Edwards, R.J., Town, M.M., Boobis, A.R. Pharmacogenet. Genomics (2005) [Pubmed]
WikiGenes - Universities