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Gene Review

AOX1  -  aldehyde oxidase 1

Bos taurus

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Disease relevance of AOX1

  • Lesions of suspected bovine tuberculosis were examined by culture, histopathology and auramine-O (AO) stained smears and the findings correlated with field aspects of the disease [1].

High impact information on AOX1


Biological context of AOX1


Anatomical context of AOX1


Associations of AOX1 with chemical compounds


Regulatory relationships of AOX1

  • A cDNA encoding the extracellular domain of bovine TNF-RI was placed under the control of the powerful and tightly regulated alcohol oxidase1 (AOX1) gene promoter of the pPICZa A vector and the resulting construct integrated into the 5' region of the alcohol oxidase genes of GS115 and KM71 strains of Pichia [10].

Other interactions of AOX1

  • A Pichia pastoris expression system for bovine pancreatic RNase A was constructed: the RNase A sequence was fused to the PHO1 signal and the AOX1 promoter was used for efficient secretion [11].

Analytical, diagnostic and therapeutic context of AOX1


  1. Laboratory diagnosis of bovine tuberculosis. Claxton, P.D., Eamens, G.J., Mylrea, P.J. Aust. Vet. J. (1979) [Pubmed]
  2. Convergent neofunctionalization by positive Darwinian selection after ancient recurrent duplications of the xanthine dehydrogenase gene. Rodríguez-Trelles, F., Tarrío, R., Ayala, F.J. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  3. Purification, cDNA cloning, and tissue distribution of bovine liver aldehyde oxidase. Calzi, M.L., Raviolo, C., Ghibaudi, E., de Gioia, L., Salmona, M., Cazzaniga, G., Kurosaki, M., Terao, M., Garattini, E. J. Biol. Chem. (1995) [Pubmed]
  4. Activity staining of plasma amine oxidase after polyacrylamide gel electrophoresis and its application to natural inhibitor screening. Lee, M.H., Chuang, M.T., Hou, W.C. Electrophoresis (2002) [Pubmed]
  5. Expression of eukaryotic glycosyltransferases in the yeast Pichia pastoris. Bencúrová, M., Rendić, D., Fabini, G., Kopecky, E.M., Altmann, F., Wilson, I.B. Biochimie (2003) [Pubmed]
  6. Contribution of aldehyde oxidase, xanthine oxidase, and aldehyde dehydrogenase on the oxidation of aromatic aldehydes. Panoutsopoulos, G.I., Kouretas, D., Beedham, C. Chem. Res. Toxicol. (2004) [Pubmed]
  7. Molecular cloning and characterization of aldehyde oxidases in Arabidopsis thaliana. Sekimoto, H., Seo, M., Kawakami, N., Komano, T., Desloire, S., Liotenberg, S., Marion-Poll, A., Caboche, M., Kamiya, Y., Koshiba, T. Plant Cell Physiol. (1998) [Pubmed]
  8. Nicotinamide N-oxide reductase activity in bovine and rabbit eyes. Shimada, S., Mishima, H., Kitamura, S., Tatsumi, K. Invest. Ophthalmol. Vis. Sci. (1987) [Pubmed]
  9. Purification of aldehyde oxidase from bovine ciliary body. Shimada, S., Mishima, H.K., Nikaido, H., Kitamura, S., Tatsumi, K. Curr. Eye Res. (1989) [Pubmed]
  10. Expression and characterization of a recombinant soluble form of bovine tumor necrosis factor receptor type I. Mwangi, S.M., Stabel, J., Lee, E., Kehrli, M.E., Taylor, M.J. Vet. Immunol. Immunopathol. (2000) [Pubmed]
  11. Expression of soluble bovine pancreatic ribonuclease A in Pichia pastoris and its purification and characterization. Chatani, E., Tanimizu, N., Ueno, H., Hayashi, R. Biosci. Biotechnol. Biochem. (2000) [Pubmed]
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