Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

TALAMPICILLIN (3-oxo-1H-isobenzofuran-1-yl) (2R,5R,6S)-6...

Synonyms: TAPC, Talampicilina, Talampicilline, SureCN34338, CHEBI:9391, ...

Akimoto, Y. et al., Jeffery, D.J. et al., Price, J.D. et al., Ensink, J.M. et al., Saeed, A. et al., et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of TALAMPICILLIN

Letter: Infectious-mononucleosis rash after talampicillin [1].
Ampicillin concentrations in human dental granuloma after a single oral administration of talampicillin [2].
A total of 241 out of 245 (98%) cases had the urethral gonococcus successfully eradicated with talampicillin [3].
Four hundred and sixty women with uncomplicated gonorrhea were treated with a single oral dose of 1.5 g talampicillin [4].
Evaluation & comparison of single dose oral treatment of uncomplicated gonococcal urethritis in males with talampicillin & minocycline [5].

High impact information on TALAMPICILLIN

The bioavailability for four different commerically available brands of ampicillin compared with that of talampicillin [6].
In the in vitro study, 90% decomposition of the ester took place in 30, 60, and 5 minutes, for pivampicillin, bacampicillin, and talampicillin, respectively [7].
Talampicillin in the treatment and prophylaxis of urinary tract infection in children [8].
5. Studies in vitro showed that the intestinal wall is an important site of hydrolysis of talampicillin in rat and dog [9].
4. Unchanged talampicillin was present in the hepatic portal vein blood of dog and thus reached the liver, whereas in rat, no parent compound could be detected in portal vein blood [9].

Biological context of TALAMPICILLIN

Kinetics of talampicillin decomposition in solutions [10].

Anatomical context of TALAMPICILLIN

The mean peak concentrations in serum (9.64 micrograms/ml), gingiva (4.72 micrograms/mg), mandibular bone (1.77 micrograms/ml), dental follicle (3.46 micrograms/ml), and dental pulp (5.53 micrograms/mg) all occurred at approximately 150 minutes after administration of talampicillin [11].
Eighty-one patients who underwent the extraction of impacted mandibular third molars in the nonfasting state were given a single oral dose of talampicillin (500 mg) preoperatively [11].

Analytical, diagnostic and therapeutic context of TALAMPICILLIN

Talampicillin was effective in eradicating the causitive organism in uncomplicated gonorrhoea, with only four treatment failures (1-6%) in 245 patients seen at least once after treatment [3].

References

Letter: Infectious-mononucleosis rash after talampicillin. Morris, J. Lancet (1976) [Pubmed]
Ampicillin concentrations in human dental granuloma after a single oral administration of talampicillin. Akimoto, Y., Nishimura, H., Komiya, M., Kaneko, K., Fujii, A., Tamura, T. Antimicrob. Agents Chemother. (1988) [Pubmed]
Oral talampicillin in the treatment of gonorrhoea. Price, J.D., Fluker, J.L., Giles, J.H. The British journal of venereal diseases. (1977) [Pubmed]
Treatment of uncomplicated gonorrhoea in women with talampicillin in a single oral 1.5 g dose. Mohanty, K.C., Roy, R.B. The British journal of venereal diseases. (1982) [Pubmed]
Evaluation & comparison of single dose oral treatment of uncomplicated gonococcal urethritis in males with talampicillin & minocycline. Saeed, A., Roy, R.B. The British journal of clinical practice. (1979) [Pubmed]
The bioavailability for four different commerically available brands of ampicillin compared with that of talampicillin. Hamilton-Miller, J.M., Brumfitt, W. J. Antimicrob. Chemother. (1979) [Pubmed]
Oral bioavailability and in vitro stability of pivampicillin, bacampicillin, talampicillin, and ampicillin in horses. Ensink, J.M., Vulto, A.G., van Miert, A.S., Tukker, J.J., Winkel, M.B., Fluitman, M.A. Am. J. Vet. Res. (1996) [Pubmed]
Talampicillin in the treatment and prophylaxis of urinary tract infection in children. Smellie, J.M., Grüneberg, R.N., Bantock, H.M., Katz, G. Chemotherapy. (1982) [Pubmed]
The metabolism of talampicillin in rat, dog and man. Jeffery, D.J., Jones, K.H., Langley, P.F. Xenobiotica (1978) [Pubmed]
Kinetics of talampicillin decomposition in solutions. Pawełczyk, E., Płotkowiak, Z., Helska, M. Acta poloniae pharmaceutica. (2002) [Pubmed]
Ampicillin concentrations in human serum, gingiva, mandibular bone, dental follicle, and dental pulp following a single oral dose of talampicillin. Akimoto, Y., Kaneko, K., Fujii, A., Tamura, T. J. Oral Maxillofac. Surg. (1985) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.