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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Dental Pulp

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Disease relevance of Dental Pulp


Psychiatry related information on Dental Pulp


High impact information on Dental Pulp

  • We measured the dental pulp profile area (PRATIO [= pulp area/tooth area]) and serum phosphorus (Pi) values in uniformly treated XLH patients (six males, 81 teeth, 1,457 Pi values; 11 females, 129 teeth, 1,439 Pi values) [7].
  • The collagen bundles were more often observed in the 12-day gland cultured in the presence of bovine dental pulp collagenase inhibitor, which had been shown to enhance cleft formation [8].
  • An interstitial collagenase was purified from the explant medium of bovine dental pulp and was shown to degrade collagens I and III but not IV and V [8].
  • Clinical relevance of these observations came from immunohistochemical analysis showing that CCL2 was expressed in vivo by odontoblasts and blood vessels present under active carious lesions but not in healthy dental pulps [9].
  • HPCs expressed both mRNA and the products of calcitonin gene-related peptide, substance P, and proteinase-activated receptor-2 (PAR-2) that were also found in dental pulp fibroblast-like cells [10].

Chemical compound and disease context of Dental Pulp


Biological context of Dental Pulp


Anatomical context of Dental Pulp


Associations of Dental Pulp with chemical compounds


Gene context of Dental Pulp


Analytical, diagnostic and therapeutic context of Dental Pulp


  1. Insertional inactivation of pac and rmlB genes reduces the release of tumor necrosis factor alpha, interleukin-6, and interleukin-8 induced by Streptococcus mutans in monocytic, dental pulp, and periodontal ligament cells. Engels-Deutsch, M., Pini, A., Yamashita, Y., Shibata, Y., Haikel, Y., Schöller-Guinard, M., Klein, J.P. Infect. Immun. (2003) [Pubmed]
  2. Effects of TGFbeta1 on dental pulp cells in cultured human tooth slices. Melin, M., Joffre-Romeas, A., Farges, J.C., Couble, M.L., Magloire, H., Bleicher, F. J. Dent. Res. (2000) [Pubmed]
  3. Substance P activates p38 mitogen-activated protein kinase to promote IL-6 induction in human dental pulp fibroblasts. Tokuda, M., Miyamoto, R., Sakuta, T., Nagaoka, S., Torii, M. Connect. Tissue Res. (2005) [Pubmed]
  4. Ability of healthy and inflamed human dental pulp to reduce hydrogen peroxide. Esposito, P., Varvara, G., Murmura, G., Terlizzi, A., Caputi, S. Eur. J. Oral Sci. (2003) [Pubmed]
  5. A simple in vito cytotoxicity test using the MTT (3-(4,5)-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) colorimetric assay: analysis of eugenol toxicity on dental pulp cells (RPC-C2A). Kasugai, S., Hasegawa, N., Ogura, H. Jpn. J. Pharmacol. (1990) [Pubmed]
  6. Experimental pain thresholds and plasma beta-endorphin levels during exercise. Droste, C., Greenlee, M.W., Schreck, M., Roskamm, H. Medicine and science in sports and exercise. (1991) [Pubmed]
  7. X-linked hypophosphatemia: the mutant gene is expressed in teeth as well as in kidney. Shields, E.D., Scriver, C.R., Reade, T., Fujiwara, T.M., Morgan, K., Ciampi, A., Schwartz, S. Am. J. Hum. Genet. (1990) [Pubmed]
  8. The role of interstitial collagens in cleft formation of mouse embryonic submandibular gland during initial branching. Fukuda, Y., Masuda, Y., Kishi, J., Hashimoto, Y., Hayakawa, T., Nogawa, H., Nakanishi, Y. Development (1988) [Pubmed]
  9. Lipoteichoic acid increases TLR and functional chemokine expression while reducing dentin formation in in vitro differentiated human odontoblasts. Durand, S.H., Flacher, V., Roméas, A., Carrouel, F., Colomb, E., Vincent, C., Magloire, H., Couble, M.L., Bleicher, F., Staquet, M.J., Lebecque, S., Farges, J.C. J. Immunol. (2006) [Pubmed]
  10. Neuropeptide release from dental pulp cells by RgpB via proteinase-activated receptor-2 signaling. Tancharoen, S., Sarker, K.P., Imamura, T., Biswas, K.K., Matsushita, K., Tatsuyama, S., Travis, J., Potempa, J., Torii, M., Maruyama, I. J. Immunol. (2005) [Pubmed]
  11. Tissue levels of immunoreactive substance P are increased in patients with irreversible pulpitis. Bowles, W.R., Withrow, J.C., Lepinski, A.M., Hargreaves, K.M. Journal of endodontics. (2003) [Pubmed]
  12. The effects of capsaicin on pulpal blood flow. Liu, M., Pertl, C., Markowitz, K., Dörscher-Kim, J., Kim, S. Proceedings of the Finnish Dental Society. Suomen Hammaslääkäriseuran toimituksia. (1992) [Pubmed]
  13. The effect of collagen and indomethacin on inflamed dental pulp wounds of baboon teeth. Oguntebi, B.R., Dover, M.S., Franklin, C.J., Tuwaijri, A.S. Oral Surg. Oral Med. Oral Pathol. (1988) [Pubmed]
  14. Vascular changes in the dental pulp in the hypercholesterolemic miniature swine. Oguntebi, B.R., Stafford, D.S., Cerda, J., Robbins, F. Oral Surg. Oral Med. Oral Pathol. (1992) [Pubmed]
  15. Regulatory role of transforming growth factor-beta, bone morphogenetic protein-2, and protein-4 on gene expression of extracellular matrix proteins and differentiation of dental pulp cells. Nakashima, M., Nagasawa, H., Yamada, Y., Reddi, A.H. Dev. Biol. (1994) [Pubmed]
  16. The role of vascular endothelial growth factor in human dental pulp cells: induction of chemotaxis, proliferation, and differentiation and activation of the AP-1-dependent signaling pathway. Matsushita, K., Motani, R., Sakuta, T., Yamaguchi, N., Koga, T., Matsuo, K., Nagaoka, S., Abeyama, K., Maruyama, I., Torii, M. J. Dent. Res. (2000) [Pubmed]
  17. Prostaglandin E2 enhances bradykinin-evoked iCGRP release in bovine dental pulp. Goodis, H.E., Bowles, W.R., Hargreaves, K.M. J. Dent. Res. (2000) [Pubmed]
  18. TGF-beta1 induces accumulation of dendritic cells in the odontoblast layer. Farges, J.C., Romeas, A., Melin, M., Pin, J.J., Lebecque, S., Lucchini, M., Bleicher, F., Magloire, H. J. Dent. Res. (2003) [Pubmed]
  19. Differential effects of nitric oxide synthesis inhibition on basal blood flow and antidromic vasodilation in rat oral tissues. Kerezoudis, N.P., Olgart, L., Edwall, L. Eur. J. Pharmacol. (1993) [Pubmed]
  20. Stimulation of reparative dentin formation by ex vivo gene therapy using dental pulp stem cells electrotransfected with growth/differentiation factor 11 (Gdf11). Nakashima, M., Iohara, K., Ishikawa, M., Ito, M., Tomokiyo, A., Tanaka, T., Akamine, A. Hum. Gene Ther. (2004) [Pubmed]
  21. Induction of dental pulp stem cell differentiation into odontoblasts by electroporation-mediated gene delivery of growth/differentiation factor 11 (Gdf11). Nakashima, M., Mizunuma, K., Murakami, T., Akamine, A. Gene Ther. (2002) [Pubmed]
  22. Production of colony-stimulating factor in human dental pulp fibroblasts. Sawa, Y., Horie, Y., Yamaoka, Y., Ebata, N., Kim, T., Yoshida, S. J. Dent. Res. (2003) [Pubmed]
  23. Cloning human enamelin cDNA, chromosomal localization, and analysis of expression during tooth development. Hu, C.C., Hart, T.C., Dupont, B.R., Chen, J.J., Sun, X., Qian, Q., Zhang, C.H., Jiang, H., Mattern, V.L., Wright, J.T., Simmer, J.P. J. Dent. Res. (2000) [Pubmed]
  24. Immunohistochemical evidence for the occurrence of endothelin in the vascular endothelium of normal and inflamed human dental pulp. Casasco, A., Casasco, M., Ciuffreda, M., Springall, D.R., Calligaro, A., Bianchi, S., Polak, J.M. J. Dent. Res. (1992) [Pubmed]
  25. Altered vascular permeability in the dental pulp of traumatised rat teeth. Araujo, V.C., Araujo, N.S., Mariano, M. J. Pathol. (1980) [Pubmed]
  26. Histological considerations of direct pulp capping agents. Heys, D.R., Cox, C.F., Heys, R.J., Avery, J.K. J. Dent. Res. (1981) [Pubmed]
  27. Properties of kininase in rat dental pulp. Maita, E., Endo, Y., Ogura, Y. J. Dent. Res. (1984) [Pubmed]
  28. Endogenous biosynthesis of prostaglandin I2 and thromboxane A2 by isolated rat dental pulp. Hirafuji, M., Ogura, Y. Biochem. Pharmacol. (1983) [Pubmed]
  29. Glial cell line-derived neurotrophic factor (GDNF) from adult rat tooth serves a distinct population of large-sized trigeminal neurons. Kvinnsland, I.H., Luukko, K., Fristad, I., Kettunen, P., Jackson, D.L., Fjeld, K., von Bartheld, C.S., Byers, M.R. Eur. J. Neurosci. (2004) [Pubmed]
  30. Nitric oxide synthase in healthy and inflamed human dental pulp. Di Nardo Di Maio, F., Lohinai, Z., D'Arcangelo, C., De Fazio, P.E., Speranza, L., De Lutiis, M.A., Patruno, A., Grilli, A., Felaco, M. J. Dent. Res. (2004) [Pubmed]
  31. Expression of growth/differentiation factor 11, a new member of the BMP/TGFbeta superfamily during mouse embryogenesis. Nakashima, M., Toyono, T., Akamine, A., Joyner, A. Mech. Dev. (1999) [Pubmed]
  32. In vivo and in vitro effects of zinc oxide-eugenol (ZOE) on biosynthesis of cyclo-oxygenase products in rat dental pulp. Hashimoto, S., Uchiyama, K., Maeda, M., Ishitsuka, K., Furumoto, K., Nakamura, Y. J. Dent. Res. (1988) [Pubmed]
  33. Brain sites involved in the antinociceptive effect of bradykinin in rats. Couto, L.B., Corrêa, F.M., Pelá, I.R. Br. J. Pharmacol. (1998) [Pubmed]
  34. Neurokinin A-like immunoreactivity in feline dental pulp: its distribution, origin and coexistence with substance P-like immunoreactivity. Wakisaka, S., Ichikawa, H., Nishikawa, S., Matsuo, S., Takano, Y., Akai, M. Cell Tissue Res. (1988) [Pubmed]
  35. Cat dental pulp after denervation and subsequent re-innervation: changes in blood-flow regulation and distribution of neuropeptide-, GAP-43- and low-affinity neurotrophin receptor-like immunoreactivity. Olgart, L., Edwall, L., Fried, K. Brain Res. (1993) [Pubmed]
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