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Chemical Compound Review

AC1NSJTW     1-ethoxycarbonyloxyethyl (2R,5R,6S)-6...

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Disease relevance of bacampicillin


High impact information on bacampicillin


Chemical compound and disease context of bacampicillin


Biological context of bacampicillin


Anatomical context of bacampicillin

  • The peripheral mononuclear blastogenic index (ratio between PHA-induced and spontaneous proliferation), PHA-induced interferon-gamma production, percentages of T and B lymphocytes, serum immunoglobulins (IgG, IgM, IgA) levels, failed to show any significative differences before and after the treatment with bacampicillin [5].
  • Patients with acute urinary tract infections given 400 mg bacampicillin and patients with chronic infections given double that dosage showed equally good results [18].
  • Mean peak serum levels of nearly 12 mg/l were found after 1600 mg bacampicillin (mean peak level in sputum 0.85 mg/l) [19].
  • Bacampicillin in a dose of 1200 mg was administered orally before the operation and the concentrations in serum, sinus mucosa and secretion were assayed [20].
  • Study on tissue concentrations of antibiotics: bacampicillin in gingiva and maxillary bones [21].

Associations of bacampicillin with other chemical compounds


Gene context of bacampicillin

  • Four patients with rhinitis and two patients with ACD were available for studying the immunophenotype and the TCR-Vbeta repertoire of bacampicillin induced lymphoblasts as well as the cytokine profiles and expression of the activation markers CD23 and CD134 in primary PBMC cultures [8].
  • The detection limit, i.e. 1 microM, for bacampicillin was comparable to what could be achieved with CE/MS on a quadrupole instrument using selected ion monitoring and sheath flow ESI [25].
  • For bacampicillin, mean peak concentrations of 7.6 and 14.4 micrograms/ml were found in the sera of fasting patients after administration of 27.8 mg of drug/ml in Veegum and microcapsular suspensions, respectively [26].

Analytical, diagnostic and therapeutic context of bacampicillin


  1. Antibacterial activity and pharmacokinetics of bacampicillin and ampicillin. Rozencweig, M., Staquet, M., Klastersky, J. Clin. Pharmacol. Ther. (1976) [Pubmed]
  2. The lymphocyte transformation test for diagnosis of drug-induced occupational allergy. Stejskal, V.D., Olin, R.G., Forsbeck, M. J. Allergy Clin. Immunol. (1986) [Pubmed]
  3. Comparison of three different doses of bacampicillin given twice daily to patients with acute exacerbations of chronic bronchitis in a clinical dose-response study. Maesen, F.P., Davies, B.I., Sjövall, J. J. Antimicrob. Chemother. (1981) [Pubmed]
  4. Bacampicillin twice daily in acute maxillary sinusitis: an alternative dosage regimen. von Sydow, C., Einarsson, S., Grafford, K., Hansson, P., Jensen, C. J. Antimicrob. Chemother. (1981) [Pubmed]
  5. Bacampicillin and the immune response. Scordamaglia, A., Ciprandi, G., Mirabelli, S., Aquilina, R., Calcagno, L., Nicolini, A., Simonassi, C., De Palma, M. J. Antimicrob. Chemother. (1987) [Pubmed]
  6. Dose-dependent absorption of amoxycillin and bacampicillin. Sjövall, J., Alván, G., Westerlund, D. Clin. Pharmacol. Ther. (1985) [Pubmed]
  7. Therapy of acute otitis media caused by Branhamella catarrhalis. Preliminary report. Shurin, P.A., Van Hare, G.F. Drugs (1986) [Pubmed]
  8. Characterization of primary recall in vitro lymphocyte responses to bacampicillin in allergic subjects. Cederbrant, K., Marcusson-Stâhl, M., Hultman, P. Clin. Exp. Allergy (2000) [Pubmed]
  9. Distribution of ampicillin to chronic maxillary inflammatory tissues (granuloma) after administration of a single dose of bacampicillin. Heimdahl, A., Movin, G., Englund, G., Nord, C.E. J. Antimicrob. Chemother. (1988) [Pubmed]
  10. Effect on urogenital flora of antibiotic therapy for urinary tract infection. Reid, G., Bruce, A.W., Cook, R.L., Llano, M. Scand. J. Infect. Dis. (1990) [Pubmed]
  11. Local and systemic immune response in Helicobacter pylori-associated chronic gastritis before and after treatment. Engstrand, L., Gustavsson, S., Schwan, A., Scheynius, A. Scand. J. Gastroenterol. (1993) [Pubmed]
  12. Comparison between bacampicillin and amoxycillin in treating genital and extragenital infection with Neisseria gonorrhoeae and pharyngeal infection with Neisseria meningitidis. Edwards, L.D., Gartner, T. The British journal of venereal diseases. (1984) [Pubmed]
  13. Sultamicillin experiences in the field of internal medicine. Hara, K., Kobayashi, H. APMIS Suppl. (1989) [Pubmed]
  14. Influence of food and reduced gastric acidity on the bioavailability of bacampicillin and cefuroxime axetil. Sommers, D.K., van Wyk, M., Moncrieff, J., Schoeman, H.S. British journal of clinical pharmacology. (1984) [Pubmed]
  15. Potential improvement in the shelf life of parenterals using the prodrug approach: bacampicillin and talampicillin hydrolysis kinetics and utilization time. Nguyen, N.A., Mortada, L.M., Notari, R.E. Pharm. Res. (1988) [Pubmed]
  16. Effect of bacampicillin and ampicillin on the phagocytic, microbicidal functions of human macrophages. Cuffini, A.M., Carlone, N.A., Tullio, V. Journal of chemotherapy (Florence, Italy) (1991) [Pubmed]
  17. Two cases of acquired syphilis with acute central chorioretinitis as initial manifestation. Yagasaki, T., Akiyama, K., Nomura, H., Awaya, S. Jpn. J. Ophthalmol. (1992) [Pubmed]
  18. Elimination of bacteria during antibacterial chemotherapy--a neglected parameter of chemotherapy. Helm, E.B., Munk, I., Shah, P.M., Stille, W. Infection (1979) [Pubmed]
  19. Serum and sputum antibiotic levels after ampicillin, amoxycillin and bacampicillin chronic bronchitis patients. Davies, B., Maesen, F. Infection (1979) [Pubmed]
  20. A pharmacokinetic study of bacampicillin in patients with chronic maxillary sinusitis. Sorri, M., Jokinen, K., Peltomäki, E. Infection (1979) [Pubmed]
  21. Study on tissue concentrations of antibiotics: bacampicillin in gingiva and maxillary bones. del Piano, M., Nicosia, R., Sessa, R., Grippaudo, G., Lolli, R., Monaco, B. Chemotherapy. (1988) [Pubmed]
  22. Correlation between the bioavailability of microencapsulated bacampicillin hydrochloride in suspension and in vitro microcapsule dissolution. Sjövall, J., Sjöqvist, R., Huitfeldt, B., Nyqvist, H. Journal of pharmaceutical sciences. (1984) [Pubmed]
  23. No effect of omeprazole-induced hypoacidity on the bioavailability of amoxycillin or bacampicillin. Paulsen, O., Höglund, P., Walder, M. Scand. J. Infect. Dis. (1989) [Pubmed]
  24. Pharmacokinetics of bacampicillin in equids. Sarasola, P., McKellar, Q.A. Am. J. Vet. Res. (1995) [Pubmed]
  25. Optimization of capillary electrophoresis conditions for coupling to a mass spectrometer via a sheathless interface. Samskog, J., Wetterhall, M., Jacobsson, S., Markides, K. Journal of mass spectrometry : JMS. (2000) [Pubmed]
  26. Comparative pharmacokinetics of bacampicillin and ampicillin suspensions in infants and children. Ginsburg, C.M., McCracken, G.H., Clahsen, J., Zweighaft, T. Rev. Infect. Dis. (1981) [Pubmed]
  27. Intrarenal concentration-time profile of ampicillin after administration of bacampicillin to patients before nephrectomy. Seppänen, J., Hällström, O., Sjövall, J., Vaalasti, T. Journal of clinical pharmacology. (1986) [Pubmed]
  28. Ampicillin concentration in normal and pathological lung tissues after oral administration of bacampicillin. Hällström, O., Keyriläinen, O., Markkula, H. Infection (1979) [Pubmed]
  29. Bacampicillin in acute maxillary sinusitis: concentration in sinus secretion and clinical effect. A randomized, double-blind study of two dosage regimens. Sorri, M., Peltomäki, E., Jokinen, K. Scand. J. Infect. Dis. (1981) [Pubmed]
  30. A micromethod for determination of antimicrobial agents in bone. Heimdahl, A., Cars, O., Hedberg, M., Movin, G., Nord, C.E. Drugs under experimental and clinical research. (1988) [Pubmed]
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