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Disease relevance of Gonorrhea


High impact information on Gonorrhea


Chemical compound and disease context of Gonorrhea


Biological context of Gonorrhea


Anatomical context of Gonorrhea


Gene context of Gonorrhea

  • Based on different prime-boost protocols, we could polarize immune responses to predominantly Th1 or Th2, which should enable future studies of the types of immune responses that are protective in mouse models of gonorrhea [20].
  • A history of chlamydial infection (26.0%) and gonorrhea (13.0%) were more common in the SFM women than in either the COMP (16.0% and 3.0%) or the SSM (19.0% and 4.0%) groups [21].
  • Of the 31 remaining strains of other auxotypes isolated from patients with uncomplicated gonorrhea, 18 (58.1%) were sensitive to normal human sera in titers ranging from 2 to 2,048 [22].
  • Por1B gonococci bound chimpanzee C4bp and resisted killing by chimpanzee serum, providing insight into the host restriction of gonorrhea and addressing why Por1B strains, but not Por1A strains, have been successful in experimental chimpanzee infection [23].
  • Although both the AHU auxotype and protein IA serogroup were found to be associated with disseminated gonococcal infection, there was no direct correlation of IgA1 protease type with disseminated or with uncomplicated gonorrhea [24].

Analytical, diagnostic and therapeutic context of Gonorrhea



  1. A comparison of single-dose cefixime with ceftriaxone as treatment for uncomplicated gonorrhea. The Gonorrhea Treatment Study Group. Handsfield, H.H., McCormack, W.M., Hook, E.W., Douglas, J.M., Covino, J.M., Verdon, M.S., Reichart, C.A., Ehret, J.M. N. Engl. J. Med. (1991) [Pubmed]
  2. Serologic diagnosis of Lymphogranuloma venereum by counterimmunoelectrophoresis with a Chlamydia trachomatis protein antigen. Caldwell, H.D., Kuo, C.C. J. Immunol. (1977) [Pubmed]
  3. Dose ranging study of cefpimizole (U-63196E) for treatment of uncomplicated gonorrhea in men. Sandberg, E.T., Pegram, P.S., Roddy, R.E., Handsfield, H.H., Hampton, K.D., Shafran, K.M., Hook, E.W. Antimicrob. Agents Chemother. (1986) [Pubmed]
  4. The link between the use of crack cocaine and the sexually transmitted diseases of a clinic population. A comparison of adolescents with adults. Ellen, J.M., Langer, L.M., Zimmerman, R.S., Cabral, R.J., Fichtner, R. Sexually transmitted diseases. (1996) [Pubmed]
  5. Epidemiologic differences between chlamydia and gonorrhea. Zimmerman, H.L., Potterat, J.J., Dukes, R.L., Muth, J.B., Zimmerman, H.P., Fogle, J.S., Pratts, C.I. American journal of public health. (1990) [Pubmed]
  6. Effect of treatment regimens for Neisseria gonorrhoeae on simultaneous infection with Chlamydia trachomatis. Stamm, W.E., Guinan, M.E., Johnson, C., Starcher, T., Holmes, K.K., McCormack, W.M. N. Engl. J. Med. (1984) [Pubmed]
  7. Cefoxitin as a single-dose treatment for urethritis caused by penicillinase-producing Neisseria gonorrhoeae. Berg, S.W., Kilpatrick, M.E., Harrison, W.O., McCutchan, J.A. N. Engl. J. Med. (1979) [Pubmed]
  8. A trial of minocycline given after exposure to prevent gonorrhea. Harrison, W.O., Hooper, R.R., Wiesner, P.J., Campbell, A.F., Karney, W.W., Reynolds, G.H., Jones, O.G., Holmes, K.K. N. Engl. J. Med. (1979) [Pubmed]
  9. Spectinomycin versus tetracycline for the treatment of gonorrhea. Karney, W.W., Pedersen, A.H., Nelson, M., Adams, H., Pfeifer, R.T., Holmes, K.K. N. Engl. J. Med. (1977) [Pubmed]
  10. Ampicillin therapy for pharyngeal gonorrhea. Di Caprio, J.M., Reynolds, J., Frank, G., Carbone, J., Nishimura, R. JAMA (1978) [Pubmed]
  11. Therapy of gonorrhea. Comparison of trimethoprim-sulfamethoxazole and ampicillin. Sattler, F.R., Ruskin, J. JAMA (1978) [Pubmed]
  12. Effect of nonoxynol-9 gel on urogenital gonorrhea and chlamydial infection: a randomized controlled trial. Roddy, R.E., Zekeng, L., Ryan, K.A., Tamoufé, U., Tweedy, K.G. JAMA (2002) [Pubmed]
  13. Antigenic variation during infection with Neisseria gonorrhoeae: detection of antibodies to surface proteins in sera of patients with gonorrhea. Zak, K., Diaz, J.L., Jackson, D., Heckels, J.E. J. Infect. Dis. (1984) [Pubmed]
  14. Treatment of uncomplicated gonococcal infection with trimethoprim-sulfamethoxazole. Brown, S.T., Thompson, S.E., Biddle, J.W., Kraus, S.J., Zaidi, A.A., Kleris, G.S. Sexually transmitted diseases. (1982) [Pubmed]
  15. Ceftriaxone for treatment of uncomplicated gonorrhea: routine use of a single 125-mg dose in a sexually transmitted disease clinic. Handsfield, H.H., Hook, E.W. Sexually transmitted diseases. (1987) [Pubmed]
  16. Persistence of two genotypes of Neisseria gonorrhoeae during transmission. Martin, I.M., Ghani, A., Bell, G., Kinghorn, G., Ison, C.A. J. Clin. Microbiol. (2003) [Pubmed]
  17. Clinical and bacteriologic efficacy of ceftriaxone in the United States. McCloskey, R.V. Am. J. Med. (1984) [Pubmed]
  18. Urinary leukocyte esterase screening for asymptomatic sexually transmitted disease in adolescent males. Werner, M.J., Biro, F.M. The Journal of adolescent health : official publication of the Society for Adolescent Medicine. (1991) [Pubmed]
  19. Enoxacin: a new fluoroquinolone. Jaber, L.A., Bailey, E.M., Rybak, M.J. Clinical pharmacy. (1989) [Pubmed]
  20. DNA immunization of mice with a plasmid encoding Neisseria gonorrhea PorB protein by intramuscular injection and epidermal particle bombardment. Zhu, W., Thomas, C.E., Sparling, P.F. Vaccine (2004) [Pubmed]
  21. Sexually transmitted diseases in Swedish women with experience of casual sex with men of foreign nationalities within Sweden. Arvidson, M., Hellberg, D., Mårdh, P.A. Acta obstetricia et gynecologica Scandinavica. (1995) [Pubmed]
  22. Gonococci causing disseminated gonococcal infection are resistant to the bactericidal action of normal human sera. Schoolnik, G.K., Buchanan, T.M., Holmes, K.K. J. Clin. Invest. (1976) [Pubmed]
  23. Human C4b-binding protein selectively interacts with Neisseria gonorrhoeae and results in species-specific infection. Ngampasutadol, J., Ram, S., Blom, A.M., Jarva, H., Jerse, A.E., Lien, E., Goguen, J., Gulati, S., Rice, P.A. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  24. Immunoglobulin A1 protease types of Neisseria gonorrhoeae and their relationship to auxotype and serovar. Mulks, M.H., Knapp, J.S. Infect. Immun. (1987) [Pubmed]
  25. Comparative double-blind study of 200- and 400-mg enoxacin given orally in the treatment of acute uncomplicated urethral gonorrhea in males. van der Willigen, A.H., van der Hoek, J.C., Wagenvoort, J.H., van Vliet, H.J., van Klingeren, B., Schalla, W.O., Knapp, J.S., van Joost, T., Michel, M.F., Stolz, E. Antimicrob. Agents Chemother. (1987) [Pubmed]
  26. Assembly and antigenicity of the Neisseria gonorrhoeae pilus mapped with antibodies. Forest, K.T., Bernstein, S.L., Getzoff, E.D., So, M., Tribbick, G., Geysen, H.M., Deal, C.D., Tainer, J.A. Infect. Immun. (1996) [Pubmed]
  27. Enzyme immunoassay for diagnosis of gonorrhea. Schachter, J., McCormack, W.M., Smith, R.F., Parks, R.M., Bailey, R., Ohlin, A.C. J. Clin. Microbiol. (1984) [Pubmed]
  28. Treatment failure with the use of ciprofloxacin for gonorrhea correlates with the prevalence of fluoroquinolone-resistant Neisseria gonorrhoeae strains in Bangladesh. Rahman, M., Alam, A., Nessa, K., Nahar, S., Dutta, D.K., Yasmin, L., Monira, S., Sultan, Z., Khan, S.A., Albert, M.J. Clin. Infect. Dis. (2001) [Pubmed]
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